Feldman and Pike's Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics 5th Edition

Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike's Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.• A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles • Chapters written by the most prominent and well-published names in the field List of contributors In memoriam Preface to the fifth edition List of abbreviations Relevant lab values in adults and children 1. Book introduction: Major trends in vitamin D research • David Feldman and J. Wesley Pike 2. Evolution of human skin pigmentation and vitamin D • Nina G. Jablonski 3. Photobiology of vitamin D • Michael F. Holick and Andrzej T. Slominski 4. The activating enzymes of vitamin D metabolism (25- and 1α-hydroxylases) • Glenville Jones, David E. Prosser and Martin Kaufmann 5. CYP24A1: structure, function, and physiological role • René St-Arnaud and Glenville Jones 6. Alternative pathways for vitamin D metabolism • Andrzej T. Slominski, Robert C. Tuckey, Carl Jenkinson, Wei Li and Anton M. Jetten 7. Vitamin D—binding protein • Roger Bouillon, Rene F. Chun and Frans Schuit 8. Regulation of renal vitamin D metabolism • Mark B. Meyer, Nancy A. Benkusky, Seong Min Lee and J. Wesley Pike 9. Regulation of extra-renal synthesis of 1,25(OH)2D • Martin Hewison and John S. Adams 10. Structural basis for ligand activity in vitamin D receptor • Anna Y. Belorusova and Natacha Rochel 11. Genome-wide perspectives on vitamin D receptor actions • J. Wesley Pike, Seong Min Lee, Nancy A. Benkusky and Mark B. Meyer 12. Vitamin D, chromatin, and epigenetics • Carsten Carlberg 13. The diverse genomic mechanisms of action of the vitamin D receptor • John H. White, Fatemeh Sarmadi and Patricio Artusa 14. Vitamin D and microRNAs • Hengguang Zhao, Marianela Forcellati, Damien Buschittari, John E. Heckel1, Christopher J. Machado, Sri Ramulu N. Pullagura and Thomas S. Lisse 15. Pathway based-analysis of transcriptomic data from vitamin D studies • Chris T.A. Evelo and Susan L.M. Coort 16. Vitamin D and the kidney • Kittrawee Kritmetapak, Peter J. Tebben and Rajiv Kumar 17. Vitamin D and the calcium-sensing receptor • Chia-Ling Tu and Wenhan Chang 18. Regulation of intestinal calcium and phosphate absorption by vitamin D • James C. Fleet, Sylvia Christakos and Heng Jiang 19. Vitamin D and FGF23 • Nejla Latic and Reinhold G. Erben 20. Osteoclastogenesis and vitamin D • Yuko Nakamichi, Naoyuki Takahashi, Tatsuo Suda and Nobuyuki Udagawa 21. Vitamin D activity in osteoblasts and osteocytes • Paul H. Anderson 22. Cartilage • Barbara D. Boyan, Niels C. Asmussen, Maryam Doroudi, Kayla M. Scott and Zvi Schwartz 23. Vitamin D and bone: an integrated approach • Lieve Verlinden and Geert Carmeliet 24. Vitamin D in dentoalveolar and oral health • Brian L. Foster, Emily Y. Chu and Philippe P. Hujoel 25. Role of vitamin D in skin and hair biology • Daniel D. Bikle and Marie B. Demay 26. Vitamin D and the cardiovascular system • Adriana Dusso, Kevin T. Bauerle and Carlos Bernal-Mizrachi 27. Vitamin D, brain development and function • Darryl Eyles, Xiaoying Cui and John J. McGrath 28. Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms • Carmen J. Narvaez and JoEllen Welsh 29. Vitamin D and skeletal muscle • Christian M. Girgis 30. Understanding vitamin D from mouse knockout models • David Goltzman, Andrew C. Karapalis, Richard Kremer and Dengshun Miao 31. Pharmacology and pharmacokinetics of vitamin D • Inez Schoenmakers and Kerry S. Jones 32. Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy • Carol L. Wagner and Bruce W. Hollis 33. The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate • Brittany A. Ryan and Christopher S. Kovacs 34. Vitamin D and the placenta • Jane K. Cleal, Rohan M. Lewis and Nicholas C. Harvey 35. Consequences of perinatal vitamin D deficiency on later bone health • Rebecca J. Moon, Elizabeth M. Curtis, Jane K. Cleal, Elaine M. Dennison, Cyrus Cooper and Nicholas C. Harvey 36. Adolescence and acquisition of peak bone mass • Kevin D. Cashman, Richard Lewis and Connie M. Weaver 37. The role of vitamin D in orthopedic surgery • Aasis Unnanuntana, Katherine Haseltine, Teerapat Tutaworn, Aleksey Dvorzhinskiy and Joseph M. Lane 38. Vitamin D and muscle performance in athletes and older adults • Lisa Ceglia 39. Role in reproductive biology and dysfunction in women • Lubna Pal and Hugh S. Taylor 40. Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease • Ida Marie Boisen, Rune Holt, Ireen Kooij, Sam Kafai Yahyavi, Li Juel Mortensen and Martin Blomberg Jensen 41. Vitamin D and the renin—angiotensin system • Yan Chun Li 42. Vitamin D: presence and function in the eye • Graham R. Wallace, Saaeha Rauz and Dhruv Parekh 43. Adult vitamin D deficiency and adverse brain outcomes • Phoebe Mayne, Dana Bradford, Natalie J. Groves, John J. McGrath and Thomas H.J. Burne 44. Vitamin D and the lung • Karen Maes, Ghislaine Gayan-Ramirez and Wim Janssens 45. Design and synthesis of vitamin D analogs • Miguel A. Maestro 46. Structure function relationships of VDR ligands • Hiroyuki Kojima and Keiko Yamamoto 47. Modulating vitamin D receptor—coregulator binding with small molecules • Daniel A. Webb, Maija B. Lee and Leggy A. Arnold 48. Mass spectrometry assays of vitamin D metabolites • Martin Kaufmann, Lusia Sepiashvili and Ravinder J. Singh 49. Measurement and quality assessment of total and free 25-hydroxyvitamin D • Christopher T. Sempos, Emma L. Williams, Diane C. Krueger, Neil C. Binkley and Rene F. Chun 50 Vitamin D tissue distribution by mass spectrometry imaging • Diego F. Cobice and Karl W. Smith Index for Volume 1