Explorations in Aging

The three of us, working in different institutions but in the same city, were very aware of the differences between our diverse approaches to the biology of aging and our perceptions of the sub­ ject matter. However, three years ago we began to hold informal meetings to discuss our research. These meetings eventually be­ came more frequent and, with this association, we became increas­ ingly cognizant of the commonality of our research problems de­ spite our separate perspectives. The idea for this symposium, therefore, grew from our aware­ ness that the underlying problem of the biological basis for aging was a common denominator in our research. The papers presented here represent three areas of active investigation: cell divi­ sion, biological membranes and hormonal regulation. They are sub­ mitted with the expectations that a greater understanding of the role of each of these separate approaches will help clarify, not only the interrelationships between our fields of research, but more importantly, the biology of aging itself. ACKNOWLEDGEMENTS We would like to extend our sincere thanks for the interest and contributions of the companies listed below: Abbott Laboratories Hoffman-LaRoche Arthur D. Little McNeil Laboratories Bristol Laboratories Mead Johnson & Company Burroughs H'ellcome Co. Merck Sharp & Dohme Research Labs. Charles River Breeding Labs. Rom-Amer Pharmaceuticals Dow Chemical Co. Sandoz Pharmaceuticals E.R. Squibb & Sons, Inc. Schering Corp. Eli Lilly Research Laboratories Smith Kline Corp. Front Matter....Pages i-ix Regulation of Cell Division in Aging Mouse Mammary Epithelium....Pages 1-19 Age Dependent Decline in Proliferation of Lymphocytes....Pages 21-37 The Regulation of Cellular Aging by Nuclear Events in Cultured Normal Human Fibroblasts (WI-38)....Pages 39-55 Hydrocortisone as a Modulator of Cell Division and Population Life Span....Pages 57-79 General Considerations of Membranes....Pages 81-94 Function of Cardiac Muscle in Aging Rat....Pages 95-118 Changes in Cardiac Membranes as a Function of Age with Particular Emphasis on Reactivity to Drugs....Pages 119-148 Changes in Protein Synthesis in Heart....Pages 149-162 Senescence and Vascular Disease....Pages 163-193 Changes in Hormone Binding and Responsiveness in Target Cells and Tissues During Aging....Pages 195-208 Regulation of Corticosterone Levels and Liver Enzyme Activity in Aging Rats....Pages 209-228 Aging and the Regulation of Hormones: A View in October 1974....Pages 229-238 Aging and the Disposition of Glucose....Pages 239-249 The Scientist and Social Policy on Aging....Pages 251-261 Cell Types Originating from Young and Old Mouse Kidney Explants....Pages 263-264 Alterations in the Growth Rate and Glucose Metabolism of Chinese Hamster Cells in Vitro....Pages 265-265 The Cristofalo Indices of Mutant Human Cells....Pages 266-267 Altered DNA Metabolism in Aged and Progeric Fibroblasts....Pages 268-268 The Survival of Haploid and Diploid Vertebrate Cells after Treatment with Mutagens....Pages 269-269 Capacity of Cultured Fibroblasts from Different Mammalian Species to Metabolize 7,12-Dimethylbenz (A) Anthracene to Mutagenic Metabolites: A Correlation with Lifespan....Pages 270-270 Extension of the in Vitro Lifespan of Human WI-38 Cells in Culture by Vitamin E....Pages 271-271 Diminished Inotropic Response to Catecholamines in the Aged Myocardium....Pages 272-274 Studies in Age-Related Ion Metabolism in Rat Myocardium....Pages 275-275 The Effects of Isoproterenol Stress on the Hearts of Old and Young Rats....Pages 276-279 The Effect of Age and Fasting on Serum Cholesterol Levels and Cholesterol Esterification in the Rat....Pages 280-280 Lipid Metabolism in Aging Rats....Pages 281-282 Exercise, Thyroid Secretion Rate and Lipid Metabolism in Rats....Pages 283-283 Accelerated Aging of the Brain: Neuroendocrine Studies in Huntingdon’s Disease....Pages 284-285 Changes in Brain Adenosine — 3′5′ — Monophosphate in the Aging Rat....Pages 286-288 Evidence Relating the Amount of Albumin mRNA to the Increased Albumin Synthetic Activity Observed in Old Rats....Pages 289-290 Properties of Catalase Molecules in Rats of Different Ages....Pages 291-292 Thermal Denaturation of Biomolecules at Normal Body Temperature....Pages 293-293 Back Matter....Pages 295-307 The three of us, working in different institutions but in the city, were very aware of the differences between our diverse approaches to the biology of aging and our perceptions of the subject matter. However, three years ago we began to hold informal stings to discuss our research. These meetings eventually become frequent and, with this association, we became increasely cognizant of the commonality of our research problems despite our separate perspectives. The idea for this symposium, therefore, grew from our awareness that the underlying problem of the biological basis for aging a common denominator in our research. The papers presented here represent three areas of active investigation: cell division, biological membranes and hormonal regulation. They are submitted with the expectations that a greater understanding of the role of each of these separate approaches will help clarify, not only the interrelationships between our fields of research, but lure importantly, the biology of aging itself.