Focus on Gynecologic Malignancies (Energy Balance and Cancer Book 13)

Gynecologic malignancies, especially endometrial and ovarian cancers are among the most important and most severely affected by obesity. This volume of Energy Balance and Cancer, written by the world’s leading experts in this field, is arranged to provide a transdisciplinary assessment of the pertinent issues, results of relevant research on mechanisms, and control, strategies for dealing with affected patients and improving outcomes and future research needs. The volume comprehensively covers the epidemiology linking obesity to endometrial and ovarian cancer as well as the public awareness of this critical problem. Subsequent chapters explain biologic aspects of linkages between energy balance and gynecologic malignancies. The volume further outlines strategies to disrupt the linkage between obesity and gynecologic malignancies and concludes with a series of chapters focused on management strategies for obese patients with gynecologic malignancies. This volume provides a valuable resource for all physicians, scientists and other transdisciplinary investigators and practitioners interested and involved in energy balance and cancer. It should be a particularly useful guide to optimize outcomes for all practitioners dealing with patients with gynecologic malignancies challenged by energy balance issues. Moreover, it should serve as a useful guide to students and investigators interested in conducting further research on defining and disrupting the important linkage between energy balance and gynecologic malignancies. Front Matter ....Pages i-xiii Epidemiologic Evidence for the Obesity-Endometrial Cancer Relationship (Melissa A. Merritt, Marc J. Gunter)....Pages 1-19 Epidemiologic Relationship Between Obesity and Ovarian Cancer (Carmen Jochem, Inga Schlecht, Michael Leitzmann)....Pages 21-30 Public Knowledge of Obesity and Gynecologic Cancer Risk (Shannon Armbruster, Pamela T. Soliman)....Pages 31-40 Role of Estrogen and Progesterone in Obesity Associated Gynecologic Cancers (Louise A. Brinton, Britton Trabert)....Pages 41-61 Obesity and Endometrial Cancer Precursors (Jaclyn Watkins)....Pages 63-71 Obesity, Adipokines, and Gynecologic Cancer (Elizabeth V. Connor, Ofer Reizes, Caner Saygin)....Pages 73-102 Adipose Derived Stromal Cells in Gynecologic Cancers (Aparna Mitra, Ann H. Klopp)....Pages 103-112 Obesity and Endometrial Cancer: Mouse Models for Preclinical Prevention Studies (Rosemarie E. Schmandt, Katherine A. Naff)....Pages 113-135 Lifestyle Interventions to Reduce the Risk of Obesity-Associated Gynecologic Malignancies: A Focus on Endometrial Cancer (Faina Linkov, Sharon L. Goughnour, Shalkar Adambekov, Robert P. Edwards, Nicole Donnellan, Dana H. Bovbjerg)....Pages 137-165 Hormonal and Metabolic Strategies to Overcome Insulin Resistance and Prevent Endometrial Cancer (Sarah Kitson, Emma J. Crosbie)....Pages 167-188 Management of Endometrial Cancer Precursors in Obese Women (Joseph A. Dottino, Karen H. Lu, Melinda S. Yates)....Pages 189-212 Exercise and Lifestyle Interventions in Gynecologic Cancer Survivors (Nora L. Nock)....Pages 213-222 Physical Activity as a Risk Factor for Ovarian Cancer (Tianyi Huang, Shelley S. Tworoger)....Pages 223-244 Impact of Obesity on Surgical Approaches to Gynecologic Malignancies (Amanika Kumar, William A. Cliby)....Pages 245-259 Obesity, Fertility Preservation and Gynecologic Cancers (Terri L. Woodard, Jessica Rubin)....Pages 261-278 Metformin as Adjuvant Therapy in Ovarian and Endometrial Cancers (Leslie H. Clark, Victoria L. Bae-Jump)....Pages 279-304 Back Matter ....Pages 305-312