Fatty Acids and Lipotoxicity in Obesity and Diabetes: Novartis Foundation Symposium 286

The Potential Lipotoxic Effect Of Accumulation Of Fatty Acids In Non-adipose Tissues Is Thought To Be A Major Component In The Development Of Insulin Resistance. Chronic Exposure To High Concentrations Of Free Fatty Acids In The Blood Affects Pancreatic 'b' Cell Function, Insulin Secretion And Lipid Synthesis In The Liver, And Storage In Adipose Tissue. Maintaining The Normal Levels Of Fatty Acids Requires Coordinated Regulation Between The Liver, Adipose Tissue And Skeletal Muscle. This Book Deals With The Molecular Aspects Of Fatty Acid Action In Obesity And Insulin Resistance. The Topics Include Lipid Metabolism And Adipose Tissue Biology, And 'b' Cell Function And Insulin Resistance. Chapters Deal With The Molecular Genetics And Molecular Physiology Of Energy Homeostasis. Transcriptional Control Of Energy Homeostasis Through The Pgc1 Coactivators / B.m. Spiegelman -- Human Obesity And Insulin Resistance: Lessons From Experiments Of Nature / S. O'rahilly -- Lipid-induced Metabolic Dysfunction In Skeletal Muscle / D.m. Muoio And T.r. Koves -- Stearoyl-coa Desaturase Deficiency, Hypercholesterolaemia, Cholestasis And Diabetes / A.d. Attie ... [et Al.] -- The Role Of Lipin 1 In Adipogenesis And Lipid Metabolism / K. Reue -- The Role Of The Amp-activated Protein Kinase In The Regulation Of Energy Homeostasis / D. Carling -- Endoplasmic Reticulum Stress And Inflammation In Obesity And Type 2 Diabetes / G.s. Hotamisligil -- The Impact Of Insulin Resistance On Macrophage Death Pathways In Advanced Atherosclerosis / I. Tabas ... [et Al.] -- Fatty Acid Transport In Adipocytes And The Development Of Insulin Resistance / S. Lobo And D.a. Bernlohr -- Vectorial Acylation: Linking Fatty Acid Transport And Activation To Metabolic Trafficking / P.n. Black And C.c. Dirusso -- Lipid Storage And Mobilization Pathways In Yeast / G. Daum ... [et Al.] -- Cide Proteins And The Development Of Obesity / J.z. Li And P. Li -- Adiponectin And Adiponectin Receptors In Obesity-linked Insulin Resistance / T. Kadowaki ... [et Al.] -- Anti-inflammatory And Antidiabetic Roles Of Ppargamma / G. Pascual ... [et Al.]. Symposium On Fatty Acids And Lipotoxicity In Obesity And Diabetes, Held At Tsinghua University, Beijing, China, 17-19 Oct. 2006. Editors: Gregory Bock And Jamie Goode. Includes Bibliographical References And Indexes. The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis. The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic ß cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics in Fatty Acid and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and beta-cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.