GLUCAGON: Its Role in Physiology and Clinical Medicine : Its Role in Physiology and Clinical Medice

The growing interest in glucagon. almost universal among diabetologists. made the decision to hold a satellite symposium immediately after the IX Congress of the International Diabetes Federation easy. indeed almost unavoidable. The climate. the beauty of its uniquely picturesque canals and houseboats. of its lakes and its mountains and above all. the friendliness of its people made the choice of Sri nagar equally easy. Problems of transportation and housing which appeared of Himalayan proportions from thousands of miles away were resolved with deceptive ease: as if the late autumn sun of New Delhi and Sri nagar had melted the snow that already covered many areas of the United States. For this. we thank the Executive Council and the Scientific Program Advisory Committee of the Congress. the Chairman and Co-Chairman of the local committee, Drs. Ali Mohammed Jan and S. N. Ahmed Shah; the Organizing Secretary, Dr. Syed Zahoor Ahmed; the joint Secretary, Dr. M. Y. Alvi; the Secretary of the Scientific Session. S. N. Dhar and the other committee members, Drs. G. Q. Allaqband, Wm. Riberio, Girja Dhar, J. A. Naqashbandi and Messrs. D. P. Zutshi, K. Amla and Ajit Singh. We are deeply grateful to His Excellency Sheikh Abdullah, Chief Minister of Jammu and Kashmir for his interest in the symposium and for the unforgettable hospitality offered in the name of his people. The suggestions, criticism and understanding of many colleagues helped us select topics and speakers for a representative rather than a comprehensive program. Content: Front Matter....Pages i-xli Front Matter....Pages n1-n1 Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production....Pages 1-22 Morphologic Study of Glucagon Release....Pages 23-30 Front Matter....Pages n2-n2 Glucagon Biosynthesis in Anglerfish Islets: Identification of A 4,900 Dalton Metabolic Conversion Intermediate....Pages 31-50 High Molecular Weight Glucagons from Avian Islets and Fetal Bovine Pancreas....Pages 51-63 Assessment of Glucagon Immunoreactivity in Plasma....Pages 65-76 Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States....Pages 77-92 Circulating Glucagon Components: Significance in Health and Disease....Pages 93-112 Plasma Immunoreactive Glucagon in Depancreatized Animals....Pages 113-127 Heterogeneity of Gut Glucagon-Like Immunoreactivity (GLI)....Pages 129-135 Glucagon-Like Materials in Porcine and Rat Intestinal Mucosa....Pages 137-141 Immunoreactive Glucagon in the Salivary Glands of Man and Animal....Pages 143-155 Role of the Submaxillary Gland and of the Kidney in the Hyperglucagonemia of Eviscerated Rats....Pages 157-166 Glucagon and the Kidney....Pages 167-176 Front Matter....Pages n3-n3 The Role of Calcium in Glucagon Secretion....Pages 177-183 The Versatile Role of Calcium in Glucagon Release....Pages 185-213 Interrelationship of Calcium and Somatostatin in the Secretion of Insulin and Glucagon....Pages 215-230 Dynamics and Interrelationships of In Vitro Secretion of Glucagon and Insulin....Pages 231-241 Effects of Insulin on the Glucagon Release, Glucose Utilization and ATP Content of the Pancreatic A Cells of the Guinea Pig....Pages 243-254 Effect of Vasoactive Intestinal Peptide (VIP) and Gastric Inhibitory Peptide (GIP) on Insulin and Glucagon Release by Perifused Newborn Rat Pancreas....Pages 255-269 The Role of the Autonomic Nervous System in Glucagon Secretion....Pages 271-286 Front Matter....Pages n4-n4 Interactions of Hepatocyte Membrane Receptors with Pancreatic and Gut Glucagon....Pages 287-303 Glucagon, Insulin and their Hepatic Receptors: An Endocrine Pattern Characterizing Hepatoproliferative Transitions in the Rat....Pages 305-319 Reexamination of the Second Messenger Hypothesis of Glucagon and Catecholamine Action in Liver....Pages 321-347 Guanyl Nucleotide Regulation of the Liver Glucagon-Sensitive Adenylyl Cyclase System....Pages 349-371 A Peptide Inhibitor of Glucagon-Responsive Adenylate Cyclase in Liver....Pages 373-378 Modulation of Nuclear Protein Kinase Activity by Glucagon....Pages 379-391 Combined Influence of Insulin and Glucagon Upon Hepatocytes in Rats with Liver Loss or Viral Injury....Pages 393-402 Front Matter....Pages n5-n5 Insulin and Glucagon (Pancreatic and Extrapancreatic) Interactions and the Regulation of Glucose Turnover in Physiology and in the Diabetic State....Pages 403-436 Regulation of Hepatic Gluconeogenesis by Glucagon in the Rat....Pages 437-458 Hormonal Regulation of Hepatic Protein Metabolism in the Rat In Vivo. Control by Glucagon....Pages 459-485 The Role of Glucagon in Amino Acid Homeotasis....Pages 487-494 The Roles of Glucagon and Cyclic Adenosine 3′,5′-Monophosphate in the Regulation of Lipid Biosynthesis....Pages 495-516 Lowering of Plasma Lipids, The Major Effect of Repeated Glucagon Administration in Rats....Pages 517-532 Glucagon and Lipoprotein Regulation in Man....Pages 533-550 Metabolic Fuels in the Embryo and the Newborn....Pages 551-561 Role of the Insulin/Glucagon Ratio in the Changes of Hepatic Metabolism During Development of the Rat....Pages 563-581 Glucose Homeostasis in the Newborn....Pages 583-593 Front Matter....Pages n6-n6 New Concepts in Glucagon Physiology....Pages 595-605 The Issues Related to Abnormal A Cell Function in Diabetes Mellitus....Pages 607-615 On the Causes and Consequences of Abnormal Glucagon Secretion in Human Diabetes Mellitus....Pages 617-641 Front Matter....Pages n6-n6 The Effects of Exogenously Induced Hyperglucagonemia in Insulin-Treated Diabetics....Pages 643-650 The Nature of the A Cell Abnormality in Human Diabetes Mellitus....Pages 651-661 The Nature of Hyperglucagonemia in Diabetes Mellitus....Pages 663-677 Glucagon in Diabetic Coma....Pages 679-689 Glucagon Metabolism in Potential Diabetes Mellitus. Studies of Discordant Twins and Patients After Myocardial Infarction....Pages 691-698 Tolbutamide: Stimulator and Suppressor of Glucagon Secretion....Pages 699-710 Effect of Long Term Sulfonylurea Therapy on Glucagon Levels in Maturity Onset Diabetes Mellitus....Pages 711-721 Effect of Chlorpropamide on Basal and Arginine-Stimulated Plasma Levels of Glucagon and Insulin in Diabetic Patients....Pages 723-733 Glucagon and Hypertriglyceridemia....Pages 735-757 Glucagonomas and Skin Disease....Pages 759-763 Plasma GLI in Gastrectomized Patients....Pages 765-776 Pancreatic A Cell Function in a Patient with Addison’s Disease....Pages 777-781 Back Matter....Pages 783-793 I. Ontogeny of the A Cell and the Morphology of Glucagon Release.- Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production.- Morphologic Study of Glucagon Release.- II. Biosynthesis, Nature and Sites of Origin of Pancreatic Glucagon and of Glucagon-Like Immunoreactive Materials.- Glucagon Biosynthesis in Anglerfish Islets: Identification of a 4,900 Dalton Metabolic Conversion Intermediate.- High Molecular Weight Glucagons from Avian Islets and Fetal Bovine Pancreas.- Assessment of Glucagon Immunoreactivity in Plasma.- Quantification of Plasma Glucagon Immunoreactive Components in