Genomics of Pattern Recognition Receptors : Applications in Oncology and Cardiovascular Diseases

This Book Offers Comprehensive Information On The Polymorphisms Of Genes Encoding Pattern Recognition Receptors (prrs). Following A Short Description Of The General Role Of Prrs In The Immune System, The Structure And Function Of Toll-like And Nod-like Receptors Are Examined In Detail. The Main Focus Is On The Role Of Inherited Variation In Prrs And Their Correlation To Cancer And Cardiovascular Diseases. A Review Of All Epidemiological Investigations Is Included, And A Concept Of Genomic Risk Markers For The Prevention Of Various Diseases Is Also Discussed.-- The Biology Of Toll-like Receptors And Nod-like Receptors: Toggles Of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, And Cancer: A Double-edged Sword -- Structural Genomic Variation In Toll-like Receptor 4 And Cancer -- Structural Genomic Variation In Other Toll-like Receptors And Cancer -- Structural Genomic Variation In Toll-like Receptor Signaling Pathway And Cancer -- Structural Genomic Variation In Toll-like Receptor Pathway And Prostate Cancer -- Structural Genomic Variation In Nod-like Receptors And Cancer -- Structural Genomic Variation In Pattern Recognition Receptors And Cardiovascular Diseases -- Hot Spots In The Field: Where Should We Go. Anton G. Kutikhin, Arsenij E. Yuzhalinches Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Front Matter....Pages i-xi The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation....Pages 1-25 Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword....Pages 27-32 Structural Genomic Variation in TLR4 Gene and Cancer....Pages 33-55 Structural Genomic Variation in Other Toll-Like Receptors and Cancer....Pages 57-76 Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer....Pages 77-100 Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer....Pages 101-121 Structural Genomic Variation in NOD-Like Receptors and Cancer....Pages 123-151 Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases....Pages 153-167 Hot Spots in the Field: Where Should We Go?....Pages 169-176 Back Matter....Pages 177-185 This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.-- Source other than Library of Congress