Feldman and Pike's Vitamin D: Volume Two: Disease and Therapeutics 5th Edition

Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D , Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. Contents List of contributors In memoriam Preface to the fifth edition List of abbreviations Relevant lab values in adults and children 51. Defining thresholds for vitamin D I: scientific rationale for serum 25-hydroxyvitamin D cutoffs of 25 and 50 nmol/L • Andrea L. Darling and Susan A. Lanham-New 52. Defining thresholds for vitamin D II • Reinhold Vieth 53. Methods of evaluating population studies of vitamin D: strengths and weaknesses • Edward Giovannucci 54. Worldwide vitamin D status • Natasja van Schoor, Renate de Jongh and Paul Lips 55. Vitamin D in food—Compounds, stability, sources • Jette Jakobsen and Marie Bagge Jensen 56. Determinants of vitamin D levels from sun exposure: a global perspective • William B. Grant, Harjit P. Bhattoa and Pawel Pludowski 57. Vitamin D supplement use as a public health strategy to augment diet and sustain population adequacy • Susan J. Whiting and Mona S. Calvo 58. Vitamin D and food fortification • Kevin D. Cashman and Mairead Kiely 59. Bariatric surgery, vitamin D, and bone loss • Tiffany Y. Kim and Anne L. Schafer 60. Genetic determinants of 25-hydroxy vitamin D concentrations • Elina Hyppönen, Ang Zhou and Karani S. Vimaleswaran 61. Effect of vitamin D on health and disease: evidence from Mendelian randomization • Katerina Trajanoska, Fernando Rivadeneira, J. Brent Richards and Despoina Manousaki 62. Growth plate histology, bone histomorphometry, and radiologic features of nutritional rickets and osteomalacia • Suma Uday and Wolfgang Högler 63. Vitamin D deficiency and nutritional rickets in infants and children • John M. Pettifor, Kebashni Thandrayen and Tom D. Thacher 64. Clinical disorders of phosphate homeostasis • Eva S. Liu and Harald Jüppner 65. The hypocalcemic disorders • Nadia Merchant and Rachel I. Gafni 66. Vitamin D hydroxylation—deficient rickets, type 1A • Francis H. Glorieux and René St-Arnaud 67. The role of genetic variation in CYP2R1, the principal vitamin D 25-hydroxylase, and CYP3A4 in vitamin D homeostasis • Jeffrey D. Roizen and Michael A. Levine 68. Hereditary 1,25-dihydroxy vitamin D resistant rickets (VDDR-2A) • Peter J. Malloy, Dov Tiosano and David Feldman 69. Infantile hypercalcemia and CYP24A1 mutations • Filomena Cetani, Daniele Cappellani, Alessandro Brancatella, Glenville Jones and Claudio Marcocci 70. Vitamin D and osteoporosis • Peter R. Ebeling 71. Adult vitamin D deficiency—fracture and fall prevention: findings from randomized controlled trials • Bess Dawson-Hughes and Heike A. Bischoff-Ferrari 72. Randomized clinical trials of vitamin D and bone health • Sharon H. Chou and Meryl S. LeBoff 73. Calcifediol as a therapeutic • John S. Adams, Albert Shieh and Charles W. Bishop 74. Vitamin D and organ transplantation • Joseph Raphael, Emily M. Stein and Elizabeth Shane 75. Vitamin D, obesity, the metabolic syndrome and its sequelae • Barbara J. Boucher and Elina Hyppönen 76. The role of vitamin D in type 2 diabetes • Anastassios G. Pittas 77. Liver metabolism and disease • Bingning Dong 78. Vitamin D, hypertension, and cardiovascular disease • Armin Zittermann and Stefan Pilz 79. Vitamin D and renal disease • Adriana Dusso, Kevin T. Bauerle, Rong Mei Zhang and Carlos Bernal-Mizrachi 80. Vitamin D and kidney stones • Mansi Mehta and David S. Goldfarb 81. Hypercalcemia due to vitamin D toxicity • Yasaman Motlaghzadeh, John P. Bilezikian and Deborah E. Sellmeyer 82. Vitamin D and Paget’s disease • Noriyoshi Kurihara and G. David Roodman 83. Vitamin D metabolism and disorders in companion animals • Richard John Mellanby 84. Overview of vitamin D actions in cancer • Marjolein van Driel, Alberto Muñoz and Johannes P.T.M. van Leeuwen 85. Vitamin D status and cancer incidence, mortality, and prognosis • Hanseul Kim, Irene Shui and Edward Giovannucci 86. Antiproliferative and immunoregulatory actions of vitamin D derivatives on hematological malignancies: control of differentiation, proliferation, and cell death • George P. Studzinski, Elzbieta Gocek, Ewa Marcinkowska and Michael Danilenko 87. Vitamin D, inflammation, and cancer • Enikö Kallay, Martin Schepelmann and Laura Buburuzan 88. Vitamin D actions in mammary gland and breast cancer • JoEllen Welsh and Min Ji Bak 89. Vitamin D and colorectal cancer • Gemma Ferrer-Mayorga, Alberto Muñoz and José Manuel González-Sancho 90. Vitamin D in the management of lung cancer: influence of tumor stage, tumor genotype, and treatment modality • Tatiana Shaurova, Hannah Calkins, Mukund Seshadri, Candace S. Johnson and Pamela A. Hershberger 91. Vitamin D and prostate cancer • Larisa Nonn, Kirsten Krieger, Clayton Yates and Moray J. Campbell 92. Vitamin D and pancreatic cancer • Evangelina López de Maturana, Sladjana Zagorac, Núria Malats and Francisco X. Real 93. Sunlight, skin cancer and vitamin D • Rebecca S. Mason and Katie M. Dixon 94. Vitamin D and antibacterial immunity • Aiten Ismailova and John H. White 95. Vitamin D and antiviral immunity • Vandana Kalia and Surojit Sarkar 96. Vitamin D and adaptive immunity in health and disease • Drew A. Glencross, Charlotte Cheadle and Catherine M. Hawrylowicz 97. Vitamin D, microbiota, and inflammatory bowel disease • Margherita T. Cantorna and Juhi Arora 98. Vitamin D and tuberculosis • Adrian R. Martineau 99. The role of vitamin D in COVID-19 • Sebastian T. Lugg and David R. Thickett 100. Vitamin D and type 1 diabetes • Pieter-Jan Martens, Conny Gysemans and Chantal Mathieu 101. Vitamin D mechanisms of protection in multiple sclerosis • Colleen E. Hayes, Anne L. Astier and Matthew R. Lincoln 102. Vitamin D and the epidemiology of multiple sclerosis • Kassandra L. Munger and Alberto Ascherio 103. Vitamin D and rheumatoid arthritis • Stephanie Harrison, Elena Nikiphorou, Louisa Jeffery, Karim Raza and Martin Hewison 104. Psoriasis and other skin disorders • Jörg Reichrath and Michael F. Holick 105. Vitamin D, acute respiratory infection, and Asthma/COPD • Carlos A. Camargo, Jr. 106. Vitamin D and acute illness • Karin Amrein and Kenneth B. Christopher Index for Volume 2 Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike's Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including sports medicine, opthalmology, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles Chapters written by the most prominent and well-published names in the field