Fetal Nutrition and Adult Disease : Programming of Chronic Disease through Fetal Exposure to Undernutrition. Frontiers in Nutritional Science Series, No. 2

This book aims to paint a broad picture of current understanding of fetal programming. The volume presents a range of epidemiological data demonstrating links between events in fetal life and the development of cardiovascular disease, non-insulin-dependent diabetes, obesity and disorders of the immune system. The book is divided into three parts: programming the fetus (Part I), programming human disease (part II) and biological basis of nutritional programming (part III). Part I sets out the basic principles of programming and considers the potential contribution of undernutrition and other insults during critical phases of embryonic and fetal development, to abnormal physiology and disease processes in later life. Part II provides the core of the book and shows how suggestive epidemiological evidence for an association between characteristics at birth and later disease is replicated in experimental model. This part presents data that question the birthweight-disease association, highlighting the importance of well-designed experimental studies. The final part of the book sets out current ideas about the interrelationships of maternal nutrition, placental function and fetal endocrinology and looks at how early nutrient-gene interactions may exert permanent influences on health and well-being of an individual. Available In Print Chapter: 1 (Page no: 1) Fetal programming of adult disease: an overview. Author(s): Langley-Evans, S. C. Chapter: 2 (Page no: 21) Nutritional basis for the fetal origins of adult disease. Author(s): Harding, J. Chapter: 3 (Page no: 55) Intrauterine hypoxaemia and cardiovascular development. Author(s): Giussani, D. A. Gardner, D. S. Chapter: 4 (Page no: 87) Epidemiology of the fetal origins of adult disease: cohort studies of birthweight and cardiovascular disease. Author(s): Rich-Edwards, J. Chapter: 5 (Page no: 105) Early-life origins of adult disease: is there really an association between birthweight and chronic disease risk? Author(s): Huxley, R. Chapter: 6 (Page no: 129) Experimental models of hypertension and cardiovascular disease. Author(s): Langley-Evans, S. C. Chapter: 7 (Page no: 157) Associations between fetal and infant growth and non-insulin-dependent diabetes. Author(s): Langley-Evans, S. C. Chapter: 8 (Page no: 171) Programming of diabetes: experimental models. Author(s): Reusens, B. Kalbe, L. Remacle, C. Chapter: 9 (Page no: 195) Birthweight and the development of overweight and obesity. Author(s): Stein, A. D. Chapter: 10 (Page no: 211) Maternal nutrition in pregnancy and adiposity in offspring. Author(s): Breier, B. H. Krechowec, S. O. Vickers, M. H. Chapter: 11 (Page no: 235) Renal disease and fetal undernutrition. Author(s): Woods, L. L. Chapter: 12 (Page no: 259) Perinatal determinants of atopic disease. Author(s): Demissie, K. Chung, K. D. Balasubramanian, B. A. Chapter: 13 (Page no: 311) Fetal programming of immune function. Author(s): McDade, T. W. Kuzawa, C. W. Chapter: 14 (Page no: 333) Programming in the pre-implantation embryo. Author(s): Young, L. E. Rees, W. D. Sinclair, K. D. Chapter: 15 (Page no: 353) Endocrine responses to fetal undernutrition: the growth hormone-insulin-like growth factor axis. Author(s): Symonds, M. E. Gardner, D. S. Pearce, S. Stephenson, T. Chapter: 16 (Page no: 381) Impact of intrauterine exposure to glucocorticoids upon fetal development and adult pathophysiology. Author(s): Drake, A. J. Seckl, J. R.

It's not just the lifestyle outside the womb, but the fetal environment has also been shown to affect risk of developing such problems as heart disease, stroke, obesity, diabetes, immune system disorders, and hypertension later in life. The in utero factors are termed fetal programming. (It's bad news for moms who already feel guilty; and it's important information for policymakers with power over access to prenatal care.) Langley-Evans (biochemistry, U. of Nottingham, UK) presents 16 contributions addressing various aspects of this hot topic, including principles, epidemiological data, and experimental findings. Coverage includes the biological basis of nutritional programming—programming in the pre-implantation embryo, endocrine responses to fetal undernutrition, and the impact of intrauterine exposure to glucocorticoids—as well as studies of links between birthweight and risk of cardiovascular or chronic disease, experimental models of programming, and renal disase and fetal undernutrition, among other topics. Distributed in the US by Oxford U. Press. Annotation ©2005 Book News, Inc., Portland, OR

Over the last decade epidemiological studies have suggested that the risk of coronary heart disease, stroke mortality and hypertension is, in part, related to the environment encountered during fetal life. In particular, maternal undernutrition during pregnancy has been highlighted as a causal factor in the long-term programming of disease risk.This book, which brings together the perspectives of leading researchers from Europe, the USA and Australasia, provides the reader with a detailed account of the evidence for and against the nutritional programming of human disease, and considers the biological basis of programming. The book addresses a topic of great current interest and consists of three sections: programming the fetus; programming human disease; and the biological basis of nutritional programming. Over the last decade, epidemiological studies have suggested that risk of coronary heart disease, stroke mortality and hypertension is, in part, related to the environment encountered during fetal life. In particular, maternal undernutrition during pregnancy has been highlighted as a causal factor in the long-term programming of disease risk. This book, which brings the perspectives of leading researchers from Europe, the U.S., and Austalasia, provides the reader with a detailed account of the evidence for and against the nutritional programming of human disease, and considers the biological basis of programming. The book addresses a topic of great current interest and consists of three sections: programming the fetus; programming human disease; and the biological basis of nutritional programming "This book, which brings together the perspectives of leading researchers from Europe, the USA and Australasia, provides the reader with a detailed account of the evidence for and against the nutritional programming of human disease, and considers the biological basis of programming. The book addresses a topic of great current interest and consists of three sections: programming the fetus; programming human disease; and the biological basis of nutritional programming. The book has been written for advanced students and researchers in human nutrition."--Jacket Provides the reader with a detailed account of the evidence for and against the nutritional programming of human disease. This book also covers programming the fetus, programming human disease, and the biological basis of nutritional programming This book is concerned with the fetal programming of disease, and examines a new paradigm for considering the aetiology of disease, based upon a range of evidence from human populations and experiments with animal models.