Fibrinogen. Proceedings/ Workshop on Fibrinogen, [2], Structure, functional aspects, metabolism ; May 12–14, 1982, Leiden, The Netherlands

Das moderne Bibliotheks- und Informationswesen setzt sich mit vielfältigen Anforderungen auseinander und entwickelt sich ständig weiter. Die Reihe Bibliotheks- und Informationspraxis greift neue Themen und Fragestellungen auf und will mit Informationen und Erfahrungen aus der Praxis dazu beitragen, Betriebsabläufe und Dienstleistungen von Bibliotheken und vergleichbaren Einrichtungen optimal zu gestalten. Die Reihe richtet sich an alle, die in Bibliotheken oder auf anderen Gebieten der Informationsvermittlung tätig sind. Preface Contributors And Addresses Contents I. Physicochemical Aspects Hydrodynamic characterization of human fibrinogen Early plasmin digestion of fibrinogen: light scattering data Correlation of fibrinopeptide A release and light scattering during fibrinogen to fibrin transformation A kinetic approach to the polymerization of fibrin at high ionic strength Secondary Structure Of Fibrin II. Fibrinogen-Fibrin Conversion Synthetic peptide Gly-His-Arg-Pro activates fibrin monomers Fibrinopeptide characterization and kinetics of release in animal fibrinogens as analysed by highperformance liquid chromatography III. Interaction with Divalent Cations The topography of fibrinogen fragment D Calcium binding to fibrinogen investigated by rate of dialysis Calcium-binding sites and anticlotting properties of human fibrinogen and fibrin(ogen) fragments Binding of fibrinogen and degradation products to chelated zinc IV. Abnormal Fibrinogens Genetically abnormal fibrinogens - some current characterisation strategies Two-dimensional electrophoretic characterization (iso-dalt) of fibrinogen and fibrin subunit chains from four different genetic dysfibrinogen variants The molecular abnormality of fibrinogen Manchester Functional characterisation and protein chemical analysis of two new cases of dysfibrinogenemia, London III & IV Genetically abnormal fibrinogens releasing abnormal fibrinopeptides as characterised by high-performance liquid chromatography Sialic acid and sialyltransferase in the pathogenesis of acquired dysfibrinogenaemia V. Fibrinogen Derived Products in vitro and in vivo Comparative studies on F-CB3 related antigen, fibrinogen degradation products, soluble fibrin monomer complexes and fibrinogen in patients with renal carcinoma Characterization of crosslinked high molecular weight fibrin derivatives from in vitro and in vivo (ascitic fluid) material Immunochemical differentiation of fibrinogen, fragment D or E, and cross-linked fibrin degradation products using monoclonal antibodies Purification and properties of early (X-like) and late (D-like) fibrinogen fragments, produced by leukocyte elastase Formation of fibrin degradation products from a non-anticoagulated whole blood clot VI. Biosynthesis and Clearance Changes of synthesis of fibrinogen polypeptide and albumin mRNAs in rat liver after turpentine injection and after partial hepatectomy or laparotomy Role of kidney in eliminating low molecular weight fibrinogen derivatives from the circulation Clearance of I 125 fibrinogen and I 131 soluble fibrin in normals and in fibrinaemic patients: a pilot study Clearance of homologous fibrin monomers and fibrin(ogen) degradation products in the rat VII. Other Physiological Aspects of Fibrinogen Evidence for Specific sites in fibrin(ogen) that stimulate tissue activator catalyzed plasminogen activation Vasoactive Peptides Released From The ßß-Chain On Degradation Of Human Fibrin(Ogen) By Plasmin Or Elastase Interactions between fibrin and fibronectin. No effect of fibronectin on the plasma solubility of fibrin monomers Interactions between fibronectin and soluble fibrin - no effect of fibrin monomers upon the formation of the heparin precipitable fraction of plasma Author Index Subject Index