Frontiers In Ovarian Cancer Science (comprehensive Gynecology And Obstetrics)

This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the __WHO Classification of Tumors of Female Reproductive Organs__ was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades, making it essential to pursue multidisciplinary treatment and apply novel techniques such as neoadjuvant chemotherapy in daily clinical practice. The primary clinical task is the effective treatment of recurrent ovarian cancer with early palliative medicine. Fertility-sparing surgery may also be pursued depending on histologic subtypes, stage, extent of disease, and preexisting ovarian reserve with the concept of oncofertility.On the basis of the considerations described above, each expert author elucidates the science of ovarian cancer in detail, thus providing a collection that will benefit young medical oncologists and seasoned gynecologists and obstetricians alike. Front Matter ....Pages i-viii Epidemiology and Etiology of Ovarian Cancer (Hiroyuki Nomura, Naomi Iwasa, Tomoko Yoshihama, Yoshiko Nanki, Daisuke Aoki)....Pages 1-13 Hereditary Ovarian Cancer (Masayuki Sekine, Takayuki Enomoto)....Pages 15-35 Morphological and Molecular Pathogenesis of Epithelial Ovarian Tumors (Hironori Tashiro, Yuko Imamura, Takeshi Motohara, Isao Sakaguchi, Hidetaka Katabuchi)....Pages 37-56 Screening and Prevention of Ovarian Cancer (Hiroshi Kobayashi)....Pages 57-81 Pathology of Epithelial Ovarian Tumors (Hiroyuki Yanai)....Pages 83-113 Pathology of Non-epithelial Ovarian Tumors (Masaharu Fukunaga)....Pages 115-141 Ovarian Cancer Genome and Molecular Experimental Sciences (Noriomi Matsumura, Ikuo Konishi)....Pages 143-154 Strategies for the Management of Epithelial Ovarian Cancer (Nozomu Yanaihara, Aikou Okamoto)....Pages 155-164 Strategies for the Management of Epithelial Ovarian Borderline Tumors (Kimio Ushijima)....Pages 165-171 Strategies for the Management of Non-epithelial Ovarian Tumors (Satoru Kyo)....Pages 173-190 Primary Surgical Treatment of Epithelial Ovarian Cancer (Mikio Mikami)....Pages 191-205 Primary Chemotherapy and Targeted Molecular Therapy of Epithelial Ovarian Cancer (Satoru Nagase, Tsuyoshi Ohta, Manabu Seino)....Pages 207-224 Immunology and Immunotherapy in Ovarian Cancer (Masaki Mandai, Junzo Hamanishi, Kaoru Abiko, Noriomi Matsumura, Tsukasa Baba, Ikuo Konishi)....Pages 225-242 Treatment of Recurrent Epithelial Ovarian Cancer (Shintaro Yanazume, Hiroaki Kobayashi)....Pages 243-265 Management of Ovarian Cancer in Adolescents and Young Adults (Norihito Yoshioka, Nao Suzuki)....Pages 267-279 Management of Ovarian Cancer in the Elderly Population (Masanori Kaneuchi, Hideaki Masuzaki)....Pages 281-303 Palliative Medicine in the Management of Ovarian Cancer (Masaki Fujimura)....Pages 305-314 "This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades, making it essential to pursue multidisciplinary treatment and apply novel techniques such as neoadjuvant chemotherapy in daily clinical practice. The primary clinical task is the effective treatment of recurrent ovarian cancer with early palliative medicine. Fertility-sparing surgery may also be pursued depending on histologic subtypes, stage, extent of disease, and preexisting ovarian reserve with the concept of oncofertility. On the basis of the considerations described above, each expert author elucidates the science of ovarian cancer in detail, thus providing a collection that will benefit young medical oncologists and seasoned gynecologists and obstetricians alike." -- Prové de l'editor