Future Aspects in Contraception : Proceedings of an International Symposium Held in Heidelberg, 5–8 September 1984 Part 2 Female Contraception

Front Matter....Pages i-xii Natural family planning....Pages 1-14 Barrier methods of contraception....Pages 15-22 Chemistry, contraceptive activity and toxicology of aryl guanidinobenzoates: inhibitors of sperm acrosin....Pages 23-29 Measurement of LH in saliva; a new approach to ovulation detection....Pages 31-47 Steroid-induced side-effects of oral contraceptives....Pages 49-62 Efficacy and physiology of a triphasic oral contraceptive....Pages 63-69 Advantages and disadvantages of low-dose hormonal contraceptive agents....Pages 71-82 Emerging routes of delivery for fertility-control agents....Pages 83-93 Current status of NORPLANT subdermal implants for contraception....Pages 95-106 New aspects in post-coital contraception....Pages 107-113 Biological evaluation of some medicinal plant extracts for contraceptive efficacy in females....Pages 115-128 Pharmacokinetic and antigenicity studies with LHRH analogues....Pages 129-147 LHRH nasal spray in contraception....Pages 149-160 Acute and intermittent LHRH agonist dosing as post-coital and anti-ovulatory contraceptive approaches....Pages 161-175 LHRH antagonists and contraception....Pages 177-187 Mechanism of action of gonadotrophin releasing hormone in the pituitary and gonads....Pages 189-201 Morphological changes on the surface of IUDS: Are they of clinical significance?....Pages 203-227 The use of non-culture tests for the detection of VD prior to IUD insertion: a view towards the future....Pages 229-234 Experience with GYNE-T Cu-380-A intrauterine contraceptive device (1981–1984)....Pages 235-237 Ten years’ experience with continuous use of the butterfly IUD....Pages 239-244 The antiprogesterone activity of RU 486, a contragestive agent in the human....Pages 245-248 Effects of the antiprogesterone RU 486 in early pregnancy and during the menstrual cycle....Pages 249-270 Prostaglandins in contraception....Pages 271-279 Ovarian hormones and cybernins....Pages 281-288 Biochemical aspects of a contraception model based on immunological properties of proteohormones....Pages 289-304 Variability in antisperm and antiembryonic humoral immune responses....Pages 305-317 Research for the development of an hCG antifertility vaccine....Pages 319-331 Present and future aspects of immunological methods in contraception....Pages 333-341 Preclinical and clinical aspects of safety in contraception....Pages 343-349 The politics of contraception....Pages 351-360 Contraceptive futurology: or 1984 in 1984....Pages 361-368 Back Matter....Pages 369-372 Atrophy of gonadotrophin producing cells Exogenously LH synthesis administered androgens and release or anabolic steroids are decreased Prostate Testes Normal function. Testosterone synthesis in The deficit of endogenously Leydig cells is decreased. The synthesized testosterone is exogenously administered compensated for by the steroid is not able to exogenously administered compensate for the deficit of steroid endogenously synthesized testosterone Figure 2 Intratesticular and serum testosterone concentrations after treatment with andro gens or anabolic steroids in order to substitute for the peripheral androgen deficiency and to achieve azoospermia. Because this steroid is alkylated in position 17, toxic effects on liver function can not be excluded. Danazol offers no advantages as compared with other anabolic steroids; rather, disadvantages. Numerous experiments of this type have been performed during the last 40 or 50 years. The outcome in each case was more or less identical: with a certain dose of an androgen or anabolic steroid it is possible to inhibit spermatogenesis without interfering with other androgen-dependent func tions, including libido (potentia coeundi) and accessory sexual glands. On the basis of this pharmacological-endocrinological background, androgens and anabolic steroids can be used for male fertility control, and several clinical trials have been performed during the last 10-15 years. Some of 1 these studies 2-23 are mentioned in Table 2