Future Aspects in Contraception: "Proceeding of an International Symposium held in Heidelberg, 5 - 8 September 1984 Part 1 Male Contraception"

Atrophy of gonadotrophin producing cells Exogenously LH synthesis administered androgens and release or anabolic steroids are decreased Prostate Testes Normal function. Testosterone synthesis in The deficit of endogenously Leydig cells is decreased. The synthesized testosterone is exogenously administered compensated for by the steroid is not able to exogenously administered compensate for the deficit of steroid endogenously synthesized testosterone Figure 2 Intratesticular and serum testosterone concentrations after treatment with andro­ gens or anabolic steroids in order to substitute for the peripheral androgen deficiency and to achieve azoospermia. Because this steroid is alkylated in position 17, toxic effects on liver function can not be excluded. Danazol offers no advantages as compared with other anabolic steroids; rather, disadvantages. Numerous experiments of this type have been performed during the last 40 or 50 years. The outcome in each case was more or less identical: with a certain dose of an androgen or anabolic steroid it is possible to inhibit spermatogenesis without interfering with other androgen-dependent func­ tions, including libido (potentia coeundi) and accessory sexual glands. On the basis of this pharmacological-endocrinological background, androgens and anabolic steroids can be used for male fertility control, and several clinical trials have been performed during the last 10-15 years. Some of 1 these studies 2-23 are mentioned in Table 2. Front Matter....Pages i-x Future aspects in contraception: an overview....Pages 1-127 Steroidal contraception — experimental background....Pages 129-144 Male contraception in the preclinical evaluation....Pages 145-152 Long-acting steroids for male contraception....Pages 153-166 Relationship between ligand structure and affinity for androgen binding protein....Pages 167-178 Male contraception with LHRH agonists....Pages 179-189 The epididymis as a target for contraception: role of testosterone metabolism....Pages 191-198 Effect of 6 month treatment with a gonadotrophin releasing hormone agonist analogue on endocrine and histological features of human testis tissue....Pages 199-204 The future of plant-derived chemicals as contraceptive agents....Pages 205-218 Gossypol—the male fertility-regulating agent....Pages 219-227 Cottonseed oil for birth control....Pages 229-236 Antifertility activity of (—)-gossypol....Pages 237-241 Monoclonal antibodies directed against human sperm antigens....Pages 243-250 Influence of psychotropic drugs, gossypol and acetylcholine receptor blockers on the motility of human spermatozoa in vitro ....Pages 251-255 Investigations on the spermicidal action of cellulose trisulphuric acid ester....Pages 257-265 Back Matter....Pages 267-270