Fluorine in Heterocyclic Chemistry in 2 Vol. v. 1 - 5-Membered Heterocycles and Macrocycles

Nenajdenko Valentine (ed.) Fluorine in Heterocyclic Chemistry in 2 Vol. v. 1 - 5-Membered Heterocycles and Macrocycles 2014 [pdf 682sc 681c. 54.86mb] This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology. Front Matter....Pages i-ix Tactical Applications of Fluorine in Drug Design and Development....Pages 1-54 Chemistry of Fluorinated Pyrroles....Pages 55-115 Chemistry of Fluorinated Indoles....Pages 117-156 Fluorinated Indolizines....Pages 157-180 Fluorinated Furans and Benzofurans....Pages 181-231 Fluorinated Thiophenes and Their Analogues....Pages 233-277 Fluorinated Pyrazoles and Indazoles....Pages 279-321 Fluorinated Imidazoles and Benzimidazoles....Pages 323-367 Chemistry of Fluorinated Oxadiazoles and Thiadiazoles....Pages 369-417 Fluorinated Oxazoles, Thiazoles and Selenazoles....Pages 419-458 Fluorinated Triazoles and Tetrazoles....Pages 459-513 1,2-Bis(Hetaryl)Perfluorocyclopentenes as Unique Thermally Irreversible Photochromes. Synthesis and Structural Singularities....Pages 515-553 Chemistry of α-Fluorinated Ethers- and Thioethers-Containing Heterocycles....Pages 555-587 Fluorinated Porphyrins and Corroles: Synthesis, Electrochemistry, and Applications....Pages 589-620 Fluorinated Phthalocyanines and Their Analogues....Pages 621-681