Extrachromosomal DNA : proceedings of the 1979 ICN-Ucla symposia on Molecular and Cellular Biology held in Keystone, Colorado, march 11-16, 1979

Extrachromosomal DNA contains the proceedings of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology held in Keystone, Colorado. Contributors focus on extrachromosomal DNA, paying particular attention to the biogenesis of yeast mitochondria. They discuss topics based on the premise that the diversity and complexity of primitive mitochondrial and perhaps chloroplast DNA structure and replication have more in common with many viral systems than with either prokaryotic or eukaryotic systems. This is especially striking in the case of so-called split genes. This book is organized into nine sections encompassing 34 chapters and begins with an overview of extranuclear genetics and the evolution and regulation of mitochondrial biogenesis. The following chapters explore the genetic capacity and structure of chloroplast DNA, viral replication and function, and viral nucleic acids. The possibility of isolating mutants in some intervening sequences and analyzing their effect in loci of known genetic function is demonstrated. The reader is also introduced to the analysis of intervening genes and its importance in yeast mitochondria, as well as the sequencing of a variety of genes of known function. This book also considers the organization, function, and expression of extrachromosomal DNA in yeast, along with the genetics and biogenesis of mitochondrial DNA from higher eukaryotes, and then concludes with a description of the biological and structural characteristics of kinetoplast and Podospora mitochondrial DNA. This book will be of interest to researchers involved in mitochondrial, chloroplast, plasmid, and viral DNA function and replication. Content: Academic Press Rapid Manuscript Reproduction , Page ii Front Matter , Page iii Copyright , Page iv CONTRIBUTORS , Pages ix-xiv PREFÁCE , Pages xv-xvi EXTRANUCLEAR GENETICS , Pages 1-10 , G.H. Beale MITOCHONDRIAL BIOGENESIS: EVOLUTION AND REGULATION , Pages 11-33 , Henry R. Mahler Restriction Enzyme Analysis of Mitochondrial DNA from Closely Related Species of Paramecium , Pages 35-51 , Donald J. Cummings, Arthur E. Pritchard, Richard A. Maki THE EXTRACHROMOSOMAL RIBOSOMAL RNA GENES IN TETRAHYMENA ; STRUCTURE AND EVOLUTION , Pages 53-61 , J. Engberg, Nanni Din MOLECULAR HETEROGENEITY AMONG MITOCHONDRIAL DNAS FROM DIFFERENT MAIZE CYTOPLASMS , Pages 63-73 , C.S. Levings III, D.M. Shah, W.W.L. Hu, D.R. Pring, D.H. Timothy GENETIC ANALYSIS OF CHLOROPLAST DNA FUNCTION IN CHLAMYDOMONAS , Pages 75-96 , Nicholas W. Gillham, John E. Boynton, David M. Grant, Hurley S. Shepherd, Edwin A. Wurtz METHYLATION AND RESTRICTION OF CHLOROPLAST DNA: THE MOLECULAR BASIS OF MATERNAL INHERITANCE IN CHLAMYDOMONAS , Pages 97-112 , Ruth Sager GENES ON THE MAIZE CHLOROPLAST CHROMOSOME , Pages 113-126 , Lawrence Bogorad, Gerhard Link, Lee McIntosh, Setsuko O. Jolly CHLOROPLAST DNA OF EUGLENA GRACILIS GENE MAPPING AND SELECTIVE IN VITRO TRANSCRIPTION OF THE RIBOSOMAL RNA REGION , Pages 127-141 , Richard B. Hallick, Keith E. Rushlow, Emil M. Orozco Jr., Gary L. Stiegler, Patrick W. Gray THE MU PARADOX: EXCISION VERSUS REPLICATION , Pages 143-154 , Hajra Khatoon, George Chaconas, Michael DuBow, Ahmad I. Bukhari INTEGRATION OF TRANSPOSABLE DNA ELEMENTS: ANALYSIS BY DNA SEQUENCING , Pages 155-164 , Nigel D.F. Grindley IN VITRO REPLICATION OF ADENOVIRUS DNA , Pages 165-176 , Thomas J. Kelly Jr., Mark D. Challberg SELECTIVE CONSERVATION OF THE ORIGINS OF DNA REPLICATION (GENOMIC TERMINI) IN SPONTANEOUS DELETION MUTANTS OF THE PARVOVIRUS MVM , Pages 177-198 , Emanuel A. Faust, David C. Ward COMPLEX STRUCTURES AND NEW SURPRISES IN SV40 mRNA , Pages 199-215 , Michael Piatak, Prabat K. Ghosh, V. Bhaskara Reddy, Paul Lebowitz, Sherman M. Weissman STRUCTURE AND ORGANIZATION OF ADENOVIRUS 5 TRANSFORMATION GENES , Pages 217-234 , A.J. van der Eb, H. van Ormondt, P.I. Schrier, H. Jochemsen, J.H. Lupker, P.J. van den Elsen, J. Maat, C.P. van Beveren, A. de Waard THE EPSTEIN-BARR VIRUS PLASMID , Pages 235-248 , Joseph S. Pagano THE INFLUENCE OF THE NUCLEAR AND MITOCHONDRIAL GENOMES ON THE EXPRESSION OF MITOCHONDRIAL DNA IN SACCHAROMVCES CEREVISIAE , Pages 249-267 , Anthony W. Linnane, Anne Astin, Sangkot Marzuki, Mark Murphy, Stuart C. Smith GENETIC AND BIOCHEMICAL ANALYSIS OF VARI , Pages 269-286 , Ronald A. Butow, Peter Terpstra, Robert L. Strausberg TRANSCRIPTION OF YEAST MITOCHONDRIAL DNA , Pages 287-304 , David Levens, John Edwards, Joseph Locker, Arthur Lustig, Sylvie Merten, Richard Morimoto, Richard Synenki, Murray Rabinowitz TRANSCRIPTS OF YEAST MITOCHONDRIAL DNA AND THEIR PROCESSING , Pages 305-324 , L.A. Grivell, A.C. Arnberg, P.H. Boer, P. Borst, J.L. Bos, E.F.J. van Bruggen, G.S.P. Groot, N.B. Hecht, L.A.M. Hensgens, G.J.B. van Ommen, H.F. Tabak THE EXPRESSION IN SACCHAROMYCES CEREVISIAE OF BACTERIAL β-LACTAMASE AND OTHER ANTIBIOTIC RESISTANCE GENES INTEGRATED IN A 2-μm DNA VECTOR , Pages 325-338 , Cornells P. Hollenberg ORGANIZATION OF MITOCHONDRIAL DNA IN YEAST , Pages 339-355 , Alexander Tzagoloff, Giuseppe Macino, Marina P. Nobrega, May Li IDENTIFICATION AND SEQUENCING OF YEAST MITOCHONDRIAL tRNA GENES IN MITOCHONDRIAL DNA - pBR322 RECOMBINANTS , Pages 357-375 , Nancy C. Martin, Dennis L. Miller, John E. Donelson, Chris Sigurdson, James L. Hartley, Patrick S. Moynihan, Hung Dinh Pham MITOCHONDRIAL tRNAs AND rRNAs of NEUROSPORA CRASSA: SEQUENCE STUDIES, GENE MAPPING AND CLONING , Pages 377-394 , U.L. RajBhandary, J.E. Heckman, S. Yin, B. Alzner-DeWeerd STRUCTURE AND EVOLUTION OF ANIMAL MITOCHONDRIAL DNA , Pages 395-407 , Igor B. Dawid, Eva Rastl STRUCTURE AND REPLICATION OF MITOCHONDRIAL DNA FROM THE GENUS DROSOPHILA , Pages 409-425 , David R. Wolstenholme, Judy M. Goddard, Christiane M.-R. Fauron TRANSCRIPTION PATTERN OF DROSOPHILA MELANOGASTER MITOCHONDRIAL DNA , Pages 427-442 , Jim Battey, John L.R. Rubenstein, David A. Clayton THE ORGANIZATION OF THE GENES IN THE HUMAN MITOCHONDRIAL GENOME AND THEIR MODE OF TRANSCRIPTION , Pages 443-469 , Giuseppe Attardi, Palmiro Cantatore, Edwin Ching, Stephen Crews, Robert Gelfand, Christian Merkel, Deanna Ojala CLONING OF HUMAN MITOCHONDRIAL DNA , Pages 471-483 , Jacques Drouin, Robert H. Symons QUANTITATION OF INTRAPOPULATION VARIATION BY RESTRICTION ENDONUCLEASE ANALYSIS OF HUMAN MITOCHONDRIAL DNA , Pages 485-499 , Wesley M. Brown, Howard M. Goodman RESTRICTED MITOCHONDRIAL DNA FRAGMENTS AS GENETIC MARKERS IN CYTOPLASMIC HYBRIDS , Pages 501-514 , Ching Ho, Hayden G. Coon STRUCTURE AND FUNCTION OF KINETOPLAST DNA OF THE AFRICAN TRYPANOSOMES , Pages 515-531 , P. Borst, J.H.J. Hoeijmakers REPLICATION AND TRANSCRIPTION OF KINETOPLAST DNA , Pages 533-548 , Larry Simpson, Agda M. Simpson, H. Masuda, H. Rosenblatt, N. Michael, G. Kidane MITOCHONDRIAL DNA AND SENESCENCE IN PODOSPORA ANSERINA , Pages 549-559 , Donald J. Cummings, Leon Belcour, Claude Grandchamp INDEX , Pages 561-564