Extremophilic Cyanobacteria For Novel Drug Development (SpringerBriefs in Pharmaceutical Science & Drug Development)

This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities.The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as __in silico__ techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. __Extremophilic Cyanobacteria For Novel Drug Development__ provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics. Contents 5 About the Authors 7 Chapter-1 8 Introduction 8 1.1 Origin of Cyanobacteria and Evolution of Life 8 1.2 Extreme Environments Inhabited by Cyanobacteria and Their Diversity 10 1.2.1 Thermophilic Cyanobacteria 10 1.2.2 Psychrophilic Cyanobacteria 11 1.2.3 Halophilic Cyanobacteria 11 1.2.4 Acidophilic Cyanobacteria 12 1.2.5 Alkaliphilic Cyanobacteria 12 1.2.6 Heavy Metal Tolerant Cyanobacteria 13 1.2.7 Radiation-Resistant Cyanobacteria 13 1.3 Survival Strategy of Extremophilic Cyanobacteria 15 1.3.1 Avoidance Mechanism 15 1.3.2 Stress Defense Activities 17 1.3.3 Repair Mechanism 19 1.4 Changes in Metabolic Activities of Cyanobacteria Under Stress 20 1.5 Cyanobacteria as a Promising Candidate for New Pharmaceutical Compounds 21 References 24 Chapter-2 30 Secondary Metabolites of Cyanobacteria and Drug Development 30 2.1 Secondary Metabolic Pathways Found in Cyanobacteria 30 2.2 Recent Advances in Novel Secondary Metabolites Discovery from Cyanobacteria 34 2.2.1 Epigenetic-Related Approaches 35 2.2.2 Genome-Driven Approaches 36 2.2.3 Analytics and Preparative Strategies for Accessing New Natural Products 37 2.3 In silico Screening for Novel Secondary Metabolites of Cyanobacteria 39 2.4 Novel Biosynthetic Gene Cluster in Cyanobacteria 43 References 46 Chapter-3 51 Glycoconjugates of Cyanobacteria and Potential Drug Development From Them 51 3.1 Glycoconjugates of Cyanobacteria 51 3.2 Glycan Biosynthesis in Cyanobacteria 53 3.3 Glycotherapy Using Cyanobacterial Glycoconjugates 54 3.4 Cyanobacterial Glycans as Drug Delivery Device 57 3.5 Glycoconjugate Vaccines 60 References 64 Chapter-4 69 Anticancer Drug Development from Cyanobacteria 69 4.1 Cyanobacterial Metabolites with Potential Anticancer Properties 69 4.2 Cytotoxicity of Cyanobacterial Natural Product 72 4.3 Apoptosis and Cyanobacterial Natural Product 75 4.4 Drug Delivery System with Cellular Targets 78 References 79 Chapter-5 85 Issues and Challenges of Drug Development from Cyanobacteria 85 5.1 Clinical Trial and Commercial Drug Development 85 5.2 Challenges of Drug Development in Cyanobacteria 88 5.3 Future Prospects 91 References 93 Index 96 "This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activitiesThe second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics - Font no determinada This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities. The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics Front Matter....Pages i-vii Introduction....Pages 1-22 Secondary Metabolites of Cyanobacteria and Drug Development....Pages 23-43 Glycoconjugates of Cyanobacteria and Potential Drug Development From Them....Pages 45-62 Anticancer Drug Development from Cyanobacteria....Pages 63-78 Issues and Challenges of Drug Development from Cyanobacteria....Pages 79-89 Back Matter....Pages 91-92