Glioblastoma: : Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies

Glioblastoma, the deadliest of all primary brain tumors, is heterogenic and has very complex pathology and multiple mechanisms of cell proliferation and growth. This book describes all the latest concepts about the molecular mechanisms of pathogenesis of glioblastoma and new therapeutic opportunities. The contributors to this book include basic scientists and clinicians, who are experts in the field, and dedicated investigators in finding novel strategies for treatment of glioblastoma. It is important for us to know the strategies we have accumulated so far for the management of this malignancy so that we can make further attempts to explore unknown avenues to combat it completely in the near future. Front Matter....Pages i-xi Overview of the Molecular Genetics and Molecular Chemotherapy of GBM....Pages 1-42 Primary Brain Tumors: Characteristics, Practical Diagnostic and Treatment Approaches....Pages 43-75 Pathology of Glioblastoma Multiforme....Pages 77-84 Molecular Mechanisms of Pathogenesis in Glioblastoma and Current Therapeutic Strategies....Pages 85-93 Aberrant Signalling Complexes in GBMs: Prognostic and Therapeutic Implications....Pages 95-129 Role of Aberrant Cell Cycle in the Growth and Pathogenesis of Glioblastoma....Pages 131-151 Adult Neural Stem Cells and Gliomagenesis....Pages 153-165 Divide and Invade: The Dynamic Cytoskeleton of Glioblastoma Cells....Pages 167-183 Aberrations of the Epigenome in Gliomas: Novel Targets for Therapy....Pages 185-202 Chemotherapy for Glioblastoma: Past, Present, and Future....Pages 203-216 Role of Angiogenesis in the Pathogenesis of Glioblastoma and Antiangiogenic Therapies for Controlling Glioblastoma....Pages 217-241 Antiangiogenic Strategies for the Treatment of Gliomas....Pages 243-263 Retinoids for the Treatment of Glioblastoma....Pages 265-281 Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas....Pages 283-298 Current Endeavors for Enhancing Efficacy of Paclitaxel for Treatment of Glioblastoma....Pages 299-323 Dietary Polyphenols as Preventive and Therapeutic Agents in Glioblastoma....Pages 325-339 Targeting Energy Metabolism in Brain Cancer with Restricted Diets....Pages 341-363 Immunotherapy for Glioblastoma....Pages 365-397 Potential of Nanobiotechnology in the Management of Glioblastoma Multiforme....Pages 399-419 Back Matter....Pages 421-431 Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field. Glioblastoma is the most malignant brain tumor that remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. This book offers information on glioblastoma. It is suitable for students, postdoctoral fellows, principal investigators, and clinicians involved in this field Glioblastoma is the most malignant brain tumor that still remains incurable. This book discusses the histopathology and molecular biology of glioblastoma as well as current treatment strategies, many of them groundbreaking.