Experimental Production Of Diseases: Part 5 Liver (handbook Of Experimental Pharmacology / Erzeugung Von Krankheitszuständen Durch Das Experiment / Experimental Production Of Diseases)

An understanding ofthe mechanisms ofheqtic injury is facilitated by an analysis of the forms of injury produced by various chemical agents. Indeed, combining the available information of the type of injury with information on mechanisms permits a useful classification of toxic agents [638]. ## I. Changes Observed by Light Microscopy Chemical or biologic substances can produce mainly damage to hepatocytes or mainly interference with bile flow [342, 418; 269, 638, 639]. The former is often referred to as the cytotoxic type and the latter as the chofestatic type of hepatic injury (Table 1). The injury may be acute or chronic. \* Under some conditions, and in some species, aflatoxins produce steatosis and under other conditions necrosis or both steatosis and necrosis. (See Section on Aflatoxins.) \* For rats 40 to 300 mg/Kg depending on the alkaloid (see Ref. 352). \*\* For rats 4 to 3 mg/Kg depending on the alkaloid (see Ref. 352). \* For the mouse a dose of 2 mg/kg. \*\* For the mouse doses in excess of 0.1 mg/kg.• Front Matter....Pages II-XV Experimental Hepatotoxicity....Pages 1-120 Liver Disease Due to Infection and Allergy....Pages 121-225 Radiation-Induced Injury of the Liver....Pages 227-304 Experimental Production of Gallstones....Pages 305-312 Back Matter....Pages 313-380