Galanin : a new multifunctional peptide in the neuro-endocrine system : proceedings of an international symposium at the Wenner-Gren Center, Stockholm, June 14-16, 1990

This is the first-ever book dedicated solely to Galanin. It covers Galanin's biochemistry, distribution, receptors, neuro-endocrinology and functions within the nervous system. Front Matter....Pages i-xvii Front Matter....Pages 1-1 Discovery of galanin....Pages 3-15 On the solution structure of galanin....Pages 17-25 Cloning and expression of porcine and bovine galanin....Pages 27-36 Galanin gene expression....Pages 37-42 Neuroendocrine regulation of galanin gene expression....Pages 43-65 Front Matter....Pages 67-67 Localization of galanin cell bodies in the brain by immunocytochemistry and in situ hybridization histochemistry....Pages 69-92 Distribution of galanin binding sites in the central nervous system....Pages 93-106 Coexistence of galanin-like immunoreactivity with classical transmitters and other neuropeptides in the CNS....Pages 107-116 Galanin: Distribution, ontogeny and expression following manipulation of the endocrine and nervous systems....Pages 117-134 Galanin in enteric neurons....Pages 135-147 Front Matter....Pages 149-149 An overview of galanin’s actions on the endocrine pancreas....Pages 151-176 Galanin and the regulation of insulin secretion....Pages 177-184 Structure-function relationships of galanin....Pages 185-196 Front Matter....Pages 197-197 The galanin receptor: Functional and molecular characterization in the pancreatic beta cell....Pages 199-211 Galanin receptor ligands in the hippocampus: Galanin, N-terminal galanin fragments and analogs....Pages 213-220 Galanin/5-HT interactions in the rat central nervous system. Relevance for depression....Pages 221-235 Galanin inhibits β-cell electrical activity by a G-protein-regulated sulphonylurea-insensitive mechanism....Pages 237-245 Galanin regulation of acetylcholine release and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus....Pages 247-258 Front Matter....Pages 259-259 Galanin in a parasympathetic ganglion....Pages 261-274 Galanin and gastrointestinal function....Pages 275-286 Front Matter....Pages 259-259 Galanin in primary sensory neurons: Response to lesions....Pages 287-293 Galanin in sensory functions....Pages 295-303 Front Matter....Pages 305-305 Role of galanin in control of hypothalamic pituitary function....Pages 307-319 Role of galanin in prolactin and growth hormone secretion in rats....Pages 321-329 On the interations of galanin within the hypothalamic-pituitary axis of the rat....Pages 331-341 Galanin and the control of growth hormone secretion in man....Pages 343-354 Front Matter....Pages 355-355 The functions of galanin in the septo-hippocampal system of the adult and the aged rat: Electrophysiological and anatomical observations....Pages 357-366 Galanin reduces anoxic release of glutamate by an action on ATP sensitive K+ channels....Pages 367-376 Behavioral actions of galanin and galanin fragments....Pages 377-392 Hypothalamic galanin in relation to feeding behavior and endocrine systems....Pages 393-406 Galanin in the primate CNS and dementing neurologic diseases....Pages 407-417 Senile dementia of the Alzheimer type is accompanied by hypertrophy of galanin axons, reservation of receptors and tissue specific expression of the galanin gene in the nucleus basalis Meynert....Pages 419-427 Back Matter....Pages 429-433 This is a collection of articles dedicated to the recently discovered peptide, Galanin. The book covers Galanin's biochemistry, distribution, neuro-endocrinology and functions within the nervous system. This book is aimed at both professionals and students.