Fibrinogen. Proceedings/ Workshop on Fibrinogen. Vol. 4, Fibrin formation and Fibrinolysis ; April, 2-3, 1985, London, England

This volume contains the proceedings of a workshop entitled "Fibrinogen, fibrin formation and fibrinolysis" that was held on April 2-3 1985 at Queen Elizabeth College, London. The workshop was attended by approximately 100 basic and clinical researchers and its aim was to encourage informal interchange of ideas about the fibrinogen molecule, its involvement in normal haemostasis and in pathology. Previous workshops have been held at Martinsried, Leiden and Stockholm. Their proceedings have been published as earlier volumes in a series of which this volume constitutes the 4th: Preface Contributors Contents I. Synthesis And Assembly A scheme for the intracellular assembly of human fibrinogen Evidence that platelet and plasma fibrinogen have the same A-alpha chain gene product Fibrinopeptide A and the phosphorylation of fibrinogen II. Structure and Function Size and shape of the fibrinogen molecule: crystalline forms of native and modified human fibrinogen The C-terminal polymerisation domain of fibrinogen γ- Chain Crosslinking Of Fibrin At Dd-Trans Contact Soluble fibrin contains fibrin polymers of different molecular weight. Ultracentrifugation studies at 37°C Relationship of final thickness of fibrin fibers to maximal rate of assembly and to fibrinopeptide B release III. Congenital Variants Fibrinogen New York 1: The structural, functional, and genetic defects and an hypothesis of the role of fibrin in the regulation of coagulation and fibrinolysis Fibrinogen Pontoise - a genetically abnormal fibrinogen with defective fibrin polymerisation but normal fibrinopeptide release Fibrinogen Milano I: Abnormal fibrin polymerization related to a carboxy-terrainal defect of the γ-chain (γ-330 Asp Val) Fibrinogen "Bergamo I" (Λα 16 Arg - Cys): Alternative methods for structure elucidation Screening small plasma samples by HPLC for abnormalities of fibrinopeptide release Iv. Fibrin(ogen) And Fibrinolysis On the role of fibrin in the fibrinolytic system Isolation and characterisation of plasmic degradation products of fibrinogen by high-performance liquid chromatography The acceleration of tissue-type plasminogen activator (t-PA)-mediated activation of plasminogen by fibrinogen cyanogen bromide fragments is species specific Role of fibrin polymerization in fibrinolysis: Comparison between polymerisable and unpolymerisable fibrins in the potentiating effect of plasminogen activation by tissue-type plasminogen activator (tpA) Role of fibrin and its degradation products in the activation of plasminogen by streptokinase and urokinase V. Interactions With Cells The role of fibrinogen in platelet aggregation Platelet-associated fibrinogen: Conformational change of fibrinogen induced by its adsorption to platelet-surface Migration of cultured endothelial cells in response to fibrinogen Characteristics of the interactions of fibrinogen and soluble fibrin with cultured endothelial cells Mechanism of fibrin-induced disorganisation of cultured human endothelial cells The fibrinogen: red cell interaction and its influence on blood rheology Haemorheologic effects of plasmin and thrombininduced fibrinogen derivatives: An in vitro study Binding of human fibrinogen to streptococci and its role in streptococcal pathogenicity VI. Assays To Fibrin(ogen) Fragments And Their Use Discrimination between fibrin and fibrinogen by a monoclonal antibody against a synthetic hexapeptide representing the amino-terminus of the alpha-chain of fibrin A new enzyme immunoassay of fibrin(ogen) degradation products in plasma using a monoclonal antibody Fibrin(ogen) degradation products. Determination using a monoclonal anti D neo antibody. Advantages in clinical investigation A monoclonal antibody, specific for human fibrinogen and fibrinopeptide A-containing fragments. Its application in an enzyme-immunoassay for fibrinogen degradation products, suitable for use in plasma A monoclonal antibody against the CNBr-peptide F-CB3 of the Aα-chain of human fibrinogen Clinical aspects of fibrin formation and fibrinolysis measured with monoclonal antibodies against D-dimer Fibrinogen derivatives in acute stroke VII. Fibrin(ogen) And Disease Pathology Triggering of the extrinsic blood coagulation system Extravascular fibrin formation and fibrinolysis in a model of inflammation accompanying cellular hypersensitivity Extra-vascular fibrin deposition in cellular hypersensitivity - the role of T lymphocyte-macrophage interactions Fibrinolytic studies in disorders of connective tissue Soluble fibrin/fibrinogen related antigen in human intima in relation to atherogenesis Fibrinogen as a possible risk factor for IHD in the Caerphilly study VIII. Appendix: Data On Fibrinogen Fibrinogen amino acid sequences Author Index Subject Index

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