Genes, development, and cancer : the life and work of Edward B. Lewis

Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. His Nobel Prize winning studies founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. A lesser-known aspect of Lewis' canon is the pioneering studies he carried out on ionizing radiation and human cancer. In doing so, he was propelled into a public storm over nuclear weapons testing policy. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume. The Second Edition has been expanded with new material and the commentaries have been updated. Front Matter....Pages i-xlvi Front Matter....Pages 26-43 Star-Recessive, a Spontaneous Mutation in Drosophila Melanogaster ....Pages 45-48 Another Case of Unequal Crossing Over in Drosophila Melanogaster ....Pages 49-53 The Relation of Repeats to Position Effect in Drosophila Melanogaster ....Pages 55-84 The pseudoallelism of white and apricot in Drosophila melanogaster ....Pages 85-92 Pseudoallelism and Gene Evolution....Pages 93-115 The Theory and Application of a New Method of Detecting Chromosomal Rearrangements in Drosophila Melanogaster ....Pages 117-131 Some Aspects of Position Pseudoallelism....Pages 133-149 Genes and Gene Complexes....Pages 151-176 Front Matter....Pages 178-198 Genes and Developmental Pathways....Pages 199-228 A Gene Complex Controlling Segmentation in Drosophila ....Pages 229-242 Genetic Control of Body Segment Differentiation in Drosophila....Pages 243-261 Control of Body Segment Differentiation in Drosophila by the Bithorax Gene Complex....Pages 263-278 Regulation of the Genes of the Bithorax Complex in Drosophila ....Pages 279-296 Front Matter....Pages 298-310 Molecular Genetics of the Bithorax Complex in Drosophila Melanogaster ....Pages 311-326 The Abdominal Region of the Bithorax Complex....Pages 327-357 Transabdominal , A Dominant Mutant of the Bithorax Complex, Produces a Sexually Dimorphic Segmental Transformation in Drosophila ....Pages 359-381 Molecular Basis of Transabdominal—A Sexually Dimorphic Mutant of the Bithorax Complex of Drosophila ....Pages 383-391 Sequence Analysis of the Cis -Regulatory Regions of the Bithorax Complex of Drosophila ....Pages 393-402 Splits in Fruitfly Hox Gene Complexes....Pages 403-405 Evolution of the Homeobox Complex in the Diptera....Pages 407-411 Front Matter....Pages 414-431 Leukemia and Ionizing Radiation....Pages 433-451 Thyroid radiation doses from fallout....Pages 453-457 Leukemia, multiple myeloma, and aplastic anemia in american radiologists....Pages 459-466 Ionizing Radiation and Tumor Production....Pages 467-480 Leukemia, Radiation, and Hyperthyroidism....Pages 481-482 Analysis of Lung Tumor Mortality in the Battelle Beagle Lifespan Experiment....Pages 483-493 Ionizing Radiation, Cancer Induction, and Radioactive Fallout....Pages 495-502 Front Matter....Pages 503-503 Homeosis: the first 100 years....Pages 505-510 Remembering Sturtevant....Pages 511-516 C. B. Bridges' Repeat Hypothesis and the Nature of the Gene....Pages 517-525 Did Demerec Discover Intragenic Recombination in 1928?....Pages 527-530 The Bithorax Complex: The First Fifty Years....Pages 539-563 Back Matter....Pages 565-597 Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. His Nobel Prize winning studies founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. A lesser-known aspect of Lewis' canon is the pioneering studies he carried out on ionizing radiation and human cancer. In doing so, he was propelled into a public storm over nuclear weapons testing policy. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume. Howard Lipshitz, a close colleague during the last 20 years of Lewis' life, provides commentaries on the papers, placing them in their scientific and historical context and, throughout, giving insight into Lewis' approach to science and the motivations that drove Lewis' choice of subject matter. This book will be invaluable to a wide audience of professionals in the life and biomedical sciences; including geneticists, developmental biologists, molecular biologists, radiation biologists and cancer researchers. It provides source material for advanced undergraduate and graduate level courses in genetics, developmental biology, radiation and cancer. In addition, historians of science will find it to be a valuable resource both because it contains original research publications and because of the illuminating commentary. The Second Edition has been expanded with new material and the commentaries havebeen updated Comments on the First Edition: A great book that is of interest to many geneticists, developmental biologists, and historians of science. (Prof. Matthew P. Scott - Stanford University) A wonderful compendium of Lewis' papers. Lipshitz has done an outstanding job of summarizing and in many cases clarifying Lewis' writings. (Prof. James F. Crow, University of Wisconsin, Madison) A very valuable reference for those studying developmental biology, radiation and cancer. (Dr. Susan Celniker, Lawrence Berkeley National Laboratory, Berkeley, California) An excellent resource for understanding the emergence of developmental genetics. (Prof. Siegfried Roth, University of K??ln, Germany) Since the best way to become a good scientist is to understand how scientific ideas have been born and have developed, this book should be read by all graduate students in the areas of genetics, development and evolution. (Prof. Markus Noll, University of Zurich, Switzerland) This second edition collects Nobel Prize winner Edward B. Lewis’s key publications in the fields of genetics, developmental biology, radiation and cancer. Editor Howard Lipshitz, a close colleague during the last 20 years of Lewis's life, places the papers in their scientific and historical context and provides insight into Lewis's approach to science and the motivations that drove his choice of subject matter. Edited With Commentary By Howard D. Lipshitz. Includes Bibliographical References And Index.