Gene Expression and Its Discontents : The Social Production of Chronic Disease

A Cognitive Paradigm For Gene Expression, Via The Asymptotic Limit Theorems Of Information Theory, Allows Better Understanding Of How Embedding Context Affects The Development Of Organisms. In Sum, Epigenetic Information Sources Act As Tunable Catalysts, Directing Ontogeny Into Characteristic Pathways, A Perspective Having Important Implications For Epigenetic Epidemiology. The Authors Show How Environmental Stressors, In A Large Sense, Can Induce A Broad Spectrum Of Developmental Dysfunctions, And Examine A Number Of Pandemic Chronic Diseases, Using U.s. Data At Different Scales On The Effects Of The Legacy Of Slavery Compounded By Accelerating Industrial And Urban Decay. Developmental Disorders, Broadly Taken, Are Unlikely To Respond To Medical Interventions In The Face Of Serious, Persistent Individual And Community Stress. In Particular, Drugs Powerful Enough To Affect Deleterious Epigenetic Programming Will Likely Trigger Side Effects Leading To Shortened Lifespan. The Address Of Pandemic Chronic Disease Requires Significant Large-scale Changes In Public Policy And Resource Allocation. 1 Introduction; 2 Models Of Development; 3 Groupoid Symmetries; 4 Epigenetic Catalysis; 5 Developmental Disorders; 6 An Interim Perspective; 7 The Obesity Pandemic In The Us; 8 Coronary Heart Disease In The Us; 9 Cancer: A Developmental Perspective; 10 Autoimmune Disorders; 11 Demoralization And Obesity In Upper Manhattan; 12 Death At An Early Age: Aids And Related Mortality In New York City; 13 Final Thoughts; 14 Mathematical Appendix; 15 References; Index. Rodrick Wallace, Deborah Wallace. Includes Bibliographical References And Index. "A cognitive paradigm for gene expression, via the asymptotic limit theorems of information theory, allows better understanding of how embedding context affects the development of organisms. In sum, epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. The authors show how environmental stressors, in a large sense, can induce a broad spectrum of developmental dysfunctions, and examine a number of pandemic chronic diseases, using U.S. data at different scales on the effects of the legacy of slavery compounded by accelerating industrial and urban decay. Developmental disorders, broadly taken, are unlikely to respond to medical interventions in the face of serious, persistent individual and community stress. In particular, drugs powerful enough to affect deleterious epigenetic programming will likely trigger side effects leading to shortened lifespan. The address of pandemic chronic disease requires significant large-scale changes in public policy and resource allocation."--Jacket Annotation Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation Front Matter....Pages i-vii Introduction....Pages 1-26 Models of development....Pages 27-35 Groupoid symmetries....Pages 37-43 Epigenetic catalysis....Pages 45-57 Developmental disorders....Pages 59-67 An interim perspective....Pages 69-71 The obesity pandemic in the US....Pages 73-97 Coronary heart disease in the US....Pages 99-109 Cancer: a developmental perspective....Pages 111-119 Autoimmune disorders....Pages 121-142 Demoralization and obesity in Upper Manhattan....Pages 143-160 Death at an early age: AIDS and related mortality in New York City....Pages 161-180 Final thoughts....Pages 181-182 Mathematical appendix....Pages 183-200 References....Pages 201-224 Back Matter....Pages 1-3 This volume examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner.