Genes and Environment in Cancer (Recent Results in Cancer Research, 154)

Different cancer types can result from a multiplicity of environmental and genetic factors. Molecular epidemiology has focused recently on elucidating relationships between particular genetic alterations and the type of environmental exposure. Several genes have been identified as strong determinants for a number of cancer types. The incomplete penetrance often evidenced by mutations of these genes has raised the possibility that additional endogenous or exogenous determinants are involved in cancer development or suppression. The major aim of this book is to present an integrated view of environmental, epidemiological, and genetic determinants that contribute to cancer susceptibility and progression. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Epidemiological Evidence of the Effects of Behaviour and the Environment on the Risk of Human Cancer....Pages 3-21 Molecular Epidemiology of Human Cancer....Pages 22-36 Front Matter....Pages 37-37 Molecular Epidemiology of Environmental Carcinogenesis....Pages 39-46 Polymorphisms of N-Acetyltransferases, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility....Pages 47-85 Impact of Adduct Determination on the Assessment of Cancer Susceptibility....Pages 86-96 Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes....Pages 97-124 Front Matter....Pages 125-125 Relevance of DNA Repair to Carcinogenesis and Cancer Therapy....Pages 127-146 Molecular Basis of DNA Repair Mechanisms and Syndromes....Pages 147-155 The Ataxia Telangiectasia Gene in Familial and Sporadic Cancer....Pages 156-173 Front Matter....Pages 175-175 Cancer Predictive Value of Cytogenetic Markers Used in Occupational Health Surveillance Programs....Pages 177-184 Instability at Chromosomal Fragile Sites....Pages 185-199 The Role of Deletions at the FRA3B/FHIT Locus in Carcinogenesis....Pages 200-215 Gene Amplification Mechanisms: The Role of Fragile Sites....Pages 216-226 Front Matter....Pages 227-227 Mechanisms of Development of Multiple Endocrine Neoplasia Type 2 and Hirschsprung’s Disease by ret Mutations....Pages 229-236 Rearrangements of RET and NTRK1 Tyrosine Kinase Receptors in Papillary Thyroid Carcinomas....Pages 237-247 Molecular Genetics of Childhood Papillary Thyroid Carcinomas After Irradiation: High Prevalence of RET Rearrangement....Pages 248-264 Thyroid Carcinomas in RET/PTC Transgenic Mice....Pages 265-270 Signal Transduction by the Receptor Tyrosine Kinase Ret....Pages 271-281 Front Matter....Pages 283-283 Complex Traits on the Map....Pages 285-291 Genetic Mapping of Cancer Susceptibility/Resistance Loci in the Mouse....Pages 292-297 Front Matter....Pages 283-283 Cancer Epidemiology in Migrant Populations....Pages 298-305 Molecular Epidemiology of Hereditary Nonpolyposis Colorectal Cancer in Finland....Pages 306-311 Front Matter....Pages 313-313 The PreS2 Activators of the Hepatitis B Virus: Activators of Tumour Promoter Pathways....Pages 315-329 Antiviral Cell-Mediated Immune Responses During Hepatitis B and Hepatitis C Virus Infections....Pages 330-336 The Role of Hepatitis C Virus in Hepatocellular Carcinoma....Pages 337-344 Overview of Viruses, Cancer, and Vaccines in Concept and in Reality....Pages 345-362 Back Matter....Pages 363-369 Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as'cancer'.