Fibrin Sealant in Operative Medicine : Volume 6 General Surgery and Abdominal Surgery

Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage, and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation. The concept of using clotting substances from human blood for wound manage­ ment and to achieve hemostasis in bleeding parenchymatous organs can be traced to 1909, when Bergel [1] reported on the hemostatic effect of fibrin powder. In 1915, Grey [3] employed fibrin to control bleeding in neurosurgical operations of the brain. A year later, Harvey [4] used fibrin patches to stop bleeding from parenchy­ matous organs in general surgery. It took more than two decades for this ingenious idea to be rediscovered. In 1940, Young and Medawar [8] reported on experimental nerve anastomosis by sealing. Similarly, Tarlov and Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov improved the results obtained with clot anastomosing of nerves by avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2] reported on an initial series of eight cases in which fibrinogen and thrombin had been used successfully for anchoring skin grafts. Front Matter....Pages I-XVII Front Matter....Pages 1-1 The Importance of Fibrin in Wound Repair....Pages 3-12 Fibrin Sealant and Its Modes of Application....Pages 13-26 Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations....Pages 27-38 Lysis and Absorption of Fibrin Sealant (Tissucol/Tisseel)....Pages 39-50 Preliminary Results of a Randomized Controlled Study on the Risk of Hepatitis Transmission of a Two-Component Fibrin Sealant (Tissucol/Tisseel)....Pages 51-59 Front Matter....Pages 61-61 Clinical Experience with Fibrin Sealing in General and Thoracic Surgery....Pages 63-71 The Use of Infrared Sapphire Contact Coagulation and Fibrinogen Adhesive for Hemostasis After Partial Hepatectomy: A Comparative Study....Pages 72-84 Survey of Liver Regeneration Following Liver Resection by Application of Fibrin Sealant....Pages 85-90 Experience with the Use of Fibrin Sealant in Surgical Therapy of Liver Tumours....Pages 91-95 Splenic Salvage by the Use of Fibrin Tissue Adhesive....Pages 96-108 The Use of Fibrin Sealant in Organ Preserving and Transplantation Surgery of the Spleen in Children....Pages 109-115 Experimental Splenic Injury Treated with Fibrin Sealant....Pages 116-121 Fibrin Sealing of Parenchymal Organs in Pediatric Surgery....Pages 122-130 Use of Fibrin Sealant in Paediatric Surgery....Pages 131-139 The Use of Tissucol (Tisseel) in Pancreatic Surgery....Pages 140-144 Securing Pancreatodigestive Anastomoses with Fibrin Sealant....Pages 145-149 Experimental Fibrin and Cyanoacrylate Adhesion: A Comparative Investigation....Pages 150-151 Use of Fibrin Sealant (Tissucol/Tisseel) in Manual and Stapled Anastomoses....Pages 152-154 Colonic Anastomoses Protected with Fibrin Sealant (Tissucol/Tisseel)....Pages 155-158 Fibrin Adhesive in Colorectal Surgery....Pages 159-164 Front Matter....Pages 61-61 From Conventional Suturing to Sutureless Anastomoses in General Surgery....Pages 165-172 Endoscopic Therapy of Fistulae with Fibrin Tissue Sealant....Pages 173-179 Lymph Fistulae Following Lymph Node Dissections: Avoidance and Treatment by Use of Fibrin Sealing....Pages 180-183 Fibrin Sealant in Skin Necroses Induced by Cytostatic Drugs and in Superinfected Wounds....Pages 184-193 The Kinetics of Antibiotic Release from a Fibrin-Clotting System: An Animal Experiment....Pages 194-198 Haemostatic Effect of Fibrin Sealant in Patients with Congenital and Acquired Bleeding Disorders....Pages 199-202 Back Matter....Pages 203-204