Experimental Hematology Today: 5th Annual Meeting, August 17-20, 1976, Washington D.C., USA (Experimental Hematology Today, 1977)

Front Matter....Pages i-xviii Front Matter....Pages 1-1 The Appearance of the Multipotential Hemopoietic Stem Cell....Pages 3-10 An Immunologic Approach to Cell Cycle Analysis of the Stem Cell....Pages 11-19 Physical Separation of the Cycling and Noncycling Compartments of Murine Hemopoietic Stem Cells....Pages 21-27 Characterization of Bone Marrow and Lymph Node Repopulating Cells by Transplanting Mononuclear Cells into Radiated Dogs....Pages 29-38 Front Matter....Pages 39-39 Concepts and Observations on the Regulation of Granulocyte Production....Pages 41-49 The Regulatory Role of the Macrophage in Normal and Neoplastic Hemopoiesis....Pages 51-62 Humoral Regulation of Eosinophil Granulocytopoiesis....Pages 63-70 Studies of the Erythroid Inductive Microenvironment in Vitro....Pages 71-80 In Vivo Colony Forming Unit Population Sizes in Hypertransfused SI/SI d Mice....Pages 81-85 Front Matter....Pages 87-87 Recognition of Hemopoietic Progenitors....Pages 89-91 Relationships between Early Hemopoietic Progenitor Cells Determined by Correlation Analysis of Their Numbers in Individual Spleen Colonies....Pages 93-101 Some Characteristics of in Vitro Erythroid Colony and Burst-Forming Units....Pages 103-110 Colony-Forming Unit, Megakaryote (CFU-m): Its Use in Elucidating the Kinetics and Humoral Control of the Megakaryocytic Committed Progenitor Cell Compartment....Pages 111-123 Front Matter....Pages 125-125 Negative and Positive Feedback Control of the Committed Granulocytic Stem Cell Compartment....Pages 127-134 Colony-Stimulating Factor and the Differentiation of Granulocytes and Macrophages....Pages 135-146 Characteristics of the in Vitro Monocyte-Macrophage Colony-Forming Cells Detected within Mouse Thymus and Lymph Nodes....Pages 147-156 Physical Characterization of a Subpopulation of Granulocyte/Monocyte Progenitor Cells (CFU-c)....Pages 157-163 Cell-Factor Interaction in Populations of Normal and Leukemic Blood Cells....Pages 165-176 Front Matter....Pages 177-177 Bone Marrow Transplantation Immunology....Pages 179-183 Modulation of Graft-versus-Host (GvH) Disease in the Rat; Effect of Hydroxyurea on the Mixed Lymphocyte Reaction and Graft-versus-Host Reactivity....Pages 185-190 Front Matter....Pages 177-177 Mechanism of Donor to Host Tolerance in Rat Bone Marrow Chimeras....Pages 191-197 Effects of a Cell-Free Helper Factor(s) on the Kinetics of T-Cell Responses to Histocompatibility Antigens....Pages 199-203 Front Matter....Pages 205-205 The E(AkR)-Leukemia as Murine Model of Human Acute Lymphoid Leukemia for Immunotherapy Trials....Pages 207-210 Experimental Chemotherapy: A Rat Model for Human Acute Myeloid Leukemia....Pages 211-219 Serum Colony Stimulating Factor: A Marker for Graft-versus-Host Disease in Humans....Pages 221-231 Changes in Human Bone Marrow Colony-Forming Cells following Chemotherapy Using an Agar Diffusion-Chamber Technique....Pages 233-237 Graft-versus-Leukemia, Donor Selection for Adoptive Immunotherapy in Mice....Pages 239-246 Back Matter....Pages 247-251 It is perhaps not too much of an exaggeration to claim that experimental hematology as it flourishes today originated largely from the pioneering attempts to protect lethally radiated animals (1) by shielding of hemopoietic tissues by L.O. Jacobson (9), and (2) by treatment with bone marrow suspensions by E. Lorenz and his col laborators (12). The site chosen for this annual meeting of the International Society for Experi mental Hematology is given a special historic sig nificance by the fact that it was 25 years ago that the first publication on this subject by Lorenz ap peared from his laboratory at the National Insti tutes of Health. Lorenz's discovery marked the beginning of a period which lasted until 1956, during which the protection afforded by hemopoietic cell suspensions was confirmed by many. This soon led to an intensive scientific de bate on the mechanism of this protective effect: was it due to a humoral factor produced and pro vided by the bone marrow-as Lorenz The Appearance of postulated-or to transplantation and subsequent proliferation of hemop- etic cells? This question was defini- 1 the Multipotential tively answered in 1956 by evidence from three different laboratories (7, 15, 26), which demonstrated the origin of the cells Hemopoietic in the repopulated tissues using a variety of cellu lar and immunologic markers. By the same token, these contributions marked the birth of radiation Stem Cell chimeras