Glioma Signaling (Advances in Experimental Medicine and Biology Book 986)

Glioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nucleotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration changes, cellular growth, progression and invasion, as well as presents perspective concerning potential targets for glioma therapy. Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy Front Matter....Pages i-x Introduction to Purinergic Signalling in the Brain....Pages 1-12 Adenosine Signaling in Glioma Cells....Pages 13-30 Cross-Talk in Nucleotide Signaling in Glioma C6 Cells....Pages 31-59 Calcium Signaling in Glioma Cells – The Role of Nucleotide Receptors....Pages 61-79 Purinergic Signaling in Glioma Progression....Pages 81-102 Cytoskeleton and Nucleotide Signaling in Glioma C6 Cells....Pages 103-119 Signaling Determinants of Glioma Cell Invasion....Pages 121-141 Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion....Pages 143-170 TGF Beta Signaling and Its Role in Glioma Pathogenesis....Pages 171-187 STAT Signaling in Glioma Cells....Pages 189-208 Cannabinoid Signaling in Glioma Cells....Pages 209-220 Back Matter....Pages 221-227