Experimental and Clinical Hepatology: "Proceedings of the 5th Workshop on Experimental and Clinical Hepatology held at Hannover, 23-24 November 1984"

This is the fifth symposium on Experimental and Clinical Hepatology to be convened by the organisers, and, in common with the previous four, reflects the importance placed upon continuing discussion by clinical investigators as well as basic physiological and pharmacological researchers. Previous meetings which were held at the Surgical Department of the Philipps University in Marburg were dedicated to problems of direct clinical application, such as haemodynamics of portal hypertension, surgical approach to hepatic tumours, liver regeneration and temporary hepatic support. Clinical investigation was a subject which frequently came under discussion and some of these investigations have since lead to direct improvements in clinical therapy and many patients have benefited as a result. This time, the convocation was called to the Medizinische Hochschule Hannover where remarkable advances in clinical liver trans­ plantation have been the most striking event in clinical hepatology. The concensus of the meeting was that while significant clinical progress has been made, a variety of basic problems remained unsolved which will require further investigation. Special attention has, therefore, been given to topics such as acute liver damage, particu­ larly within the transplanted liver, to chronic active hepatitis and its spontaneous prognosis, to isolated hepatocytes and their effect on functional support of the liver, to mechanisms of liver circulation which may be altered completely within the transplant and to liver perfusion which is still considered unsatisfactory for subsequent transplantation. Front Matter....Pages i-xii Front Matter....Pages 1-1 Changes of the Energy — Metabolism in Liver Tissue After Experimental Common Bile Duct Obstruction....Pages 3-7 Enzymatic Detoxification of Endogenous Toxins In Vitro and In Vivo ....Pages 8-14 On the Position of the Determination of Bile Acids in Serum (Fasting = FBA and After a Standardized Test Meal = PPBA) in the Laboratory Diagnosis of Liver Diseases....Pages 15-22 On the Recognition of Hepatotoxic Side Effects of Cyclosporin A (CyA) After Liver Transplantation (LTX)....Pages 23-30 Plasma Renin Activity and Renal Function in Liver Cirrhosis Before and After Liver Transplantation....Pages 31-35 The Role of TC-99m-IDA-Scintiscanning in Neonatal Jaundice and After Surgical Treatment of Biliary Atresia....Pages 36-42 Front Matter....Pages 43-43 Hepatitis B versus Dioxin (TCDD) in the Pathogenesis of Excess Primary Liver Cell Carcinoma in Viet Nam....Pages 45-52 Assessment of Infectivity in Hepatitis B Virus Infected Individuals by Detection of HBV and Core Antigen in Serum....Pages 53-59 Decreased Detoxification Capacity of the Liver in Chronic Active Hepatitis (Observations in 224 patients)....Pages 60-65 Prognosis of Chronic Active Hepatitis: 10 years Follow-up Study in 144 Patients....Pages 66-72 Prognosis of Patients with Liver Cirrhosis and History of Variceal Bleeding after Spleno-renal and Mesocaval Shunt using Two Different Selection Criteria for Shunt Operation....Pages 73-79 On the Prognosis of Liver Cirrhosis....Pages 80-88 Front Matter....Pages 89-89 Effect of Nitroglycerin on Portal Hypertension....Pages 91-98 The Effect of Glyceryl Trinitrate on the Intravascular Oesophageal Variceal Pressure in Patients with Cirrhosis and Portal Hypertension....Pages 99-106 Is the Beta Blocking Agent Metipranolol able to Reduce the Frequency of Recurrences After Endoscopic Sclerosis because of Bleeding Esophageal Varices?....Pages 107-112 Portal Drainage for Small-bowel Grafts: A Requirement for Successful Small-bowel Transplantation?....Pages 113-123 The Effect of Portacaval Shunt on the 14 CO 2 -Exhalation from (Methyl- 14 C)-Labelled Drugs....Pages 124-130 Portal Hypertension and Hemorrhage from Esophago-gastric Varices — A Contraindication for Pregnancy?....Pages 131-135 Front Matter....Pages 137-137 Complementation of Enzyme Deficient Mutant Rats by Auxiliary Transplantation of Intact Hepatocytes: Continuous Monitoring of Hepatocyte Integrety by Scintigraphy....Pages 139-146 Transfer of Hepatocytes and Cyclosporin A Therapy — Induction of Specific Tolerance?....Pages 147-152 Front Matter....Pages 137-137 Functional Assessment of Hepatocytes after Syngeneic Transplantation into Rat Spleen....Pages 153-156 The Immunogenicity of Isolated Liver Cells: Comparison of Complete Liver Cell Suspensions (LCS) versus Liver Parenchymal Cell Suspensions (LPS) in Two Different Allogeneic Inbred Rat Strain Combinations....Pages 157-167 Membrane Expression of Autoantigens on Mechanically and Enzymatically Isolated Hepatocytes....Pages 168-178 Inhibition of Collagen Biosynthesis in Cultured Mesenchymal Cells of Human Liver by Malotilate: Treatment of Patients with Chronic Active Liver Diseases — First Results....Pages 179-183 Lack of Hormonal Response in Liver Cells from Rats with Extrahepatic Cholestasis....Pages 184-188 Regulation of the Glucose/Glucose-6-Phosphate Cycle in Cultured Hepatocytes by Insulin and Glucagon....Pages 189-194 Primary Cultures of Rat Hepatocytes as a Model for the Study of Metabolite Dependent Induction of Liponeogenic Enzymes....Pages 195-201 Increase in the Anti-infectious Capacities of Kupffer Cells by In Vitro Treatment with Endotoxin....Pages 202-208 The Role of Kupffer Cells, Endothelial Cells, and Hepatocytes in Uridine Catabolism of Rat Liver....Pages 209-212 Front Matter....Pages 213-213 Perfusion of the Isolated Rat Liver - Technique and Application in Pharmacology....Pages 215-220 Drug-derived 14 CO 2 Formation — A Method to Determine the Metabolic Capacity of the Isolated Perfused Rat Liver....Pages 221-227 Isolated Liver Perfusion in the Rat - In Vivo Model....Pages 228-233 Inhibition of Urea and Glutamine Release and of Ammonia Uptake in the Perfused Rat Liver by Stimulation of Sympathetic Hepatic Nerves....Pages 234-241 Zonation of Carbohydrate Metabolizing Enzymes in Liver of Diabetic Rats....Pages 242-247 Inhibition of Glucagon-stimulated Glucose Release in the Perfused Rat Liver by Stimulation of the Parasympathetic Hepatic Nerves....Pages 248-253 Inhibition of Ketogenesis by Stimulation of the Hepatic Sympathetic Nerves in the Perfused Rat Liver....Pages 254-259 Extracorporeal Perfusion with Baboon Liver in Acute Hepatic Failure....Pages 260-267 On Pathophysiology of Preservation Damage in Liver Transplantation....Pages 268-273 Back Matter....Pages 274-281