GENETIC CONTROL OF NATURAL RESISTANCE TO INFECTION AND MALIGNANCY : PROCEEDINGS OF AN INTERNATIONAL SYMPOSIUM OF THE CANADIAN SOCIETY FOR IMMUNOLOGY HELD IN MONTREAL, QUEBEC, MARCH 18-20, 1980

Genetic Control of Natural Resistance to Infection and Malignancy is a collection of papers presented at the 1980 Proceedings of an International Symposium of the Canadian Society for Immunology held in Montreal, Quebec. It provides information about the different models of genetic resistance to various diseases. The book offers an overview of the genetic determination of the susceptibility or resistance to infection and malignancy. It also discusses the importance of genetic resistance not only in the first-line observation of infections and tumors, but also in chemotherapy and immunotherapy. It then explains the genetic control of resistance to parasitic, bacterial, and virus infections, as well as to tumor growth. It further discusses the genetic control of macrophage differentiation and function. Content: Perspectives in Immunology: A Series of Publications Based on Symposia , Page ii Front Matter , Page iii Copyright , Page iv CONTRIBUTORS , Pages xi-xviii PREFACE , Pages xix-xx , Emil Skamene, Patricia A.L. Kongshavn ACKNOWLEDGMENTS , Page xxi RECOMBINANT INBRED STRAINS OF MICE: USE IN GENETIC ANALYSIS OF DISEASE RESISTANCE , Pages 1-7 , Benjamin A. Taylor GENETIC CONTROL OF RESISTANCE TO PROTOZOAL INFECTIONS , Pages 9-28 , David J. Bradley STUDIES ON THE GENETIC CONTROL OF VISCERAL LEISHMANIASIS IN BALB/c MICE BY L.TROPICA , Pages 29-37 , F.Z. Modabber, M. Alimohammadian, A. Khamesipour, M.H. Pourmand, M. Kamali, M. Nasseri INFECTION WITH LEISHMANIA TROPICA MAJORS: GENETIC CONTROL IN INBRED MOUSE STRAINS , Pages 39-45 , Louis J. DeTolla Jr., Phillip A. Scott, Jay P. Farrell THE RESPONSE TO THERAPEUTICAL TREATMENT OF RESISTANT AND SUSCEPTIBLE MICE INFECTED WITH LEISHMANIA MEXICANA , Pages 47-53 , Hilda Pérez, Fanny Labrador, Eliades Ledezma GENETIC CONTROL OF IMMUNOLOGICALLY MEDIATED RESISTANCE TO HELMINTHIC INFECTIONS , Pages 55-66 , DEREK WAKELIN VARIATION IN ANTI-TRICHINELLA RESPONSIVENESS IN INBRED MOUSE STRAINS , Pages 67-73 , R.G. Bell, D.D. McGregor MHC-LINKED GENETIC CONTROL OF THE IMMUNE RESPONSE TO PARASITES: TRICHINELLA SPIRALIS IN THE MOUSE , Pages 75-82 , Donald L. Wassom, Chella S. David, Gerald J. Gleich IMMUNOMODULATION AND ALTERED RESISTANCE TO INFECTION IN DIFFERENT MOUSE STRAINS INFECTED WITH NIPPOSTRONGYLUS BRASILIENSIS , Pages 83-88 , Ann C. Vickery, Thomas W. Klein, Herman Friedman GENETIC CONTROL OF NATURAL RESISTANCE TO TRYPANOSOMA RHODESIENSE IN MICE , Pages 89-95 , Hellen C. Greenblatt, David L. Rosenstreich, Carter L. Diggs GENETIC CONTROL OF RESISTANCE TO PARASITIC INFECTIONS: Chairman's Summary , Pages 97-99 , David L. Rosenstreich DIFFERENTIAL SENSITIVITY OF INBRED MICE TO SALMONELLA TYPHIMURIUM : A MODEL FOR GENETIC REGULATION OF INNATE RESISTANCE TO BACTERIAL INFECTION , Pages 101-114 , Alison D. O'Brien, David L. Rosenstreich, Eleanor S. Metcalf, Irwin Scher THE C3HeB/FeJ MOUSE, A STRAIN IN THE C3H LINEAGE WHICH SEPARATES SALMONELLA SUSCEPTIBILITY AND IMMUNIZABILITY FROM MITOGENIC RESPONSIVENESS TO LIPOPOLYSACCHARIDE , Pages 115-120 , Toby K. Eisenstein, Lynn W. Deakins, Barnet M. Sultzer NATURAL RESISTANCE TO MOUSE TYPHOID: POSSIBLE ROLE OF THE MACROPHAGE , Pages 121-132 , Carlos E. Hormaeche, James Brock, Richard Pettifor CONTROL OF RESISTANCE TO SALMONELLA TYPHIMURIUM IN HYBRID GENERATIONS OF INBRED MICE AND BIOZZI MICE , Pages 133-140 , Janet E. Plant, Alan A. Glynn A SINGLE GENE ( Lr ) CONTROLLING NATURAL RESISTANCE TO MURINE LISTERIOSIS , Pages 141-147 , Christina Cheers, I.F.C. McKenzie, T.E. Mandel, Yu Yu Chan CELLULAR MECHANISMS OF GENETICALLY DETERMINED RESISTANCE TO LISTERIA MONOCYTOGENES , Pages 149-163 , Patricia A.L. Kongshavn, Chitra Sadarangani, Emil Skamene GENETIC CONTROL OF NATURAL RESISTANCE TO RICKETTSIA TSUTSUGAMUSHI INFECTION IN MICE , Pages 165-171 , Michael G. Groves, David L. Rosenstreich, Joseph V. Osterman SUSCEPTIBILITY OF (CBA/N X DBA/2)F 1 MALE MICE TO INFECTION WITH TYPE 3 STREPTOCOCCUS PNEUMONIAE , Pages 173-177 , D. Briles, M. Nahm, K. Schroer, P. Baker, J. Davie GENETICALLY CONTROLLED NATURAL RESISTANCE OF MICE TO PLAGUE INFECTION AND ITS RELATIONSHIP TO GENETICALLY CONTROLLED CELL-MEDIATED IMMUNE RESISTANCE , Pages 179-184 , Akira Wake GENETIC CONTROL OF DELAYED-TYPE HYPERSENSITIVITY TO MYCOBACTERIUM BOVIS BCG INFECTION IN MICE , Pages 185-190 , Reiko M. Nakamura, Tohru Tokunaga GENETIC CONTROL OF BCG-INDUCED CHRONIC GRANULOMATOUS INFLAMMATION AND ANERGY , Pages 191-200 , Vernon L. Moore, John L. Sternick, Denis J. Schrier, Elizabeth M. Allen, Benjamin A. Taylor MURINE LEPROSY AS A MODEL FOR THE ANALYSIS OF GENETIC FACTORS CONTROLLING RESISTANCE TO MYCOBACTERIAL INFECTION , Pages 201-207 , Otto Closs, Martinus Lovik GENETIC CONTROL OF RESISTANCE TO BACTERIAL INFECTIONS: Chairman's Summary , Pages 209-214 , Emil Skamene IS GENETIC RESISTANCE TO MOUSE HEPATITIS BASED ON IMMUNOLOGICAL REACTIONS? , Pages 215-226 , Frederik B. Bang, Thornton S. Cody HOST DEFENSE MECHANISMS IN GENETIC RESISTANCE TO VIRAL INFECTIONS , Pages 227-239 , O. Haller, H. Arnheiter, J. Lindenmann GENETIC STUDY OF MHV3 INFECTION IN MICE: IN VITRO REPLICATION OF VIRUS IN MACROPHAGES , Pages 241-246 , C. Dupuy, D. Lafforêt-Cresteil, J.M. Dupuy GENETIC CONTROL OF RESISTANCE TO JHM, A NEUROTROPIC STRAIN OF MOUSE HEPATITIS , Pages 247-251 , Jeffrey A. Frelinger, Stephen A. Stohlman GENETIC RESISTANCE TO HERPESVIRUS INFECTIONS: ROLE OF NATURAL KILLER CELLS , Pages 253-265 , Carlos Lopez STUDIES OF RESISTANCE OF MICE AGAINST HERPES SIMPLEX VIRUS , Pages 267-276 , H. Kirchner, H. Engler, R. Zawatzky, C.H. Schroder ASSOCIATION OF HOST GENOTYPE WITH THE AUGMENTATION OF NATURAL KILLER CELLS AND RESISTANCE TO MURINE CYTOMEGALOVIRUS , Pages 277-282 , Gregory J. Bancroft, Geoffrey R. Shellam, Jane E. Chalmer GENETIC RESISTANCE TO MURINE CYTOMEGALOVIRUS INFECTION , Pages 283-290 , Jane E. Chalmer GENETICS OF MACROPHAGE-CONTROLLED NATURAL RESISTANCE TO HEPATITIS INDUCED BY HERPES SIMPLEX VIRUS TYPE 2 IN MICE , Pages 291-296 , Soren C. Mogensen GENETICALLY CONTROLLED RESISTANCE TO TOGAVIRUSES , Pages 297-303 , Margo A. Brinton GENETIC RESISTANCE TO LETHAL FLAVIVIRUS INFECTION: DETECTION OF INTERFERING VIRUS PRODUCED IN VIVO , Pages 305-312 , Abigail L. Smith, Robert O. Jacoby, Pravin N. Bhatt THE ROLE OF H-2 IN RESISTANCE AND SUSCEPTIBILITY TO MEASLES VIRUS INFECTION , Pages 313-320 , Bracha Rager-Zisman, P. Andrew Neighbour, Barry R. Bloom, Grace Ju Ir GENE REGULATION OF SENSITIVITY TO LEUKEMOGENESIS BY RadLV VARIANTS AND ITS RELATIONSHIP TO PRELEUKEMIC CELLS , Pages 321-328 , Peter Lonai, Emil Katz, Nechama Haran-Ghera RECOVERY FROM FRIEND VIRUS LEUKEMIA IS DETERMINED BY THE H-2 GENOTYPE OF NONLEUKEMIC CELLS OF THE SPLEEN AND BONE MARROW , Pages 329-335 , William J. Britt, Bruce Chesebro USE OF AN INFECTIOUS CENTER ASSAY TO STUDY Fv-2 r -MEDIATED RESISTANCE OF MOUSE BONE MARROW CELLS TO FRIEND SPLEEN FOCUS-FORMING VIRUS , Pages 337-343 , Richard Steeves, Chalobon Yoosook, Frank Lilly GENETICALLY ACQUIRED RESISTANCE TO FATAL PICHINDE VIRUS INFECTION IN THE SYRIAN HAMSTER , Pages 345-352 , Sydney R. Gee, Marcia A. Chan, David A. Clark, William E. Rawls SUBACUTE SCLEROSING PANENCEPHALITIS IN INBRED HAMSTERS , Pages 353-359 , R. Michael Massanari, Marcia L. Wilson, Joel R. Leininger MAREK'S DISEASE IN CHICKENS: GENETIC RESISTANCE TO A VIRAL NEOPLASTIC DISEASE. A REVIEW , Pages 361-365 , Jan S. Gavora, J. Lloyd Spencer RELATIONSHIP BETWEEN TUMORGENICITY AND IMMUNOSUPPRESSION IN RESISTANT AND SUSCEPTIBLE STRAINS OF MICE INFECTED WITH FRIEND LEUKEMIA VIRUS , Pages 367-371 , Steven Specter, Herman Friedman, Walter S. Ceglowski VIRAL IHIBITION OF LYMPHOCYTE MITOGENESIS: IMMUNOLOGICAL CHARACTERIZATION OF AN INHIBITORY FACTOR DERIVED FROM ADHERENT CELLS , Pages 373-379 , Evelyne Israel, Mark A. Wainberg GENETIC CONTROL OF NATURAL RESISTANCE TO VIRAL INFECTIONS: Chairman's Summary , Pages 381-387 , D. Bernard Amos GENETIC CONTROL OF IN VITRO NK REACTIVITY AND ITS RELATIONSHIP TO IN VIVO TUMOR RESISTANCE , Pages 389-404 , Rolf Kiessling, Klas Karre, Gunnar Klein DIFFERENT GENES REGULATE TUMOR CELL RECOGNITION AND CYTOLYSIS BY NK CELLS IN THE MOUSE , Pages 405-412 , John C. Roder HETEROGENEITY OF NATURAL KILLER CELLS: A SEROLOGICAL STUDY WITH SPECIFIC ANTI-NK ALLOANTISERA , Pages 413-418 , Robert C. Burton, Scott P. Bartlett, Henry J. Winn THE CHEDIAK-HIGASHI GENE IN HUMANS CONTROLS NK FUNCTION , Pages 419-424 , Tina Haliotis, John C. Roder ANALYSIS OF THE GENETIC CONTROL OF NATURAL KILLER CELL ACTIVITY MAY REQUIRE STUDIES OF GENETICS WITH SEGREGATING ALLELES AMONG LITTERMATES , Pages 425-430 , R. Michael Williams, Roger Melvold GENETIC RESISTANCE TO TUMORS: ROLES OF MARROW-DEPENDENT AND -INDEPENDENT CELLS , Pages 431-443 , Michael Bennett, Vinay Kumar, Elinor Levy, Pamela Rodday H-2 DEPENDENT AND INDEPENDENT NATURAL RESISTANCE TO LEUKAEMIA TRANSPLANTATION IN IRRADIATED AND NONIRRADIATED MICE , Pages 445-454 , George A. Carlson, Grant Campbell NATURAL SURVEILLANCE OF NK-RESISTANT TUMORS. THE ROLE OF NATURAL ANTI-TUMOR ANTIBODY (NAb) AND MACROPHAGES (mph) , Pages 455-460 , Arnold H. Greenberg, Donna A. Chow, Liliana B. Wolosin DIFFERENTIAL TUMOR SUSCEPTIBILITY AND IMMUNE RESPONSIVENESS IN HRS/J MICE , Pages 461-466 , David A. Johnson, H.G. Bedigian, Hans Meier HYBRID RESISTANCE TO PARENTAL TUMORS: INFLUENCE OF HOST AND TUMOR GENOTYPE AND TUMOR DERIVATION , Pages 467-475 , Gunnar O. Klein, George Klein, Rolf Kiessling PRELIMINARY ANALYSIS OF HYBRID RESISTANCE TO HISTOCOMPATIBLE P815 UTILIZING BONE MARROW AND THYMUS EPITHELIUM RADIATION CHIMERAS , Pages 477-483 , R. Michael Williams, Blair M. Eig, Daniel E. Singer GENETIC CONTROL OF NATURAL RESISTANCE TO GRAFT VERSUS HOST-ASSOCIATED SUPPRESSION OF T CELL-MEDIATED LYMPHOLYSIS , Pages 485-494 , Gene M. Shearer, Richard P. Polisson, Matthew W. Miller, Elena Cudkowicz GENETIC CONTROL OF NATURAL RESISTANCE TO TUMOR GROWTH: Chairman's Summary , Pages 495-498 , Henry J. Winn THE GENETIC BASIS OF MACROPHAGE COLONY FORMATION , Pages 499-509 , Carleton C. Stewart, Emil Skamene, Patricia A.L. Kongshavn AN LPS RESPONSIVE CELL IN C3H/HeJ MICE: THE PERITONEAL EXUDATE-DERIVED MACROPHAGE COLONY-FORMING CELL (M-CFC) , Pages 511-518 , T.J. MacVittie, S.R. Weinberg ACTIVITY OF MACROPHAGE CELL LINES IN SPONTANEOUS AND LPS, LYMPHOKINE OR ANTIBODY-DEPENDENT KILLING OF TUMOR TARGETS , Pages 519-529 , Peter Ralph, Ilona Nakoinz, Jane E.R. Potter, Malcolm A.S. Moore MACROPHAGE CELL LINE MUTANTS DEFICIENT IN PHAGOCYTOSIS HAVE REDUCED PINOCYTIC ACTIVITY , Pages 531-535 , Allen J. Norin MACROPHAGE ACTIVATION FOR TUMOR CYTOTOXICITY: GENETIC INFLUENCES ON DEVELOPMENT OF MACROPHAGES WITH NONSPECIFIC TUMORICIDAL ACTIVITY , Pages 537-554 , Monte S. Meltzer, Luigi P. Ruco, Diana Boraschi, Daniela N. Mannel, Michael C. Edelstein ACTIVATED MACROPHAGES IN NATURAL RESISTANCE TO RICKETTSIA AKARI , Pages 555-563 , Carol A. Nacy, Georgiene Radlick, Monte S. Meltzer MACROPHAGE INFLAMMATORY RESPONSES IN LISTERIA-RESISTANT AND LISTERIA-SENSITIVE MICE , Pages 565-574 , Mary M. Stevenson, Patricia A.L. Kongshavn, Emil Skamene THE BEIGE (CHEDIAK-HIGASHI SYNDROME) MOUSE AS A MODEL FOR MACROPHAGE FUNCTION STUDIES , Pages 575-582 , Page S. Morahan, Stephen S. Morse, Keith H. Mahoney DEFECTIVE Fc-MEDIATED PHAGOCYTOSIS BY LPS-HYPORESPONSIVE ( Lps d ) C3H/HeJ MACROPHAGES: CORRECTION BY AGENTS THAT ELEVATE INTRACELLULAR CYCLIC AMP , Pages 583-589 , Stefanie N. Vogel, Lynda L. Weedon, Joost J. Oppenheim, David L. Rosenstreich GENETIC CONTROL OF MACROPHAGE DIFFERENTIATION AND FUNCTION: Chairman's Summary , Pages 591-594 , Peter Ralph INDEX , Pages 595-598