Experimental Myopathies And Muscular Dystrophy: Studies In The Formal Pathogenesis Of The Myopathy Of 2,4-dichlorophenoxyacetate (schriftenreihe Neurologie Neurology Series)

Experimental Myopathies and Muscular Dystrophy. A Study of the Formal Pathogenesis of Primary Myopathies as Exemplified in the Myopathy of 2,4-Dichlorophenoxyacetic Acid The histochemical types of muscle fibres are described and a report presented of the histological and histochemical altera tions in skeletal muscles (tibialis anterior, gastrocnemius and soleus muscles) of rats given intraperitoneal injections of the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-0). The liver and myocardium of the experimental animals were also examined. In skeletal muscle, alterations occurring acutely within 1 to 1. 5 h after injection of a single dose of 300 mg/kg 2,4-0 could be distinguished from changes which developed subacutely in the course of treatment with repeated injections of one quarter to one half of the LDSO of the substance. In both con ditions white (type 2B/Am) muscle fibres were involved pre dilectively. The principal histochemical effect of acute intoxi cation observed was leakage of phosphorylase and glycogen from white muscle fibres, whereas some of the red fibres (type 2A/C) m showed an increase in primary glycogen and phosphorylase activ ity. These changes, which must be considered nonspecifi~, were established by use of a gelatin incubation technique. They occurred as typical findings in the middle and deep areas of the anterior tibial muscle. In other muscles or different layers of the same muscle, these changes varied considerably in degree. Thus the gastrocnemius and soleus muscles displayed only minor or no alterations Front Matter....Pages I-VI Indroduction....Pages 1-2 Experimental Myopathies....Pages 3-14 The Myopathy of 2,4-Dichlorophenoxyacetic Acid (2,4-D) in the Rat....Pages 15-15 Material, Methods and Remarks....Pages 16-22 Fibre Types of Normal Skeletal Muscle....Pages 23-28 Results....Pages 29-50 Discussion and Conclusions....Pages 51-58 Relationship between the Myopathy of 2,4-D and Other Experimental Myopathies. Formal Pathogenetic Relationship to Muscular Dystrophy in Man....Pages 59-64 Summary....Pages 65-67 Back Matter....Pages 68-100