Gene Regulation and Therapeutics for Cancer

Advances in biotechnology have brought gene therapy to the forefront of medical research. The prelude to successful gene therapy, i.e. the efficient transfer and expression of a variety of human genes into target cells, has already been accomplished in several systems. Specifically, gene regulation and targeted therapy are essential for cancer and thus gene regulation and therapeutics are a practical addition to the arsenal of approaches to many human therapies in the 21st century. This book focuses on specific gene regulation and therapeutics in various cancers and new technology used in the field, giving an overall picture to scientists and physicians who are working in cancer research. Cover Title Page Copyright Page Preface Table of Contents 1. Programmed Death 1 Receptor (PD-1)-mediated Immunomodulatory Effects in Pancreatic Cancer 2. Nuclear Factor Kappa-B: Bridging Inflammation and Cancer 3. The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma 4. Nuclear Receptor Coactivators: Mechanism and Therapeutic Targeting in Cancer 5. Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection 6. Targeting Subgroup-specific Cancer Epitopes for Effective Treatment of Pediatric Medulloblastoma 7. Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas 8. Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers 9. Molecular Drivers in Lung Adenocarcinoma: Therapeutic Implications 10. Molecular Mediator of Prostate Cancer Progression and Its Implication in Therapy 11. Therapeutic Options for Prostate Cancer: A Contemporary Update 12. Regulation and Targeting of MUCINS in Pancreatic Cancer 13. Targeted Therapy for Cancer Stem Cells Index "Advances in biotechnology have brought gene therapy to the forefront of medical research. The prelude to successful gene therapy i.e. the efficient transfer and expression of a variety of human gene into target cells has already been accomplished in several systems. More specifically gene regulation and targeted therapy are essential for cancer. So definitely gene regulation and therapeutics are a practical addition to the arsenal of approaches to many human therapies in the 21st century. Our book focused on specific gene regulation and therapeutics in different cancers. Worldwide several scientists are working in gene regulation and therapeutics, and this is an exciting time for cancer research. Therefore, the focus of our book will give the overall idea to scientists who are working in cancer research"-- Provided by publisher Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.