Genetic Causes of Cardiac Disease (Cardiac and Vascular Biology, 7)

This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives. The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists. Front Matter ....Pages i-vi Genetics of Adult and Fetal Forms of Long QT Syndrome (Lia Crotti, Alice Ghidoni, Federica Dagradi)....Pages 1-43 The Genetic Landscape of Cardiomyopathies (Brenda Gerull, Sabine Klaassen, Andreas Brodehl)....Pages 45-91 Genetic Basis of Mitochondrial Cardiomyopathy (Elisa Mastantuono, Cordula Maria Wolf, Holger Prokisch)....Pages 93-139 The Genetics of Coronary Heart Disease (Jeanette Erdmann, Maria Loreto Muñoz Venegas)....Pages 141-168 Complex Genetics and the Etiology of Human Congenital Heart Disease (Richard W. Kim, Peter J. Gruber)....Pages 169-184 Familial Hypercholesterolemia (Ashish Sarraju, Joshua W. Knowles)....Pages 185-198 Long Noncoding RNAs in Cardiovascular Disease (Lesca M. Holdt, Alexander Kohlmaier, Daniel Teupser)....Pages 199-288 Mouse Models to Study Inherited Cardiomyopathy (Mohammad Bakhtiar Hossain, Mohammad Bohlooly-Y, Ralph Knöll)....Pages 289-312 Interrogating Cardiovascular Genetics in Zebrafish (Jiandong Liu, Marc Renz, David Hassel)....Pages 313-339 Human Induced Pluripotent Stem Cells as Platform for Functional Examination of Cardiovascular Genetics in a Dish (Ralf Dirschinger, Tatjana Dorn, Alessandra Moretti)....Pages 341-357 Systems Medicine as a Transforming Tool for Cardiovascular Genetics (Melanie Boerries, Tanja Zeller)....Pages 359-379 Sex Differences in Prevalent Cardiovascular Disease in the General Population (Daniel Engler, Natascha Makarova, Renate B. Schnabel)....Pages 381-406