Experimental hematology today, 1988 : selected papers from the 17th annual meeting of the International Society for Experimental Hematology, August 21-25, 1988, Houston, Texas, USA

**Experimental Hematology Today - 1988** presents the latest results of research reflecting the diverse interests of basic and clinical hematologists. The major areas explored are hematopoietic regulation by cytokines; hematopoietic cellular growth regulation, with emphasis on the interaction of stromal with hematopoietic stem and progenitor cells; granulopoietic regulators; gene transfers into hematopoietic progenitor cells; leukemogenesis; and bone marrow transplantation. All chapters report on research or clinical findings of the past year. Front Matter....Pages i-xv Front Matter....Pages 1-1 Interleukin 1 in Hematopoiesis....Pages 3-5 Regulation of Human B Cell Growth....Pages 6-9 Mouse Bone Marrow Cells Which Require Multiple Growth Factors for Proliferation: Examination of the Effects of Interleukin 1, Serum Factors and Inhibitor(s)....Pages 10-16 Role of NK Cells in Tumor Cell Growth and Eradication....Pages 17-21 Front Matter....Pages 23-23 A Quantitative Assay for Stroma Dependent Hemopoiesis....Pages 25-30 Matrix Glycoproteins May Regulate the Local Concentrations of Different Hemopoietic Growth Factors....Pages 31-35 Binding of Growth Factors to Heparan Sulphate: Implications for the Regulation of Hemopoiesis by Bone Marrow Stromal Cells....Pages 36-43 Front Matter....Pages 45-45 Aberrant Expression of GM-CSF in Transgenic Mice....Pages 47-53 Granulocyte Colony-Stimulating Factor....Pages 54-61 Regulation of Granulocyte-Macrophage Colony-Stimulating Factor in Murine Lymphocytes....Pages 62-67 Front Matter....Pages 69-69 Gene Transfer by Electroporation....Pages 71-74 Improved Retroviral Transfer of Genes into Canine Hematopoietic Progenitor Cells....Pages 75-80 The Use of Retroviral Vectors in Human Disorders....Pages 81-91 Towards Gene Therapy for Adenosine Deaminase Deficiency....Pages 92-98 Abnormal Gene Expression as an Early Indicator of Relapse in Acute Myelogenous Leukemia (AML)....Pages 99-101 Gene Transfer in Canine and Feline Hematopoietic Progenitor Cells with Retroviral Vectors....Pages 102-108 Introduction of the Erythropoietin Gene to a Factor-Dependent Murine Myeloid Cell Line....Pages 109-116 Front Matter....Pages 117-117 Transforming Growth Factor β: A Negative Regulator of Normal and Leukemic Hematopoietic Progenitor Cell Growth....Pages 119-124 The Regulation of Blast Stem Cell Self-Renewal in Myeloblastic Leukemia....Pages 125-131 Role of Hemopoietic Growth Factors inn the Proliferation of Acute Myeloid Leukemia....Pages 132-139 Front Matter....Pages 117-117 Alterations in Dependence on Lipoxygenase Metabolism in Myeloid Leukemia....Pages 140-146 How to Prevent a Leukemia Relapse after Bone Marrow Transplantation in Acute Leukemia: Preclinical and Clinical Model Studies....Pages 147-151 Front Matter....Pages 153-153 Allogeneic Marrow Transplantation....Pages 155-161 Autologous Bone Marrow Transplantation for Acute Leukemia in Remission: Fifth European Survey. Results of 1021 Cases....Pages 162-170 Modern Trends in Autologous Bone Marrow Transplantation....Pages 171-174 High Dose Therapy and Autologous Bone Marrow Transplantation in Non Hodgkin’s Lymphoma and Neuroblastoma....Pages 175-178 The Role of Hematopoietic Growth Factors in Nuclear and Radiation Accidents....Pages 179-182