Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders (Research and Perspectives in Alzheimer's Disease)

## Softcover reprint of the hardcover 1 st edition 2000 The use of general descriptive names, registered names, trademarks, etc., in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Front Matter....Pages I-XII The Role of α-Synuclein in Parkinson’s Disease: A Biophysical Analogy to Aβ and Alzheimer’s Disease....Pages 1-9 Purification of Lewy Bodies and Identification of α-Synuclein as a Major Component of Lewy Bodies....Pages 11-18 Mutational Analysis of Tau in Chromosome 17-Linked Dementia....Pages 19-28 Missense and Splice Site Mutations in Tau Associated with FTDP-17 Multiple Pathogenic Mechanisms....Pages 29-51 Tau Mutations: Genetics and Pathogenetic Mechanisms....Pages 53-64 Tauopathies and α-Synucleinopathies....Pages 65-86 Distinct Tau Gene Mutations Induce Specific Dysfunctions/Toxic Properties in Tau Proteins Associated With Specific FTDP-17 Phenotypes....Pages 87-104 Neurodegenerative Disorders with Tauopathies: Mad Tau Diseases?....Pages 105-125 Tau Protein: Role in Intracellular Traffic and Development of Cell Polarity....Pages 127-138 Back Matter....Pages 139-140

In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer's Disease, Chromosome 17-Linked Dementia, Parkinson's Disease and disorders with tauopathies.