Functions and Biotechnology of Plant Secondary Metabolites (Annual Plant Reviews, Volume 39, 2nd Edition)

This important volume commences with an overview of the modes of action of defensive secondary metabolites, followed by detailed surveys of chemical defense in marine ecosystems, the biochemistry of induced defense, plant-microbe interactions and medical applications. A chapter is also included covering biotechnological aspects of producing valuable secondary metabolites in plant cell and organ cultures. This is a comprehensive and fully updated new edition, edited by Professor Michael Wink and including contributions from many internationally acknowledged experts in the field. ANNUAL PLANT REVIEWS VOLUME 39......Page 5 CONTENTS......Page 9 List of contributors......Page 11 Preface......Page 13 1.1 Ecological function of secondary metabolites......Page 17 1.2 Presence of defence and signal compounds at the right time and place......Page 20 1.3 Molecular modes of action of SM......Page 24 1.4 Biotechnology and utilization of SM......Page 29 1.5 Conclusions......Page 32 2.1 Introduction......Page 37 2.2 Molecular modes of action – an overview......Page 38 2.3 Accumulation of defence and signal compounds in plants......Page 151 2.4 Animal responses: detoxification mechanisms and adaptations......Page 155 2.5 Concluding remarks......Page 160 3.1 Introduction......Page 185 3.2 Marine natural products in allelopathic interactions......Page 188 3.3 Chemical defence against fouling......Page 191 3.4 Chemical defences of marine invertebrates and algae against consumers......Page 196 3.5 Favoured allocation of defensive metabolites in vulnerable and valuable parts of marine invertebrates and algae......Page 205 3.6 The flexible response: stress-induced accumulation of defence metabolites and activation of protoxins......Page 209 3.7 Endosymbionts as sources for allelochemicals found in marine invertebrates......Page 216 3.8 Conclusions and outlook......Page 224 4 Plant–Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties......Page 237 4.1 Introduction......Page 238 4.2 Phytoalexins......Page 240 4.3 Antibacterial and antifungal agents of higher plants......Page 255 4.4 Secondary metabolites from higher plants with antiviral properties......Page 301 4.5 Conclusions......Page 340 5 New Medical Applications of Plant Secondary Metabolites......Page 371 5.2 Compounds with anticancer and chemopreventive activity......Page 372 5.3 Antiviral compounds......Page 382 5.4 Antimalarial drugs......Page 383 5.5 Anti-inflammatory drugs......Page 384 5.6 Antidepressant drugs......Page 386 5.7 Anti-ischaemic drugs......Page 387 5.8 Immunostimulatory drugs......Page 388 5.9 Conclusions......Page 389 6.1 Introduction......Page 404 6.3 Elicitation......Page 406 6.4 Increase/decrease of product yields by genetic manipulation......Page 407 6.5 Biosynthetic pathways delineation using RNA-interference......Page 408 6.6 Mass cultivation of plant cell cultures......Page 409 6.7 Production of recombinant proteins by plants and plant cell cultures......Page 411 6.8 Production of plant natural products in microbes......Page 412 6.9 Perspectives......Page 413 Index......Page 422 Colour plate (between pages 50 and 51)......Page 67 This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Functions of Plant Secondary Metabolites and their Exploitation in Biotechnology (Annual Plant Reviews, Volume 3). This exciting new volume provides an up-to-date survey of the functions of plant secondary metabolites, their modes of action and their use in pharmacology as molecular probes, in medicine as therapeutic agents, and in agriculture as biorational pesticides. The possibilities to produce valuable natural products in plant cell and tissue culture and even in recombinant microorganisms are also reviewed. This carefully compiled new edition brings together chapters from some of the world's leading experts in plant secondary metabolites. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves. A companion volume Annual Plant Reviews Volume 40, Biochemistryof Plant Secondary Metabolism, Second Edition, Edited by M. Wink, is also available. "This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Functions of Plant Secondary Metabolites and their Exploitation in Biotechnology (Annual Plant Reviews, Volume 3). This exciting new volume provides an up-to-date survey of the functions of plant secondary metabolites, their modes of action and their use in pharmacology as molecular probes, in medicine as therapeutic agents, and in agriculture as biorational pesticides. The possibilities to produce valuable natural products in plant cell and tissue culture and even in recombinant microorganisms are also reviewed. This carefully compiled new edition brings together chapters from some of the world's leading experts in plant secondary metabolites. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves."--Publisher's description "This volume commences with an overview of the modes of action of defensive secondary metabolites, followed by detailed surveys of chemical defense in marine ecosystems, the biochemistry of induced defense, plant-microbe interactions and medical applications. A chapter is also included covering biotechnological aspects of producing valuable secondary metabolites in plant cell and organ cultures."--NHBS Environment Bookstore Modes of action / Michael Wink and Oskar Schimmer Chemical defense in marine systems / Annika Putz and Peter Proksch Plant-microbes / Jürgen Reichling Medical applications / Jörg Heilmann Cell and organ cultures / August-Wilhelm Alfermann. New edition of highly successful volume Part of Wiley-Blackwells's highly regarded Annual Plant Reviews Cutting edge reviews of core plant sciences topics Internationally well-known contributors.