Free Energy Transduction in Biology : The Steady-State Kinetic and Thermodynamic Formalism

Free Energy Transduction in Biology: The Steady-State Kinetic and Thermodynamic Formalism focuses on the steady-state kinetic and thermodynamic formalism related to free energy transduction. As the word ""formalism"" implies, the discussion concerns general principles and methods and not details of proposed mechanisms in the various special cases. Organized into seven chapters, this book first describes the diagram method, which is the main analytical tool in the study of discrete state, cycling system. The next chapter describes the essential topic of cycles and cycle fluxes. Some chapters discuss the more important bioenergetic principles that emerge from the diagram approach. This book is also concerned with somewhat more specialized aspects of the subject (stochastics and fluctuations) and interacting subsystems and multienzyme complexes, including oxidative phosphorylation. Content: Front Matter , Page iii Copyright , Page iv Dedication , Page v Preface , Pages xi-xii Chapter 1 - The Diagram Method: States , Pages 1-16 Chapter 2 - The Diagram Method: Cycles , Pages 17-32 Chapter 3 - Fluxes and Forces , Pages 33-56 Chapter 4 - Free Energy Levels of Macromolecular States , Pages 57-102 Chapter 5 - Muscle Contraction , Pages 103-129 Chapter 6 - Stochastics and Fluctuations at Cycle and State Levels , Pages 130-155 Chapter 7 - Interacting Subsystems and Multienzyme Complexes , Pages 156-191 Appendix 1 - “Reduction” of a Diagram , Pages 193-200 Appendix 2 - Diagram Solution for the N i ∞ Flux Diagrams , Pages 201-205 Appendix 3 - Charged Ligand and Membrane Potential , Pages 206-210 Appendix 4 - Some Properties of Single-Cycle Diagrams , Pages 211-212 Appendix 5 - Light Absorbing (and Emitting) Systems , Pages 213-221 Appendix 6 - Basic and Gross Free Energy Levels in a Simple Special Case , Pages 222-226 Index , Pages 227-229