Genetic response to metals : proceedings of the First International Symposium "Metals and Genetics", held May 24-27, 1994, in Toronto, Ontario, Canada, under the auspices of the Hospital for Sik Children, Toronto, Canada ... [et al

Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity \* examines metal compounds that cleave DNA, their design, and mechanisms of action \* explores future applications for targeting site-specific DNA cleavage agents \* presents developments in DNA-binding zinc-finger protein, its DNA recognition, metal replacement, and structure and function \* delineates gene regulation by metals \* furnishes over 1200 bibliographic citations and some 200 drawings, tables, photographs, x-rays, and micrographs to assist research and aid more in-depth study of topics \* and more. Molecular Mechanism Of Metal-induced Mutagenicity And Carcinogenicity -- Regulation Of Nuclear Calcium And Zinc Interference By Toxic Metal Ions / Stefan Hechtenberg, Detmar Beyersmann -- Effects Of Antioxidants, Zinc, And Chelators On Free Radical Status Of Children Living In The Chernobyl Area / Ljudmila G. Korkina, Igor B. Afanas'ev -- The Role Of Ascorbate In Metabolism And Genotoxicity Of Chromium(vi) / Karen E. Wetterhahn, Diane M. Stearns, Manoj Misra, Paloma H. Giangrande, Laura S. Phieffer, Laura J. Kennedy, Kevin D. Courtney -- Inactivation Of Critical Cancer-related Genes By Nickel-induced Dna Hypermethylation And Increased Chromatin Condensation: A New Model For Epigenetic Carcinogenesis / Max Costa -- Oxidative Mechanisms Of Nickel(ii) And Cobalt(ii) Genotoxicity / Kazimierz S. Kasprzak -- The Antimutagenic Effects Of Metallothionein May Involve Free Radical Scavening / E.i. Goncharova, T.g. Rossman -- Protection From Metal-induced Dna Damage By Metallothionein In An In Vitro System / Lu Cai, Jim Koropatnick, M. George Cherian -- Dna Strand Breakage And Lipid Peroxidation As Possible Mechanisms Of Selenium Toxicity / J. Kitahara, Y. Seko, N. Imura, H. Utsumi, A. Hamada -- Role Of Metal In Oxidative Dna Damage By Non-mutagenic Carcinogen / Shosuke Kawanishi, Shinji Oikawa, Sumiko Inoue -- Metal-dna, Dna Cleavage, And Zinc-finger Proteins -- Sequence-selective Cleavage Of Dna By Cationic Metalloporphyrins / Genevieve Pratviel, Pascal Bigey, Jean Bernadou, Bernard Meunier. Edited By Bibudhendra Sarkar. Includes Bibliographical References And Index. Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada, this unique resource -- the only book of its kind to focus on the effects of metals on DNA -- provides up-to-date information on new developments in the field and their wide-ranging implications. Discussing the molecular mechanisms of metal-induced mutagenicity and carcinogenicity, Genetic Response to Metals examines metal compounds that cleave DNA, their design, and mechanisms of action ... explores future applications for targeting site-specific DNA cleavage agents ... presents developments in DNA-binding zinc-finger protein, its DNA recognition, metal replacement, and structure and function ... describes the genes for Menkes and Wilson diseases ... offers new data on the pathophysiology of Menkes and Wilson diseases as well as new therapies ... elucidates the effects of metals and chelators on the free radical status of children living in the Chernobyl area ... delineates gene regulation by metals ... and more. Written by more than 80 international experts from various disciplines, Genetic Response to Metals is an incomparable reference for biochemists; geneticists; bioinorganic, inorganic, coordination, environmental, and medicinal chemists; immunologists; oncologists; pediatricians; physiologists; pharmacologists; toxicologists; enzymologists; environmental scientists; and graduate and medical school students in these disciplines "Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada. The only book of its kind to focus on the effects of metals on DNA. Provides up-to-date information on new developments in the field and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity." Based on the 1st International Symposium on Metals and Genetics held at the Hospital for Sick Children in Toronto, Ontario, Canada, this book focuses on the effects of metals on DNA. Providing the developments in the field and their wide-ranging implications, it discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity.