Experimental Toxicology : The Basic Issues

Experimental Toxicology is an important text for undergraduates, post-graduates and professionals involved with studying or teaching this often controversial subject. It addresses the basic issues concerned with the practice of experimental toxicology and discusses in detail the following topics: experimental design; biochemical issues; animal husbandry; species differences; immunological issues; carcinogenesis; reproductive approaches; statistics; genetics; in vitro and molecular approaches; risk assessment; information resources; aspects of legislation; good laboratory practice; and laboratory design. The book has been updated and revised to reflect the many changes that have taken place since the first edition was published five years ago and this 2nd Edition gives special attention to the extensive changes that have taken place in the areas of molecular, genetic and reproductive toxicology and in the knowledge regarding the multiplicity of enzymes involved in foreign compound metabolism. Experimental Toxicology is a must for newcomers to the field who wish to gain an understanding of what toxicology is all about. It will also be of interest to experienced practitioners and to professionals from other areas who need a rapid introduction to the subject. Recoge: Introduction to experimental toxicology / D.M. Conning -- Effects of physical form, route and species / A.B. Wilson -- Influence of animal species, strain, age, hormonal and nutritional status / F.J.C. Roe -- Experimental design / A.B. Wilson -- Biochemical principles of toxicology / W.N. Aldridge -- Animal husbandry / A.B.G. Lansdown -- Inhalation toxicology / R.A. Riley, D.M. Conning -- Histopathology in safety evaluation / J.G. Evans, W.H. Butler -- Metabolism and disposition of xenobiotics / S.D. Gangolli, J.C. Phillips -- Theory and practice in metabolic studies / J.C. Phillips, S.D. Gangolli -- Immunotoxicology: conceptual problems / H. Amos -- Perspectives: the evaluation of reproductive toxicity and teratogenicity / A.B.G. Lansdown -- Genetic toxicology / Diana Anderson -- Molecular toxicology / P. Rumsby -- Testing for carcinogenicity / P. Grasso -- In vitro methods for teratology testing / Diana Anderson -- Assessing chemical injury in the reproductive system / S.D. Gangolli, J.C. Phillips -- Statistics / P.N. Lee -- Risk assessment of chemicals / D.P. Lovell--Epidemiology / G.M. Paddle -- Information and consultancy services in toxicology / D.M. Conning -- Regulations and advisory requirements in relation to food / D.M. Conning -- Influence of a growing environmental awareness on toxicology laboratory design / Diana Anderson, B. Copeland -- Good laboratory practice / R.I. Hawkins -- Ethics in experiments on animals / D.B. McGregor Front Cover......Page 1 Front Pages......Page 3 Contributors......Page 7 Contents......Page 9 Introduction to Experimental Toxicology......Page 17 Eflects of Physical Form, Route, and Species......Page 20 Znfluence of Animal Species, Strain, Age, Hormonal, and Nutritional Status......Page 39 Experimental Design......Page 51 The Biochemical Principles of Toxicology......Page 72 Animal Husbandry......Page 98 Inhalation Toxicology......Page 123 Histopathology in Safety Evaluation......Page 135 The Metabolism and Disposition of Xenobiotics......Page 146 Theory and Practice in Metabolic Studies......Page 197 Immunotoxicology-Conceptual Problems......Page 218 Perspectives-the Evaluation of Reproductive Toxicity and Teratogenicity......Page 230 Genetic Toxicology......Page 259 Molecular Toxicology......Page 329 Testing for Carcinogenicity......Page 350 In Vitro Methods for Teratology Testing......Page 376 Assessing Chemical Injury to the Reproductive System......Page 392 Statistics......Page 421 Risk Assessment of Chemicals......Page 458 Epidemiology......Page 480 Information and Consultancy Services in Toxicology......Page 501 Regulations and Advisory Requirements in Relation to Food......Page 507 The Influence of a Growing Environmental Awareness on Laboratory Design......Page 521 Good Laboratory Practice......Page 539 Ethics in Experiments on Animals......Page 558 tndex......Page 570 Back Cover......Page 583