Free radicals in biology. Vol. 4. Ed. by William A. Pryor

Free Radicals in Biology, Volume IV reviews diverse topics in free radical biology and covers topics ranging from radiation biology to lipid peroxidation, radical-mediated liver pathology, and chemical carcinogenesis. Radical mechanisms in prostaglandin biochemistry are also discussed, along with the use of electron spin resonance and spin trap methods to probe mechanisms of radical reactions in biological systems. Comprised of 10 chapters, this volume begins with an overview of the mechanisms of lipid peroxidation, focusing on the chemistry of fluorescent products from in vivo lipid peroxidation; the production of pentane in the expired breath of animals exposed to oxidative threats; and the chemistry of the enzyme glutathione peroxidase. The next chapter is devoted to the kinetic aspects of lipid peroxidation and the multiple ways in which autoxidants can react. The reader is then introduced to the mechanisms of hepatoxicity by synthetic chemicals present in the environment, together with direct mechanisms of radiation damage to nucleic acids. Subsequent chapters deal with spin trapping in biological systems; the role of free radicals in arylamine carcinogenesis and their influence on the structure and reactivity of melanins; and the involvement of vitamin? and lipid antioxidants in free-radical-initiated reactions. This book will be of value to chemists, biologists, and physicians. Content: Contributors , Page ii Front Matter , Page iii Copyright , Page iv List of Contributors , Pages xi-xii General Preface , Pages xiii-xiv , William A. Pryor Preface to Volume IV , Pages xv-xvii , William A. Pryor Contents of Other Volumes , Pages xix-xxi CHAPTER 1 - Measurement of and Protection from in Vivo Lipid Peroxidation , Pages 1-47 , Al L. Tappel CHAPTER 2 - Free-Radical Damage in Liver , Pages 49-94 , Edward S. Reynolds, Mary Treinen Moslen CHAPTER 3 - Free-Radical Damage of Nucleic Acids and Their Components: The Direct Absorption of Energy , Pages 95-114 , L.S. Myers Jr. CHAPTER 4 - A Critical Review of Spin Trapping in Biological Systems , Pages 115-154 , Edward G. Janzen CHAPTER 5 - Production of Radicals from Enzyme Systems and the Use of Spin Traps , Pages 155-186 , Paul B. McCay, Toshikazu Noguchi, Kuo-Lan Fong, Edward K. Lai, J. Lee Poyer CHAPTER 6 - Free Radicals in Arylamine Carcinogenesis , Pages 187-208 , Robert A. Floyd CHAPTER 7 - Structure and Reactivity of Melanins: Influence of Free Radicals and Metal Ions , Pages 209-259 , R.C. Sealy, C.C. Felix, J.S. Hyde, H.M. Swartz CHAPTER 8 - Prostaglandin Endoperoxides , Pages 261-294 , Ned A. Porter CHAPTER 9 - Vitamin E and Lipid Antioxidants in Free-Radical-Initiated Reactions , Pages 295-319 , Lloyd A. Witting CHAPTER 10 - Stable Radiation-Induced Paramagnetic Entities in Tissue Mineral and Their Use in Calcified Tissue Research , Pages 321-344 , Kazimierz Ostrowski, Anna Dziedzic-Goctawska, Wactaw Stachowicz Subject Index , Pages 345-348