Genetics of Colorectal Cancer (Cancer Genetics Book 14)

The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, __MYH__-Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. __Genetics of Colorectal Cancer__ provides the most up-to-date information in each of these areas. Front Matter....Pages i-xi Colorectal Cancer: Epidemiology....Pages 5-25 Mouse Models of Intestinal Cancer....Pages 27-49 The Chromosomal-Instability Pathway and APC Gene Mutation in Colorectal Cancer....Pages 53-72 DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis....Pages 73-95 Pathways and Pathology....Pages 97-121 Familial Adenomatous Polyposis....Pages 125-139 DNA Mismatch Repair and Lynch Syndrome....Pages 141-169 Additional Syndromes with Hereditary Predisposition to Colorectal Cancer....Pages 173-181 Familial Colorectal Cancer Type X....Pages 183-186 Families with Serrated Neoplasia of the Colon....Pages 187-191 Peutz–Jeghers Syndrome....Pages 193-198 Juvenile Polyposis....Pages 199-205 BLM Mutation and Colorectal Cancer Susceptibility....Pages 207-212 The Role of p53 in Colorectal Cancer....Pages 213-217 Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer....Pages 219-220 Genetic Variability in Folate-Mediated One-Carbon Metabolism and Risk of Colorectal Neoplasia....Pages 223-242 Genetic Variability in NSAID Targets and NSAID-Metabolizing Enzymes and Colorectal Neoplasia....Pages 243-260 The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer....Pages 261-276 Calcium and Vitamin D....Pages 277-298 Back Matter....Pages 299-309 The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, MYH -Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. Genetics of Colorectal Cancer provides the most up-to-date information in each of these areas. Genetic susceptibility refers to how variations in a person's genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology. Genetic susceptibility refers to how variations in a person 's genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology Genetic susceptibility refers to how variations in a person's genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This book explores various findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology