Genomic and Personalized Medicine, Two-Vol Set: Genomic and Personalized Medicine Volume 2, Volume 2: Genome Discoveries and Clinical Applications

This two-volume set — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine.Volume One Includes:Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care.Volume Two Includes:Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. Highly Commended 2013 BMA Medical Book Award for Medicine Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine. Content: Copyright Page , Page ii Acknowledgements , Page xxix Advisory Board , Page xxxix Foreword , Pages xxv-xxvi Preface , Pages xxvii-xxviii Contributors , Pages xli-xlvii Chapter 1 - Organization, Variation and Expression of the Human Genome as a Foundation of Genomic and Personalized Medicine , Pages 1,3,4-21 , Huntington F. Willard Chapter 2 - Concepts of Population Genomics , Pages 22-32 , Mike E. Weale, David B. Goldstein Chapter 3 - Genomic Approaches to Complex Disease , Pages 33-46 , Desmond J. Smith, Aldons J. Lusis Chapter 4 - Human Health and Disease: Interaction Between the Genome and the Environment , Pages 47-59 , Kenneth Olden Chapter 5 - Epigenomics and Its Implications for Medicine , Pages 60-73 , Moshe Szyf Chapter 6 - Systems Biology and the Emergence of Systems Medicine , Pages 74-85 , Nathan D. Price, Lucas B. Edelman, Inyoul Lee, Hyuntae Yoo, Daehee Hwang, George Carlson, David J. Galas, James R. Heath, Leroy Hood Chapter 7 - DNA Sequencing for the Detection of Human Genome Variation and Polymorphism , Pages 87,88-100 , Samuel Levy, Yu-Hui Rogers Chapter 8 - Genome-Wide Association Studies and Genotyping Technologies , Pages 101-107 , Kevin V. Shianna Chapter 9 - Copy Number Variation and Human Health , Pages 108-119 , Charles Lee, Courtney Hyland, Arthur S. Lee, Shona Hislop, Chunhwa Ihm Chapter 10 - Inter-Species Comparative Sequence Analysis: A Tool for Genomic Medicine , Pages 120-130 , Anthony Antonellis, Eric D. Green Chapter 11 - DNA Methylation Analysis: Providing New Insight into Human Disease , Pages 131-142 , Susan Cottrell, Theo deVos, Juergen Distler, Carolina Haefliger, Ralf Lesche, Achim Plum, Matthias Schuster Chapter 12 - Transcriptomics: Translation of Global Expression Analysis to Genomic Medicine , Pages 143-156 , Michelle M. Kittleson, Rafael Irizarry, Bettina Heidecker, Joshua M. Hare Chapter 13 - DNA Microarrays in Biological Discovery and Patient Care , Pages 157-172 , Andrew J. Yee, Sridhar Ramaswamy Chapter 14 - Proteomics: The Deciphering of the Functional Genome , Pages 173-179 , Li-Rong Yu, Nicolas A. Stewart, Timothy D. Veenstra Chapter 15 - Comprehensive Metabolic Analysis for Understanding of Disease Mechanisms , Pages 180-192 , Christopher B. Newgard, Robert D. Stevens, Brett R. Wenner, Shawn C. Burgess, Olga Ilkayeva, Michael J. Muehlbauer, A. Dean Sherry, James R. Bain Chapter 16 - Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics , Pages 193-203 , Bjorn T. Gjertsen, James B. Lorens Chapter 17 - Bioinformatic and Computational Analysis for Genomic Medicine , Pages 205,206-225 , Atul J. Butte Chapter 18 - Fundamentals and History of Informatics for Genomic and Personalized Medicine , Pages 226-232 , A. Jamie Cuticchia Chapter 19 - Electronic Medical Records in Genomic Medicine Practice and Research , Pages 233-241 , Glenn S. Gerhard, Robert D. Langer, David J. Carey, Walter F. Stewart Chapter 20 - Clinical Decision Support in Genomic and Personalized Medicine , Pages 242-251 , Kensaku Kawamoto, David F. Lobach Chapter 21 - Online Health Information Retrieval by Consumers and the Challenge of Personal Genomics , Pages 252-257 , Mark S. Boguski Chapter 22 - Translational Genomics: From Discovery to Clinical Practice , Pages 259,261,262-274 , Geoffrey S. Ginsburg Chapter 23 - Principles of Study Design , Pages 275-283 , Peter Grass Chapter 24 - Biobanking in the Post-Genome Era , Pages 284-298 , Theresa Puifun Chow, Chia Kee Seng, Per Hall, Edison T. Liu Chapter 25 - Application of Biomarkers in Human Population Studies , Pages 299-307 , Stefano Bonassi, Monica Neri Chapter 26 - Validation of Candidate Protein Biomarkers , Pages 308-320 , Ingibjörg Hilmarsdóttir, Nader Rifai Chapter 27 - Pharmacogenetics and Pharmacogenomics , Pages 321-334 , Iris Grossman, David B. Goldstein Chapter 28 - The Role of Genomics and Genetics in Drug Discovery and Development , Pages 335-342 , Robert I. Tepper, Ronenn Roubenoff Chapter 29 - Role of Pharmacogenomics in Drug Development , Pages 343-356 , Colin F. Spraggs, Beena T. Koshy, Mark R. Edbrooke, Allen D. Roses Chapter 30 - Clinical Implementation of Translational Genomics , Pages 357-366 , Wendy K. Chung Chapter 31 - Translating Innovation in Diagnostics: Challenges and Opportunities , Pages 367-377 , Matthew P. Brown, Myla Lai-Goldman, Paul R. Billings Chapter 32 - The Role of Genomics in Enabling Prospective Health Care , Pages 378-385 , Ralph Snyderman Chapter 33 - From Sequence to Genomic Medicine: Genome Policy Considerations , Pages 387,388-400 , Susanne B. Haga Chapter 34 - Educational Strategies in Genomic Medicine , Pages 401-413 , Charles J. Epstein Chapter 35 - Federal Regulation of Genomic Medicine , Pages 414-423 , Janet Woodcock Chapter 36 - Economic Issues and Genomic Medicine , Pages 424-433 , David L. Veenstra,, Louis P. Garrison,, Scott D. Ramsey Chapter 37 - Public–Private Interactions in Genomic Medicine: Research and Development , Pages 434-444 , Subhashini Chandrasekharan,, Noah C. Perin,, Ilse R. Wiechers,, Robert Cook-Deegan Chapter 38 - What Is Public Health Genomics? , Pages 445,446-453 , Alison Stewart, Ron Zimmern Chapter 39 - Why Do We Need Public Health in the Era of Genomic Medicine? , Pages 454-460 , Muin J. Khoury, Marta Gwinn Chapter 40 - Principles of Human Genome Epidemiology , Pages 461-469 , Marta Gwinn, Muin J. Khoury Chapter 41 - Genomics and Population Screening: Example of Newborn Screening , Pages 470-480 , John D. Thompson, Michael Glass Chapter 42 - Family History: A Bridge Between Genomic Medicine and Disease Prevention , Pages 481-492 , Maren T. Scheuner, Paula W. Yoon Chapter 43 - Molecular Imaging as a Paradigm for Genomic and Personalized Medicine , Pages 493,494-499 , Ralph Weissleder Chapter 44 - PET Imaging in Genomic Medicine , Pages 500-511 , Vikas Kundra, Osama Mawlawi Chapter 45 - MRI for Molecular ImagingApplications: Overview, Perspectives, and Challenges , Pages 512-523 , Dmitri Artemov Chapter 46 - Fluorescence Imaging: Overview and Applications in Biomedical Research , Pages 524-531 , Vasilis Ntziachristos Chapter 47 - Imaging Genetics: Integration of Neuroimaging and Genetics in the Search for Predictive Markers , Pages 532-537 , Ahmad R. Hariri Chapter 48 - Viral Chip Technology in Genomic Medicine , Pages 538-561 , Zeno Földes-Papp Vaccines Against Infectious Diseases: A Biotechnology-Driven Evolution , Pages 562-572 , Vega Masignani, Hervé Tettelin, Rino Rappuoli Chapter 50 - Cancer Vaccines: Some Basic Considerations , Pages 573-589 , Hans-Georg Rammensee, Harpreet Singh-Jasuja, Niels Emmerich, Steve Pascolo Chapter 51 - Biosensors for the Genomic Age , Pages 590-598 , Meghan B. O'Donoghue, Lin Wang, Yan Chen, Gang Yao, Weihong Tan Chapter 52 - Stem Cells , Pages 599-609 , Rikkert L. Snoeckx, Kris Van Den Bogaert, Catherine M. Verfaillie Chapter 53 - Gene Therapy , Pages 610-619 , James M. Wilson, Nelson A. Wivel Chapter 54 - The Genomics of Hypertension , Pages 621,623,624-633 , Chana Yagil, Yoram Yagil Chapter 55 - Lipoprotein Disorders , Pages 634-651 , Sekar Kathiresan, Daniel J. Rader Chapter 56 - Reactive oxygen species signals leading to vascular dysfunction and atherosclerosis , Pages 652-664 , Nageswara R. Madamanchi, Aleksandr E. Vendrov, Marschall S. Runge Chapter 57 - Genomics of Myocardial Infarction , Pages 665-679 , Carlos A. Hubbard, Eric J. Topol Chapter 58 - Acute Coronary Syndromes , Pages 680-691 , L. Kristin Newby Chapter 59 - Heart Failure in the Era of Genomic Medicine , Pages 692-704 , Ivor J. Benjamin, Jeetendra Patel Chapter 60 - Application of Genomic Methodology for Assessment of Cardiac Transplant Rejection , Pages 705-715 , Michael Pham, Mario C. Deng, Jay Wohlgemuth, Thomas Quertermous Chapter 61 - Hypertrophic Cardiomyopathy in the Era of Genomic Medicine , Pages 716-728 , J. Martijn Bos, Steve R. Ommen, Michael J. Ackerman Chapter 62 - Genetics and Genomics of Arrhythmias , Pages 729-754 , Jeffrey A. Towbin, Matteo Vatta Chapter 63 - Hemostasis and Thrombosis , Pages 755-772 , Richard C. Becker,, Felicita Andreotti Chapter 64 - Genetic Polymorphisms in Peripheral Arterial Disease, Role of Genomic Methodologies , Pages 773-780 , Ayotunde O. Dokun, Brian H. Annex Chapter 65 - Genomics of Congenital Heart Disease , Pages 781-793 , Jessie H. Conta, Roger E. Breitbart Chapter 66 - Genomics of Perioperative and Procedural Medicine , Pages 794-805 , Simon C. Body, Mihai V. Podgoreanu, Debra A. Schwinn Chapter 67 - Cancer Genes, Genomes, and the Environment , Pages 807,808-817 , Robert L. Strausberg Chapter 68 - Immune Cells and the Tumor Microenvironment , Pages 818-829 , David S. Hsu, Michael Morse, Timothy Clay, Gayathri Devi, H. Kim Lyerly Chapter 69 - Lymphomas , Pages 830-843 , Lisa Rimsza Chapter 70 - Genomics in Leukemias , Pages 844-855 , Lars Bullinger, Hartmut Dohner, Jonathan R. Pollack Chapter 71 - Genomics of Lung Cancer , Pages 856-868 , Hasmeena Kathuria, Avrum Spira, Jerome Brody Chapter 72 - Breast Cancer and Genomic Medicine , Pages 869-878 , Erich S. Huang, Andrew T. Huang Chapter 73 - Colorectal Cancer , Pages 879-897 , G.L. Wiesner, T.P. Slavin, J.S. Barnholtz-Sloan Chapter 74 - Prostate Cancer , Pages 898-912 , Phillip G. Febbo, Philip W. Kantoff Chapter 75 - Molecular Biology of Ovarian Cancer , Pages 913-920 , Tanja Pejovic, Matthew L. Anderson, Kunle Odunsi Chapter 76 - Pancreatic Neoplasms , Pages 921-930 , Asif Khalid, Kevin McGrath Chapter 77 - The Multiple Endocrine Neoplasia Syndromes , Pages 931-944 , Y. Nancy You, Vipul Lakhani, Samuel A. Wells Chapter 78 - Genomics of Head and Neck Cancer , Pages 945-955 , Giovana R. Thomas, Yelizaveta Shnayder Chapter 79 - Genomic Medicine, Brain Tumors and Gliomas , Pages 956-966 , Sean E. Lawler, E. Antonio Chiocca Chapter 80 - Molecular Therapeutics of Melanoma , Pages 967-976 , Jiaqi Shi, Yonmei Feng, Robert S. Krouse,, Stanely Leong, Mark A. Nelson Chapter 81 - Emerging Concepts in Metastasis , Pages 977-989 , Nigel P.S. Crawford, Kent W. Hunter Chapter 82 - Diagnostic-Therapeutic Combinations in the Treatment of Cancer , Pages 990-1007 , Jeffrey S. Ross Chapter 83 - Environmental Exposures and the Emerging Field of Environmental Genomics , Pages 1009,1010-1016 , David A. Schwartz Chapter 84 - Molecular Basis of Rheumatoid Arthritis , Pages 1017-1031 , Robert M. Plenge, Michael E. Weinblatt Chapter 85 - “Omics” in the Study of Multiple Sclerosis , Pages 1032-1039 , Francisco J. Quintana, Howard L. Weiner Chapter 86 - Inflammatory Bowel Disease , Pages 1040-1055 , Ad A. van Bodegraven and Cisca Wijmenga Chapter 87 - Glomerular Disorders , Pages 1056-1066 , Tadashi Yamamoto, Hidehiko Fujinaka, Visith Thongboonkerd Chapter 88 - Spondyloarthropathies , Pages 1067-1083 , Dirk Elewaut, Filip De Keyser, Filip Van den Bosch, Dieter Deforce, Herman Mielants Chapter 89 - Asthma Genomics , Pages 1084-1097 , Scott T. Weiss, Benjamin A. Raby, Juan C. Celedón Chapter 90 - Genomic Aspects of Chronic Obstructive Pulmonary Disease , Pages 1098-1109 , Peter J Barnes Chapter 91 - Genomic Determinants of Interstitial Lung Disease , Pages 1110-1121 , Paul W. Noble and Mark P. Steele Chapter 92 - Peptic Ulcer Disease , Pages 1122-1137 , John Holton Chapter 93 - Cirrhosis in the Era of Genomic Medicine , Pages 1138-1154 , N.A. Shackel, K. Patel, J. McHutchison Chapter 94 - Systemic Sclerosis , Pages 1155-1168 , Ulf Müller-Ladner Chapter 95 - Genomic Medicine and Obesity , Pages 1169,1170-1186 , J. Alfredo Martínez Chapter 96 - Diabetes , Pages 1187-1193 , Maggie Ng, Nancy J. Cox Chapter 97 - Metabolic Syndrome , Pages 1194-1203 , Rebecca L. Pollex, Robert A. Hegele Chapter 98 - N utrition and Diet in the Era of G enomics , Pages 1204-1220 , Jose M. Ordovas, Dolores Corella Chapter 99 - The Genetic Approach to Dementia , Pages 1221,1222-1232 , Robert L. Nussbaum Chapter 100 - Parkinson’s Disease: Genomic Perspectives , Pages 1233-1242 , Shushant Jain, Andrew B. Singleton Chapter 101 - Epilepsy Predisposition and Pharmacogenetics , Pages 1243-1255 , Nicole M. Walley, David B. Goldstein Chapter 102 - Ophthalmology , Pages 1256-1264 , Janey L. Wiggs Chapter 103 - The Genomic Basis of Neuromuscular Disorders , Pages 1265-1281 , Erynn S. Gordon, Eric P. Hoffman Chapter 104 - Psychiatric Disorders , Pages 1282-1288 , Stephan Züchner, Ranga Krishnan Chapter 105 - Genomics and Depression , Pages 1289-1298 , Brigitta Bondy Chapter 106 - Bipolar Disorder in the Era of Genomic Psychiatry , Pages 1299-1311 , Ayman H. Fanous, Frank Middleton, Carlos N. Pato, Michele T. Pato Chapter 107 - Genomic Approaches to the Host Response to Pathogens , Pages 1313,1314-1323 , M. Frances Shannon Chapter 108 - Genomic Medicine and AIDS , Pages 1324-1339 , Thomas Hirtzig, Yves Lévy, Jean-François Zagury Chapter 109 - Viral Genomics and Antiviral Drugs , Pages 1340-1346 , Roberto Patarca Chapter 110 - Host Genomics and Bacterial Infections , Pages 1347-1361 , Melissa D. Johnson, Mihai Netea Chapter 111 - Sepsis and the Genomic Revolution , Pages 1362-1374 , Christopher W. Woods, Robert J. Feezor, Stephen F. Kingsmore Chapter 112 - Diagnosis, Management and Disease Mechanisms of Hepatitis in the Era of Genomic Medicine , Pages 1375-1389 , N.A. Shackel, K. Patel, J. McHutchison Glossary , Pages 1391-1406 Index , Pages 1407-1478 This two-volume set provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine.


Volume One Includes:

Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care.


Volume Two Includes:

Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine.



* Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine.
* Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine.
* Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine. This two-volume set provides an indepth look at one of the most promising avenues for advances in preventing and treating human genetic diseases. This handbook presents basic principles of human disease genetics and epidemiology/statistics, with a thorough understanding of applications and methods of genome technologies. With full color throughout, this reference provides a detailed assessment of the current developments in genomic medicine for each of the major disease groups. With the latest information on diagnostic testing, population screening, predicting disease susceptibility and more, this handbook is an essential tool for specialists and graduate students across medical disciplines including: human genetics/genomics, oncology, neuroscience, gene therapy, molecular medicine, and biomedical sciences. Provides information on genomic applications and impact on medicine to the major disease groups: Cancer, Cardiovascular, Infectious Disease, Neurological, Renal, Psychiatr