مرزهای تحقیق بالینی دارو - عوامل ضد سرطان: جلد ۷

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The seventh volume of the book features reviews on these topics: · Essential oils and monoterpenes as potential anti-cancer agents · Drug delivery systems and emerging immunotherapeutic strategies for the treatment of glioblastoma · CTDNA in solid tumors · Cholesterol treatments (including Pitavastatin) and their potential in cancer treatment Cover Title Copyright End User License Agreement Contents Preface List of Contributors Essential Oils and Monoterpenes as Potential Anti-Cancer Agents Julia Pérez-Ramos1, Nimsi Campos-Xolalpa1, Roberto Serrano1, Cuauhtemoc Pérez1 and Salud Pérez1,* INTRODUCTION DISCUSSION CANCER CELL LINE ABBREVIATIONS CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES A Glance at Drug Delivery Systems and Emerging Immunotherapeutic Strategies for the Treatment of Glioblastoma Greta Varchi1, Marzia Bruna Gariboldi2 and Claudia Ferroni2,* INTRODUCTION GLIOBLASTOMA STANDARD TREATMENT IMMUNOTHERAPY IN GBM Immunomodulator Therapy Passive Immunotherapy: Current State of Immune Checkpoint Inhibitors and Adoptive Therapy Immune Checkpoint Inhibitors (ICIs) Adoptive Cell Therapy Current Vaccine Trials in GBM Dendritic Cell Vaccine Peptide Vaccine Heat Shock Protein-based Vaccine Combination Strategies Checkpoint Inhibitors Combination Therapy Different Combination Strategies Targeting Other Immunotherapeutic Pathways DRUG DELIVERY-BASED APPROACH Pre-clinical Studies on Brain-targeted Nanocarriers Clinical Studies on Brain-targeted Nanocarriers CONCLUSION AND FUTURE ADVANCES CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES ctDNA in Solid Tumors: Role in Diagnosis, Prognosis and Treatment Sevgi Akaydin1,*, Ece Miser Salihoğlu1 and Dolunay Merve Fakioğlu1 INTRODUCTION BREAST CANCER ctDNA as Diagnostic Biomarker of Breast Cancer ctDNA as Prognostic Biomarker of Breast Cancer ctDNA in the Targeted Therapy of Breast Cancer NON-SMALL CELL LUNG CANCER ctDNA as Diagnostic Biomarker of Non-Small Cell Lung Cancer ctDNA as Prognostic Biomarker of Non-Small Cell Lung Cancer ctDNA in the Targeted Therapy of Non-Small Cell Lung Cancer COLORECTAL CANCER Epigenetic Markers as a Diagnostic Biomarker in Colorectal Cancer ctDNA as a Diagnostic Biomarker in Colorectal Cancer ctDNA as Prognostic Biomarker in Colorectal Cancer Predictive ctDNA Markers in Colorectal Cancer PROSTATE CANCER ctDNA as Diagnostic Biomarker in Prostate Cancer ctDNA as Prognostic Biomarker in Prostate Cancer Predictive ctDNA Markers in Prostate Cancer OTHER TUMORS Gastrointestinal Stromal Tumors Head and Neck Cancer Squamous Cell Carcinoma Ovarian Cancer CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Pitavastatin and Cancer: Current and Future Prospects Saeb Aliwaini1,* INTRODUCTION PITAVASTATIN: THE CHEMICAL COMPOUND ANTI-CANCER PROPERTIES OF PITAVASTATIN Antitumor Effects of Pitavastatin In Vitro Anti-proliferative Effect of Pitavastatin Induction of Cell Cycle Arrest Apoptosis Activation Activation of Autophagy Anti-migration Effect Anti-inflammatory Effect Antitumor Effects of Pitavastatin In Vivo Chemical Carcinogenesis Studies Tumor Xenograft Studies PITAVASTATIN TARGETS CELLULAR PATHWAYS LIMITATIONS CONCLUSION AND FUTURE PERSPECTIVE CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Cholesterol: A Potential Target for Intervention in Anti-Cancer Therapy Nimai Chand Chandra1,*, Amar Preet Kaur2,#, Ayantika Talukdar3,#, Nimisha Saxena4,# and Shrimanjunath Sankanagoudar5,# INTRODUCTION POLYCYCLIC HYDROCARBONS Potential Carcinogenic Effect Polycyclic Cholesterol: A Perspective on Cell Proliferation and Carcinogenicity TRANSMEMBRANE CHOLESTEROL TRANSPORTERS Plasma Membrane Transporter: LDLR Mitochondrial Membrane Transporter: StAR and PBR Nuclear Membrane Transporter: PBR INTER-CORRELATION BETWEEN CHOLESTEROL TRANSPORTERS AND CELL PROLIFERATION INTRACELLULAR CHOLESTEROL, CELL CYCLE ACTIVITY AND CELL PROLIFERATION CHOLESTEROL: A STEER TO CELL CYCLE ACTIVITY AND CELL PROLIFERATION CHOLESTEROL HOMEOSTASIS IN CANCER TUMOUR CELLS Cholesterol Homeostasis in Leukemia Cholesterol Homeostasis in Prostate Carcinoma Cholesterol Homeostasis in Breast Carcinoma REPROGRAMMED CHOLESTEROL METABOLISM IN CANCER CELLS IMMUNE CELL SUPPRESSION BY CARCINOGEN AND CARCINOMA Does Carcinogen Target Cholesterol to Abrogate Immune Cells? Effect of Carcinogen on T-Cell Immunity and the Role of Cholesterol Effect of Carcinogen on B-cell Immunity and the Role of Cholesterol BIPHASIC ROLE OF CHOLESTEROL IN PROMOTING TUMOR CELL PROLIFERATION AND TUMOR DEFENSIVE IMMUNE CELL DEATH ANTI-CANCER ANTI-CHOLESTEROL TARGET ANTI-CANCER DRUG TARGETS: PREVENTION AGAINST INIMICAL DOUBLE-EDGED REPROGRAMMED CHOLESTEROL HOMEOSTASIS SUMMARY AND CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Subject Index Back Cover