Expression of FGF Receptors 1, 2, 3 in the Embryonic and Postnatal Mouse Brain Compared with __Pdgfrα, Olig2__ and __Plp/dm20:__ Implications for Oligodendrocyte Development

Fibroblast growth factors (FGF) receptors __FgfR1__, __FgfR2__ and __FgfR3__ are differentially regulated during oligodendrocyte (OL) maturation in vitro: __FgfR3__ is expressed by OL progenitors whereas __FgfR2__ is expressed by differentiated OLs[Mol Cell Neurosci 1996;7:263–275], and we have recently shown that __FgfR3__ is required for the timely differentiation of OLs in vivo [J Neurosci 2003;23:883–894].Here we have used in situhybridization to investigate the expression patterns of __FgfR1–3__ and compare them to the putative OL progenitor markers __Olig2, Pdgfr__α____and __Plp/dm20__ as a function of development in vivo, in particular at sites of OL specification, migration or differentiation in the mouse forebrain and cerebellum. We show that at early stages __FgfR1–3__ expression overlaps with that of __Olig2__ in the embryonic ventricular zone of the lateral and medial ganglionic eminences. Further, a scattered population of cells expressing __FgfR3__ (but not __FgfR1__ or __FgfR2__) in the ventral telencephalon appear to arise from the ventricular zone, and at later stages are found more dorsally in the cortex, in an overall pattern similar to __Olig2__ and/or __Pdgfr__α____. Postnatal expression of __FgfR2__ increases with age, more prominently in specific regions, including the cortical and cerebellar white matter and optic nerve. Thus, the differential expression pattern of __FgfR2__ and __FgfR3__ observed in vivo suggests that their expression is developmentally regulated in a manner consistent with the pattern of their expression in culture. These data provide further insights into role of __FgfRs__ in OL development, and they emphasize that these receptors are positioned both spatially and temporally to impact OL generation in vivo. Contents......Page 4 Expression of FGF Receptors 1, 2, 3 in the Embryonic and Postnatal Mouse Brain Compared with Pdgfra, Olig2and Plp/dm20: Implications for Oligodendrocyte Development......Page 6 Soma-Restricted Products of the Myelin Proteolipid Gene Are Expressed Primarily in Neurons in the Developing Mouse Nervous System......Page 19 Origin of the Cortical Layer I in Rodents......Page 28 Regionally Specific Effects of BDNF on Oligodendrocytes......Page 39 Tachykinin Expression and Localization in Developing Feline Neocortex......Page 50 Beyond Laminar Fate: Toward a Molecular Classification of Cortical Projection/Pyramidal Neurons......Page 62 Highly Efficient Gene Transduction into the Brain Using High-Titer Retroviral Vectors......Page 75 Extrinsic and Intrinsic Factors Governing Cell Fate in Cortical Progenitor Cultures......Page 85 Serotonergic Regulation of Somatosensory Cortical Development: Lessons from Genetic Mouse Models......Page 96 Neural Stem Cells in the Subventricular Zone Are a Source of Astrocytes and Oligodendrocytes, but Not Microglia......Page 107 Differential Regulation of Thalamic and Cortical Axonal Growth by Hepatocyte Growth Factor/Scatter Factor......Page 120 Control of Astrocyte Migration in the Developing Cerebral Cortex......Page 130 The Cortical Ancestry of Oligodendrocytes: Common Principles and Novel Features......Page 140 Dynamic Patterned Expression of Orphan Nuclear Receptor Genes RORα and RORβ in Developing Mouse Forebrain......Page 157 The Role of Serotonin in Early Cortical Development......Page 168 Distinguishing Features of Progenitor Cells in the Late Embryonic and Adult Hippocampus......Page 180 Ontogeny and Plasticity of Adult Hippocampal Neural Stem Cells......Page 196 GRO-α and CXCR2 in the Human Fetal Brain and Multiple Sclerosis Lesions......Page 202 Author Index......Page 214 Subject Index......Page 215 This special issue highlights the development of the mammalian forebrain, particularly the cerebral cortex. A special focus lies on the many factors that influence the development of neurons and glia in forebrain structures. All articles have been written by leading scientists, well known in the area of neuronal and glial development. Topics include recent findings about the factors influencing the fate of stem cells in the cortex and hippocampus; the origin, mapping and development of cortical layers; the role of growth factors, neurotransmitters and their receptors in neuronal and glial development; the regulation of cortical and thalamic axonal growth; the expression of genes during forebrain development; and the control of neuronal and glial migration in the cortex. This publication will be of interest to anyone studying brain development, neuronal and glial differentiation, cell migration and process extension in the nervous system. Annotation. This special issue highlights the development of the mammalian forebrain, particularly the cerebral cortex. A special focus lies on the many factors that influence the development of neurons and glia in forebrain structures. All articles have been written by leading scientists, well known in the area of neuronal and glial development. Topics include recent findings about the factors influencing the fate of stem cells in the cortex and hippocampus; the origin, mapping and development of cortical layers; the role of growth factors, neurotransmitters (Brain Development with a Focus on the Cortex) and their receptors in neuronal and glial development; the regulation of cortical and thalamic axonal growth; the expression of genes during forebrain development; and the control of neuronal and glial migration in the cortex