Gaba in Autism and Related Disorders (Volume 71) (International Review of Neurobiology, Volume 71)

Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians. * Discusses the neuropathology of the GABA system in autism * Presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism * Includes information on the shared genetic risk factors between autism and major mental disorders * Foreword by Eugene Roberts Content: Autism: Neuropathology, Alterations of the GABA ergic System, and Animal Models Review Article Pages 1-26 Imke A.J. van Kooten, Patrick R. Hof, Herman van Engeland, Harry W.M. Steinbusch, Paul H. Patterson, Christoph Schmitz The Role of GABA in the Early Neuronal Development Review Article Pages 27-62 Marta Jelitai, Emília Madarasz GABA ergic Signaling In The Developing Cerebellum Review Article Pages 63-94 Chitoshi Takayama Insights into GABA functions in the developing cerebellum Review Article Pages 95-112 Mónica L. Fiszman Role of GABA in the Mechanism of the Onset of Puberty in Non‐Human Primates Review Article Pages 113-129 Ei Terasawa Rett Syndrome: A Rosetta Stone for Understanding the Molecular Pathogenesis of Autism Review Article Pages 131-165 Janine M. LaSalle, Amber Hogart, Karen N. Thatcher GABA ergic Cerebellar System In Autism: A Neuropathological And Developmental Perspective Review Article Pages 167-178 Gene J. Blatt Reelin Glycoprotein in Autism and Schizophrenia Review Article Pages 179-187 S. Hossein Fatemi Is There A Connection Between Autism, Prader‐Willi Syndrome, Catatonia, And GABA? Review Article Pages 189-216 Dirk M. Dhossche, Yaru Song, Yiming Liu Alcohol, GABA Receptors, and Neurodevelopmental Disorders Review Article Pages 217-237 Ujjwal K. Rout Effects of secretin on extracellular GABA and other amino acid concentrations in the rat hippocampus Review Article Pages 239-271 Hans‐Willi Clement, Alexander Pschibul, Eberhard Schulz Predicted role of secretin and oxytocin in the treatment of behavioral and developmental disorders: implications for autism Review Article Pages 273-315 Martha G. Welch, David A. Ruggiero Immunological Findings in Autism Review Article Pages 317-341 Hari Har Parshad Cohly, Asit Panja Correlates of Psychomotor Symptoms in Autism Review Article Pages 343-357 Laura Stoppelbein, Sara Sytsma‐Jordan, Leilani Greening GABRB3 Gene Deficient Mice: A Potential Model of Autism Spectrum Disorder Review Article Pages 359-382 Timothy M. DeLorey The Reeler Mouse: Anatomy of a Mutant Review Article Pages 383-417 Gabriella D'Arcangelo Shared Chromosomal Susceptibility Regions Between Autism and Other Mental Disorders Review Article Pages 419-443 Yvon C. Chagnon Series Editors Page ii Contributors Pages xi-xiii Acknowledgments Page xxiii Preface Pages xix-xxii Foreword Pages xv-xviii Index Pages 445-464 Contents of Recent Volumes Pages 465-481 Contents Pages v-x Autism: neuropathology, alterations of the GABAergic system, and animal models Role of GABA in the early neuronal development GABAergic signaling in the developing cerebellum Insights into GABA functions in the developing cerebellum Role of GABA in the mechanism of the onset of puberty in non-human primates Rett syndrome: a rosetta stone for understanding the molecular pathogenesis of autism GABAergic cerebellar system in autism: a neuropathological and developmental perspective Reelin glycoprotein in autism and schizaphrenia Is there a connection between autism, prader-will syndrome, catatonia, and GABA? Alchol, GABA receptors, and Neurodevelopmenal disorders Effects of secretin on extracellular GABA and other amino acid concentrations in the rat hippocampus Predicted role of secretin and oxytocin in the treatment of behavioral and developmental disorders: implications for autism Hari har parshad cohly and asit panja Correlates of psychomotor symptoms in autism GABRB3 gene deficient mice: a potential model of autism spectrum disorder The reeler mouse: anatomy of a mutant Shared chromosomal susceptibility regions between autism and other mental disorders.