Functional Neural Transplantation II. Novel Cell Therapies for CNS Disorders (Volume 127) (Progress in Brain Research, Volume 127)

Annotation The first edition of Functional Neural Transplantation , appearing in 1994, was commissioned to provide a systematic overview of the main areas of active research into the use of neural transplantation for functional repair at that time. There have though been major developments in the field over the last decade. First, whereas many of the model systems are the same, the sophistication of the research has developed dramatically. Secondly, there has been a major change in focus related to the nature of the optimal reparative process, moving away from a primary goal involving repair by replacement of lost cells, to strategies based on halting or reversing the disease process itself. Thirdly, the last decade has (not surprisingly) seen an expansion in the breadth of clinical applications for transplantation not only of primary embryonic neural tissues but also the initial applications of cells and cell lines. In order to address these recent developments as we enter the 21st century, 10 years after conception and 6 years after the publication of Functional Neural Transplantation , the Editors have now sought to co-ordinate and edit an updated version, Functional Neural Transplantation II . Functional Neural Transplantation II is not just a revised edition of the previous volume, but an entirely new and complementary second volume to update the field to 'state of the art' for the new millennium. For many major topic areas (such as functional repair in neurodegenerative disorders of the basal ganglia) there has been a continual flow of significant advances. Although these topics are covered in both volumes, the Editors have sought to avoid duplication by requiring that the present coverage emphasises the major developments over the last decade while relying on the first volume for the background overviews. Other topics though are entirely new in the present volume, such as novel applications of neural transplantation to other major clinical relevance such as retinal repair or alleviation of pain. A key departure of the present volume is the addition of several early chapters addressing the technical and developmental issues associated with identification of alternative sources of cells for transplantation - cell lines, immortalised cells, precursor/stem cells and xenotransplantation. Content: List of contributors Pages v-vii Preface Pages ix-xii Stephen Dunnett, Anders Björklund Chapter 1 The subventricular zone: source of neuronal precursors for brain repair Original Research Article Pages 1-11 Arturo Alvarez-Buylla, Daniel G. Herrera, Hynek Wichterle Chapter 2 Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation Original Research Article Pages 13-34 C.N. Svendsen, M.A. Caldwell Chapter 3 Activity-dependent regulation of neuronal plasticity and self repair Original Research Article Pages 35-48 Gerd Kempermann, Henriette van Praag, Fred H. Gage Chapter 4 Immortalized neural cell lines for CNS transplantation Original Research Article Pages 49-65 Scott R. Whittemore, Stephen M. Onifer Chapter 5 The chick/quail transplantation model to study central nervous system development Original Research Article Pages 67-98 Rosa-Magda Alvarado-Mallart Chapter 6 Novel mechanisms in mammalian telencephalic development as revealed by neural transplantation Original Research Article Pages 99-113 Kenneth Campbell, Martin Olsson Chapter 7 Reconstruction of cortical circuitry Original Research Article Pages 115-156 Monte A. Gates, Rosemary A. Fricker-Gates, Jeffrey D. Macklis Chapter 8 Xenotransplantation Original Research Article Pages 157-188 Erik Bo Pedersen, Håkan Widner Chapter 9 Encapsulated neural transplants Original Research Article Pages 189-202 Jack L. Tseng, Patrick Aebischer Chapter 10 Improving the survival of grafted embryonic dopamine neurons in rodent models of Parkinson's disease Original Research Article Pages 203-231 Roger F. Castilho, Oskar Hansson, Patrik Brundin Chapter 11 Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement Original Research Article Pages 233-265 Christian Winkler, Deniz Kirik, Anders Björklund, Stephen B. Dunnett Chapter 12 The primate model of Parkinson's disease: its usefulness, limitations, and importance in directing future studies Review Article Pages 267-297 Kimberly D. Bingaman, Roy A.E. Bakay Chapter 13 Clinical observations after neural transplantation in Parkinson's disease Original Research Article Pages 299-320 Olle Lindvall, Peter Hagell Chapter 14 Non-invasive in vivo imaging of transplant function Original Research Article Pages 321-332 David J. Brooks, Paola Piccini Chapter 15 Neuropathology of fetal nigra transplants for Parkinson's disease Original Research Article Pages 333-344 Jeffrey H. Kordower, Caryl E. Sortwell Chapter 16 The integration and function of striatal grafts Original Research Article Pages 345-380 Stephen B. Dunnett, Falguni Nathwani, Anders Björklund Chapter 17 Striatal tissue transplantation in non-human primates Original Research Article Pages 381-404 A.Lisa Kendall, Phillipe Hantraye, Stéphane Palfi Chapter 18 Neural transplantation for the treatment of Huntington's disease Original Research Article Pages 405-411 Thomas B. Freeman, Robert A. Hauser, Paul R. Sanberg, Samuel Saporta Chapter 19 Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Original Research Article Pages 413-430 Jeffrey H. Kordower, Ole Isacson, Liza Leventhal, Dwaine F. Emerich Chapter 20 Functional reconstruction of the hippocampus Original Research Article Pages 431-459 R.M. Ridley, H.F. Baker, H. Hodges Chapter 21 Restoration of function by neural transplantation in the ischemic brain Original Research Article Pages 461-476 Hitoo Nishino, Cesario V. Borlongan Chapter 22 Functional aspects of cerebellar transplantation Original Research Article Pages 477-488 Lazaros C. Triarhou Chapter 23 Preservation and restoration of vision following transplantation Original Research Article Pages 489-499 Peter J. Coffey, Simon J.O. Whiteley, Raymond D. Lund Chapter 24 Spinal cord motoneuron maintenance, injury and repair Original Research Article Pages 501-514 Thomas Carlstedt, Staffan Cullheim Chapter 25 Remyelination and restoration of axonal function by glial cell transplantation Original Research Article Pages 515-533 Su-Chun Zhang, Ian D. Duncan Chapter 26 The alleviation of pain by cell transplantation Original Research Article Pages 535-550 Ian D. Hentall, Jacqueline Sagen Subject index Pages 551-559

the First Edition Of functional Neural Transplantation, Appearing In 1994, Was Commissioned To Provide A Systematic Overview Of The Main Areas Of Active Research Into The Use Of Neural Transplantation For Functional Repair At That Time. There Have Though Been Major Developments In The Field Over The Last Decade. First, Whereas Many Of The Model Systems Are The Same, The Sophistication Of The Research Has Developed Dramatically. Secondly, There Has Been A Major Change In Focus Related To The Nature Of The Optimal Reparative Process, Moving Away From A Primary Goal Involving Repair By Replacement Of Lost Cells, To Strategies Based On Halting Or Reversing The Disease Process Itself. Thirdly, The Last Decade Has (not Surprisingly) Seen An Expansion In The Breadth Of Clinical Applications For Transplantation Not Only Of Primary Embryonic Neural Tissues But Also The Initial Applications Of Cells And Cell Lines.

in Order To Address These Recent Developments As We Enter The 21st Century, 10 Years After Conception And 6 Years After The Publication Of functional Neural Transplantation, The Editors Have Now Sought To Co-ordinate And Edit An Updated Version, functional Neural Transplantation Ii.

functional Neural Transplantation Ii Is Not Just A Revised Edition Of The Previous Volume, But An Entirely New And Complementary Second Volume To Update The Field To 'state Of The Art' For The New Millennium. For Many Major Topic Areas (such As Functional Repair In Neurodegenerative Disorders Of The Basal Ganglia) There Has Been A Continual Flow Of Significant Advances. Although These Topics Are Covered In Both Volumes, The Editors Have Sought To Avoid Duplication By Requiring That The Present Coverage Emphasises The Major Developments Over The Last Decade While Relying On The First Volume For The Background Overviews. Other Topics Though Are Entirely New In The Present Volume, Such As Novel Applications Of Neural Transplantation To Other Major Clinical Relevance Such As Retinal Repair Or Alleviation Of Pain. A Key Departure Of The Present Volume Is The Addition Of Several Early Chapters Addressing The Technical And Developmental Issues Associated With Identification Of Alternative Sources Of Cells For Transplantation - Cell Lines, Immortalised Cells, Precursor/stem Cells And Xenotransplantation.

Offers an overview of the main areas of active research into the use of neural transplantation for functional repair. This volume includes chapters addressing the technical and developmental issues associated with identification of alternative sources of cells for transplantation - cell lines, immortalised cells, and precursor/stem cells. Repair of a damaged brain by neuronal transplantation requires a sufficient source of immature neuronal precursors capable of integration and differentiation into appropriate cell types.