Fundamental Aspects of Cancer (Cancer Growth and Progression Book 1)

Individual neoplastic diseases often show discrete growth direct effect of tumor metastases or to adverse consequences patterns subject to many modifications according to the associated with these therapeutic modes (e.g., complications stage of the disease, the species involved and the tumor type of immunosuppression which can lead to mortality arising concerned. Primary neoplasms are less difficult to treat in from infectious disease). contrast to secondary neoplasms. The chief type of secon­ It is therefore quite clear that there is a crucial need for dary neoplastic growth, metastasis, is also comparatively new methods for the detection of micrometastases and the development of new modalities for the treatment of estab­ less well understood. Phylogenetically, metastasis attains its highest level of development in the mammal and is best lished metastases. It is likely that such modalities must known in man, but is still far from being understood. overcome tumor heterogeneity and drug resistance to yield new therapeutic modalities with improved margin of safety The process of cancer growth and progression, from the initiation of neoplastic transformation of normal cells to the and efficacy over currently available anti-neoplastic drugs. Front Matter....Pages i-x The Biology of Human Cancer, and the Development of a Rational Basis for Treatment....Pages 1-22 Organ Culture: Use in Experimental Oncology for Comparisons Among Species....Pages 23-27 Overview of Current Understanding of Tumor Spread....Pages 28-32 Intraspecies and Interspecies Comparison....Pages 33-34 The Life Span of Mammals: A Comparison....Pages 35-40 The Culmination of Neoplastic Development in the Mammal....Pages 41-42 The Influence of the Body Structure on Tumor Development....Pages 43-46 The Evolution of Diversity within Tumors and Metastases....Pages 47-64 Neoplastic Heterogeneity and Clinical Chemotherapy....Pages 65-72 The Attraction of Wandering Metastatic Cells....Pages 73-83 Tumor-Cell Interactions with Blood Vessels during Cancer Metastasis....Pages 84-97 Comparative Importance of the Lymphatic System during Neoplastic Progression: Lymphohematogenous Spreading....Pages 98-133 Immunological Control of Tumor Metastases....Pages 134-143 Role of Macrophages in Recognition and Destruction of Metastatic Cells....Pages 144-155 Metastases from Metastasis: Clinical Relevance in Human Cancer....Pages 156-161 Treatment Research in Cancer....Pages 162-170 Chemotherapy from Animals to Man....Pages 171-191 Therapy of Metastasis in Animal Models....Pages 192-200 Back Matter....Pages 201-211