Extravasation of Cytotoxic Agents : Compendium for Prevention and Management

Extravasation of cytotoxic drugs can lead to serious complications during tumour therapy. This volume is intended as an aid to assess the situation quickly and conclusively should this emergency occur. The substance specific section of the book provides detailed instructions for how to deal with 49 cytotoxic agents so that targeted measures can be started at once. The general section provides comprehensive information on prevention, general measures to be taken in case of extravasation, specific antidotes, and documentation. For support during everyday clinical practice, the book is accompanied by a template for an extravasation kit, tables, documentation sheets, and patient information. The book is the outcome of a consensus of an interdisciplinary working group that has collected and systematically reviewed all published literature on the topic. The practical instructions are accompanied by a review of the literature to enable readers to study source materials via the original published studies. Front Matter....Pages I-IX Problem outline....Pages 1-2 Front Matter....Pages 3-3 Introduction....Pages 5-7 Predisposition and prevention....Pages 8-14 Clinic....Pages 15-19 Measures....Pages 19-55 Front Matter....Pages 57-57 Amsacrine....Pages 59-62 L-Asparaginase....Pages 63-65 Bendamustine....Pages 66-68 Bleomycin....Pages 69-72 Busulfan....Pages 73-75 Carboplatin....Pages 76-78 Carmustine....Pages 79-82 Cisplatin....Pages 83-88 Cladribine....Pages 89-91 Cyclophosphamide....Pages 92-94 Cytarabine....Pages 95-97 Dacarbazine....Pages 98-102 Dactinomycin....Pages 103-106 Daunorubicin....Pages 107-111 Daunorubicin liposomal....Pages 112-115 Front Matter....Pages 57-57 Docetaxel....Pages 116-119 Doxorubicin....Pages 120-130 Doxorubicin liposomal....Pages 131-133 Epirubicin....Pages 134-138 Estramustine....Pages 139-141 Etoposide....Pages 142-145 Etoposide phosphate....Pages 146-148 Fludarabine....Pages 149-151 5-Fluorouracil....Pages 152-156 Fotemustine....Pages 157-159 Gemcitabine....Pages 160-162 Idarubicin....Pages 163-166 Ifosfamide....Pages 167-170 Irinotecan....Pages 171-173 Melphalan....Pages 174-176 Methotrexate....Pages 177-180 Mitomycin C....Pages 181-187 Mitoxantrone....Pages 188-192 Nimustine....Pages 193-194 Oxaliplatin....Pages 195-197 Front Matter....Pages 57-57 Paclitaxel....Pages 198-204 Pegaspargase....Pages 205-206 Pentostatin....Pages 207-209 Raltitrexed....Pages 210-212 Streptozocin....Pages 213-215 Teniposide....Pages 216-219 Thiotepa....Pages 220-222 Topotecan....Pages 223-225 Treosulfan....Pages 226-228 Trimetrexate....Pages 229-231 Vinblastine....Pages 232-237 Vincristine....Pages 238-244 Vindesine....Pages 245-249 Vinorelbine....Pages 250-253 Back Matter....Pages 255-258 Extravasation of cytotoxic drugs can lead to serious complications during tumour therapy. This volume is intended as an aid to assess the situation quickly and conclusively, should this emergency occur. The substance-specific section of the book provides detailed instructions on how to deal with 49 cytotoxic agents so that targeted measures can be started at once. The general section provides comprehensive information on prevention, general measures to be taken in case of extravasation, specific antidotes, and documentation. The book is the outcome of a consensus of an interdisciplinary working group that has collected and systematically reviewed all published literature on the topic.