Forensic Medicine and Human Cell Research: New Perspective and Bioethics (Current Human Cell Research and Applications)

This volume reviews the application of biochemical and molecular pathologies, which are based on conventional pathomorphology, toxicology, and DNA analysis technologies, not only to autopsies but also to the field of clinical medicine in general. The systematic and integrated use of biochemical, immmunohistochemical, and molecular pathology, toxicology, DNA analysis, and cell culture investigations reinforces the pathophysiological diagnostic criteria in a forensic autopsy for clinical diagnosis. The use of these technologies can help to determine the cause and process of death and characterize the functional pathophysiological changes in the body that occur during the death process. Recently, the systematization of the latest supplemental tests, diagnostic methods, and quality control has allowed us to conduct comprehensive data collection and analysis for a range of diseases. This book presents the latest findings on the pathology of a broad range of human diseases, based on data concerning postmortem biochemistry and molecular biology collected from approximately 1000 people. Further, it puts forward a code of ethics for undertaking pathophysiological research and describes research techniques for uncovering pathophysiological mechanisms. As such, it offers a unique resource for researchers in the field of forensic medicine and pathology, and for clinicians. ​ Front Matter ....Pages i-x Biomarkers for “Cause of Death” (Takako Sato, Koichi Suzuki)....Pages 1-11 Forensic Biochemistry (Tomoya Ikeda, Naoto Tani, Tomomi Michiue, Takaki Ishikawa)....Pages 13-27 Application of Molecular Pathology in Forensic Medical Diagnosis (Naoto Tani, Tomoya Ikeda, Shigeki Oritani, Tomomi Michiue, Takaki Ishikawa)....Pages 29-43 Alcohol and Pathophysiology (Risa Kudo, Katsuya Yuui, Katsuhiko Hatake)....Pages 45-64 Forensic Toxicology of Stimulants and Psychotropic Drugs (Minori Nishiguchi, Hajime Nishio)....Pages 65-81 Metabolic Autopsy and Molecular Autopsy in Sudden Unexpected Death in Infancy (Takuma Yamamoto, Hajime Nishio)....Pages 83-103 Genetics in Forensic Science (Aya Matsusue, Shin-ichi Kubo)....Pages 105-121 Animal Experiments in Forensic Science (Dong Zhao)....Pages 123-146 Cultured Cell Experimental Models (Naoto Tani, Tomoya Ikeda, Shigeki Oritani, Tomomi Michiue, Takaki Ishikawa)....Pages 147-157 Future Perspectives (Tomoya Ikeda, Naoto Tani, Takaki Ishikawa)....Pages 159-164