Gene Therapy of Cochlear Deafness: Present Concepts and Future Aspects (Advances in Oto-Rhino-Laryngology, Vol. 66)

Gene therapy holds great potential for the treatment not only of genetic disorders, but also of many acquired diseases. This is as true for the inner ear as for any other organ. However, the technical challenges that must be overcome before gene therapy becomes more widely used are remarkable. In the inner ear the size, accessibility, delicacy and the involvement of many different cell types present unique conditions. This volume reviews current concepts and recent research findings of the application of gene therapy to the inner ear. Various forms of gene therapy, disorders that are potential targets for gene therapy, techniques for gene delivery, and mechanisms of gene targeting, and also obstacles that have yet to be overcome are discussed. This volume will be indispensable reading for otolaryngologists, hearing scientists, audiologists with a special interest in keeping up-to-date on gene therapy for inner ear disorders. Cover......Page 1 Contents......Page 6 Gene Therapy for the Inner Ear:Challenges and Promises......Page 8 Therapeutic Regulation of Gene Expression in the Inner Ear using RNA Interference......Page 20 Gene Therapy in the Inner Ear Using Adenovirus Vectors......Page 44 Repair of the Vestibular System via Adenovector Delivery of Atoh1: A Potential Treatment for Balance Disorders......Page 59 Gene Therapy and Stem Cell Transplantation:Strategies for Hearing Restoration......Page 71 Adenoviral and AAV-Mediated Gene Transfer to the Inner Ear: Role of Serotype, Promoter, and Viral Load on In Vivo and In Vitro Infection Efficiencies......Page 94 Cellular Targeting for Cochlear Gene Therapy......Page 106 Author Index......Page 123 Subject Index......Page 124 Gene therapy for the inner ear : challenges and promises / Ryan, A.F., Dazert, S. Therapeutic regulation of gene expression in the inner ear using RNA interference / Maeda, Y., Smith, R.J.H. Gene therapy of the inner ear using adenovirus vectors / Husseman, J., Raphael, Y. Repair of the vestibular system via adenovector delivery of Atoh1 : a potential treatment for balance disorders / Baker, K., Brough, D.E., Staecker, H. Gene therapy and stem cell transplantation : strategies for hearing restoration / Kesser, B.W., Lalwani, A.K. Adenoviral and AAV-mediated gene transfer to the inner ear : role of serotype, promoter, and viral load on in vivo and in vitro infection efficiencies / Luebke, A.E. ... [et al.]. "This volume reviews current concepts and recent research findings of the application of gene therapy to the inner ear. Various forms of gene therapy, disorders that are potential targets for gene therapy, techniques for gene delivery, and mechanisms of gene targeting, and also obstacles that have yet to be overcome are discussed."--Jacket