Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies (Archives of Virology. Supplementa Book 20)

The filoviruses (Lake Victoria marburgvirus and ebolaviruses) are etiological agents of severe hemorrhagic fevers with extraordinary high case-fatality rates for humans, chimpanzees, gorillas, and probably other animals. Many institutions and experts consider them as potential threats to humanity because they could be used as biological weapons. This book summarizes in detail the contemporary knowledge of filoviruses and diseases they cause. Almost the entirety of the open literature on filoviruses, covering all major scientific and clinical fields, is referenced and summarized in this text, including most of the conference abstracts, book chapters, dissertations, government reports, patents, theses, and journal publications in many languages. The book will provide a robust source of knowledge for filovirologists, virologists and scientists in general, clinicians, students, journalists, and biodefense professionals.

The filoviruses (Lake Victoria marburgvirus and the ebolaviruses) are etiological agents of severe hemorrhagic fevers with extraordinary high case-fatality rates for humans, chimpanzees, gorillas, and probably other animals.
This review summarizes in detail the contemporary knowledge of filoviruses and the diseases they cause. The entirety of the open literature on filoviruses, covering all major scientific and clinical fields, is referenced and summarized in this text, including most of the conference abstracts, book chapters, dissertations, government reports, patents, theses, and journal publications in many languages. In total, almost 4,500 references (~3,350 citations and ~1,150 subcitations , such as abstracts, reprints, or translations) are provided on a CD-ROM as an accompanying reference source for the book – roughly three times the number of references that can be recovered using PubMed searches (~1,450). For ease of retrieval by the reader, all references are cited with original titles in the original spelling, first author names, full journal titles, and issue numbers where possible. The text of this book and the accompanying reference resource will be updated in the future, and thus will provide a robust source of information for filovirologists, other virologists and scientists in general, clinicians, students, journalists, and biodefense professionals.

Front Matter....Pages 1-12 Introduction....Pages 13-58 History of filoviral disease outbreaks....Pages 59-97 Clinical presentation of filoviral disease....Pages 99-120 Filoviral disease pathology....Pages 121-141 Geographic distribution of filoviruses: serological surveys....Pages 143-152 Ecology of filoviruses: search for reservoirs....Pages 153-170 Cultivation of filoviruses....Pages 171-173 Molecular characteristics of filoviruses....Pages 175-264 Laboratory diagnosis of filoviral disease....Pages 265-277 Outbreak containment....Pages 279-296 Inactivation of filoviruses and disinfection protocols....Pages 297-299 Vaccine development....Pages 301-334 Treatment of filoviral disease....Pages 335-346 Appendix: Members of the Filoviridae Study Group, ICTV....Pages 347-348 Back Matter....Pages 349-413 Introduction History of filoviral diseases outbreaks Clinical presentation of filoviral disease Filoviral disease pathology Geographic distribution of filoviruses : serological surveys Ecology of filoviruses : search for reservoirs Cultivation of filoviruses Molecular characteristics of filoviruses Laboratory diagnosis of filoviral disease Outbreak containment Inactivation of filoviruses and disinfection protocols Vaccine development Treatment of filoviral disease This is the first comprehensive review of the world literature on filovirus research and provides the most extensive bibliography of the subject yet published. There is special emphasis on foreign literature that has never been summarized. Every aspect of filovirus research, including their history, epidemiology, clinical picture, pathology, molecular biology, and political aspects are reviewed in detail.