Frontiers in Celiac Disease (Pediatric and Adolescent Medicine, Vol. 12)

Few other fields in human biology have experienced such a tremendous progress as celiac disease has during the past few years. The contributors to 'Frontiers in Celiac Disease' are world-renowned opinion leaders who made these advances possible. Their expertise has been assembled here to provide a comprehensive overview of the current knowledge of the epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of celiac disease. In addition, the stage is set for innovative strategies for preventive interventions and treatment alternatives to a gluten-free diet. A valuable reference for basic and translational scientists, this book also serves as a practical resource to healthcare professionals, including general practitioners, subspecialists, dieticians, nutritionists, and nurses and nurse practitioners. Students from different disciplines will find this book a helpful guide to expand and deepen their knowledge of celiac disease. Historical perspective of celiac disease / Guandalini, S. Natural history of celiac disease / Kaukinen, K.; Collin, P.; Miki, M. The changing clinical presentation of celiac disease / Lebenthal, E.; Shteyer, E.; Branski, D. The global village of celiac disease / Catassi, C.; Yachha, S.K. HLA and non-HLA genes in celiac disease / Zhernakova, A.; Wijmenga, C. Twins and family contribution to genetics of celiac disease / Greco, L.; Stazi, M.A.; Clerget-Darpoux, F. Biochemistry and biological properties of gliadin peptides / Barone, M.V.; Auricchio, S. Innate immunity and celiac disease / Meresse, B. ... [et al.] Celiac disease: across the threshold of tolerance / Koning, F. The role of the intestinal barrier function in the pathogenesis of celiac disease / Fasano, A.; Schulzke, J.D. Diagnosis of coeliac disease: open questions / Auricchio, R.; Troncone, R. Current guidelines for the diagnosis and treatment of celiac disease / Caicedo, R.A.; Hill, I.D. Current therapy / Stern, M. Update on the management of refractory coeliac disease / Al-toma, A.; Verbeek, W.H.M.; Mulder, C.J.J. The national institutes of health consensus conference report / Cohen, M.B.; Barnard, J.A. Beyond coeliac disease toxicity: detoxified and non-toxic grains / Gilissen, J.; van der Meer, I.M.; Smulders, M.J.M. Oral glutenase therapy for celiac sprue / Ehren, A.; Khosla, C. Inhibitors of intestinal barrier dysfunction / Paterson, B.M.; Turner, J. Development of a vaccine for celiac disease / Anderson, R.P. Regulatory T cells in the coeliac intestinal mucosa: a new perspective for treatment? / Gianfrani, C. ... [et al.] Strategies for prevention of celiac disease / Hogen Esch, C.E. ... [et al.] Towards preventing celiac disease: an epidemiological approach / Ivarsson, A. ... [et al.] Animal models of celiac disease / Marietta, E.V. ... [et al.]. cover......Page 1 Contents-Preface.pdf......Page 2 1 Historical Perspective of Celiac Disease......Page 10 2 Natural History of Celiac Disease......Page 21 3 The Changing Clinical Presentation of Celiac Disease......Page 27 4 The Global Village of Celiac Disease......Page 32 5 HLA and Non-HLA Genes in Celiac Disease......Page 41 6 Twins and Family Contribution to Genetics of Celiac Disease......Page 55 7 Biochemistry and Biological Properties of Gliadin Peptides......Page 66 8 Innate Immunity and Celiac Disease......Page 75 9 Celiac Diseas Across the Threshold of Tolerance......Page 91 10 The Role of the Intestinal Barrier Function in the Pathogenesis of Celiac Disease......Page 98 11 Diagnosis of Coeliac Disease......Page 108 12 Current Guidelines for the Diagnosis and Treatment of Celiac Disease......Page 116 13 Current Therapy......Page 123 14 Update on the Management of Refractory Coeliac Disease......Page 132 15 The National Institutes of Health Consensus Conference Report......Page 142 16 Beyond Coeliac Disease Toxicity......Page 148 17 Oral Glutenase Therapy for Celiac Sprue......Page 157 18 Inhibitors of Intestinal Barrier Dysfunction......Page 166 19 Development of a Vaccine for Celiac Disease......Page 181 20 Regulatory T Cells in the Coeliac Intestinal Mucosa......Page 190 21 Strategies for Prevention of Celiac Disease......Page 197 22 Towards Preventing Celiac Disease – An Epidemiological Approach......Page 207 23 Animal Models of Celiac Disease......Page 219 Author Index......Page 226 Subject Index......Page 227