Fast Neutrons and High-LET Particles in Cancer Therapy (Recent Results in Cancer Research, 150)

Fast neutron therapy was introduced in London in 1970. The book gives an overview of the developments of the past 28 years, assesses the results of fast neutron treatment, and reviews the compiled clinical data worldwide. The authors describe the radiobiological profile of the neutron beams and evaluate the neutron RBE for secondary cancer induction, they introduce heavy-ion therapy, which combines high physical selectivity with the biological advantages of high-LET radiation for some tumor types, and finally they describe the very recent developments in Boron Neutron Capture Therapy (BNCT). Front Matter....Pages I-XIII The Physical Basis for Radiotherapy with Neutrons....Pages 1-30 Specification of Radiation Quality in Fast Neutron Therapy: Microdosimetric and Radiobiological Approach....Pages 31-53 Relative Biological Effectiveness of Neutrons for Cancer Induction and Other Late Effects: A Review of Radiobiological Data....Pages 54-87 Neutron Therapy in Malignant Salivary Gland Tumors: Results at European Centers....Pages 88-99 European Results of Neutron Therapy in Soft Tissue Sarcomas....Pages 100-112 Use of Neutron Therapy in the Management of Locally Advanced Nonresectable Primary or Recurrent Rectal Cancer....Pages 113-124 Fast Neutrons in Prostatic Adenocarcinomas: Worldwide Clinical Experience....Pages 125-136 The Role of Fast Neutrons in the Treatment of Squamous Cell Carcinomas of the Head and Neck: The European Experience....Pages 137-147 Sacrococcygeal Chordomas: Potential Role of High-LET Therapy....Pages 148-155 Complications of Fast Neutron Therapy....Pages 156-169 Is There a Role for Heavy Ion Beam Therapy?....Pages 170-182 Boron Neutron Capture Therapy: Principles and Potential....Pages 183-209 Back Matter....Pages 210-218